Disseminated intravascular coagulation natural history, complications and prognosis: Difference between revisions
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{{DIC}} | {{DIC}} | ||
{{CMG}} | {{CMG}} {{AE}} {{OK}} | ||
==Overview== | ==Overview== | ||
If left untreated, 40-80% patients with [[DIC]] may progress to develop organ dysfunction. Common complications of [[DIC]] include [[renal failure]], [[hepatic dysfunction]], [[acute lung injury]], neurologic dysfunction and [[adrenal failure]]. Low levels of [[antithrombin]] at the onset if [[shock]] may predict an unfavorable prognosis. | |||
==Natural History, Complications, and Prognosis== | |||
==Natural History== | ===Natural History=== | ||
*If left untreated, 40-80% patients with [[DIC]] may progress to develop organ dysfunction | |||
==Complications== | ===Complications=== | ||
Common complications of [[DIC]] include: | |||
*[[Renal failure]] | |||
*[[Hepatic dysfunction]] | |||
*[[Acute lung injury]] | |||
*Neurologic dysfunction | |||
*[[Adrenal failure]] | |||
==Prognosis== | ===Prognosis=== | ||
* Low levels of [[antithrombin]] at the onset if [[shock]] may predict an unfavorable [[prognosis]]. <ref name="pmid8790176">{{cite journal |vauthors=Hulka F, Mullins RJ, Frank EH |title=Blunt brain injury activates the coagulation process |journal=Arch Surg |volume=131 |issue=9 |pages=923–7; discussion 927–8 |date=September 1996 |pmid=8790176 |doi= |url=}}</ref> | |||
* [[Prognosis]] depends upon the cause of [[DIC]]. <ref name="pmid15317912">{{cite journal |vauthors=Fourrier F, Chopin C, Goudemand J, Hendrycx S, Caron C, Rime A, Marey A, Lestavel P |title=Septic shock, multiple organ failure, and disseminated intravascular coagulation. Compared patterns of antithrombin III, protein C, and protein S deficiencies |journal=Chest |volume=101 |issue=3 |pages=816–23 |date=March 1992 |pmid=1531791 |doi= |url=}}</ref> | |||
*The [[prognosis]] varies with the cause<ref name="pmid9923809">{{cite journal |vauthors=Gando S, Nanzaki S, Kemmotsu O |title=Disseminated intravascular coagulation and sustained systemic inflammatory response syndrome predict organ dysfunctions after trauma: application of clinical decision analysis |journal=Ann. Surg. |volume=229 |issue=1 |pages=121–7 |date=January 1999 |pmid=9923809 |pmc=1191617 |doi= |url=}}</ref><ref name="pmid580488">{{cite journal |vauthors=Siegal T, Seligsohn U, Aghai E, Modan M |title=Clinical and laboratory aspects of disseminated intravascular coagulation (DIC): a study of 118 cases |journal=Thromb. Haemost. |volume=39 |issue=1 |pages=122–34 |date=February 1978 |pmid=580488 |doi= |url=}}</ref> | |||
==References== | ==References== | ||
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[[Category:Hematology]] | [[Category:Hematology]] | ||
[[Category:Cardiology]] | [[Category:Cardiology]] | ||
{{WS}} | {{WS}} | ||
{{WH}} | {{WH}} |
Latest revision as of 14:44, 30 August 2018
Disseminated intravascular coagulation Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Omer Kamal, M.D.[2]
Overview
If left untreated, 40-80% patients with DIC may progress to develop organ dysfunction. Common complications of DIC include renal failure, hepatic dysfunction, acute lung injury, neurologic dysfunction and adrenal failure. Low levels of antithrombin at the onset if shock may predict an unfavorable prognosis.
Natural History, Complications, and Prognosis
Natural History
- If left untreated, 40-80% patients with DIC may progress to develop organ dysfunction
Complications
Common complications of DIC include:
- Renal failure
- Hepatic dysfunction
- Acute lung injury
- Neurologic dysfunction
- Adrenal failure
Prognosis
- Low levels of antithrombin at the onset if shock may predict an unfavorable prognosis. [1]
- Prognosis depends upon the cause of DIC. [2]
- The prognosis varies with the cause[3][4]
References
- ↑ Hulka F, Mullins RJ, Frank EH (September 1996). "Blunt brain injury activates the coagulation process". Arch Surg. 131 (9): 923–7, discussion 927–8. PMID 8790176.
- ↑ Fourrier F, Chopin C, Goudemand J, Hendrycx S, Caron C, Rime A, Marey A, Lestavel P (March 1992). "Septic shock, multiple organ failure, and disseminated intravascular coagulation. Compared patterns of antithrombin III, protein C, and protein S deficiencies". Chest. 101 (3): 816–23. PMID 1531791.
- ↑ Gando S, Nanzaki S, Kemmotsu O (January 1999). "Disseminated intravascular coagulation and sustained systemic inflammatory response syndrome predict organ dysfunctions after trauma: application of clinical decision analysis". Ann. Surg. 229 (1): 121–7. PMC 1191617. PMID 9923809.
- ↑ Siegal T, Seligsohn U, Aghai E, Modan M (February 1978). "Clinical and laboratory aspects of disseminated intravascular coagulation (DIC): a study of 118 cases". Thromb. Haemost. 39 (1): 122–34. PMID 580488.