Diverticulosis pathophysiology: Difference between revisions
| Line 13: | Line 13: | ||
===Diverticular bleeding=== | ===Diverticular bleeding=== | ||
As a diverticulum herniates, the penetrating vessel responsible for the wall weakness at that point becomes draped over the dome of the diverticulum, separated from the [[bowel lumen]] only by [[mucosa]]<ref name="pmid1087123">{{cite journal |vauthors=Meyers MA, Alonso DR, Baer JW |title=Pathogenesis of massively bleeding colonic diverticulosis: new observations |journal=AJR Am J Roentgenol |volume=127 |issue=6 |pages=901–8 |year=1976 |pmid=1087123 |doi=10.2214/ajr.127.6.901 |url=}}</ref>Over time, the [[vasa recta]] is exposed to injury along its luminal aspect, leading to eccentric intimal thickening and thinning of the media. These changes may result in segmental weakness of the artery, predisposing to rupture into the lumen. | As a diverticulum herniates, the penetrating vessel responsible for the wall weakness at that point becomes draped over the dome of the diverticulum, separated from the [[bowel lumen]] only by [[mucosa]]<ref name="pmid1087123">{{cite journal |vauthors=Meyers MA, Alonso DR, Baer JW |title=Pathogenesis of massively bleeding colonic diverticulosis: new observations |journal=AJR Am J Roentgenol |volume=127 |issue=6 |pages=901–8 |year=1976 |pmid=1087123 |doi=10.2214/ajr.127.6.901 |url=}}</ref>Over time, the [[vasa recta (intestines)|vasa recta]] is exposed to injury along its luminal aspect, leading to eccentric intimal thickening and thinning of the media. These changes may result in segmental weakness of the artery, predisposing to rupture into the lumen. | ||
==References== | ==References== | ||
Revision as of 15:14, 2 November 2015
|
Diverticulosis Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Diverticulosis pathophysiology On the Web |
|
American Roentgen Ray Society Images of Diverticulosis pathophysiology |
|
Risk calculators and risk factors for Diverticulosis pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Pathogenesis
Diverticula develop at well-defined points of weakness, which correspond to where the vasa recta penetrate the circular muscle layer of the colon[1]. File:2015-11-02 6-30-46.jpg
A typical colonic diverticulum is a "false" or pulsion diverticulum, in which mucosa and submucosa herniate through the muscle layer,covered only by serosa. Abnormal colonic motility is an important predisposing factor in the development diverticula. Patients with diverticulosis have exaggerated segmentation contractions in which segmental muscular contractions separate the lumen into chambers. It is hypothesized that the increase in intraluminal pressure predisposes to herniation of mucosa and submucosa.
Diverticular bleeding
As a diverticulum herniates, the penetrating vessel responsible for the wall weakness at that point becomes draped over the dome of the diverticulum, separated from the bowel lumen only by mucosa[1]Over time, the vasa recta is exposed to injury along its luminal aspect, leading to eccentric intimal thickening and thinning of the media. These changes may result in segmental weakness of the artery, predisposing to rupture into the lumen.