Disseminated intravascular coagulation diagnostic study of choice

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]; Associate Editor(s)-in-Chief: Omer Kamal, M.D.[3]

Overview

There is no single diagnostic study of choice for DIC, though DIC may be diagnosed based on the diagnostic criteria established by Japanese Society on Thrombosis and Hemostasis.

Diagnostic Study of Choice

Study of choice

There is no single diagnostic study of choice for the diagnosis of disseminated intravascular coagulation. DIC is a clinical as well as a laboratory diagnosis.

Name of Diagnostic Criteria

There is no single diagnostic study of choice for DIC, though DIC may be diagnosed based on the diagnostic criteria established by Japanese Society on Thrombosis and Hemostasis.

JSTH’s DIC diagnostic criteria

	Classification of type	Basic		Hematopoietic disorder		Infectious
Global coagulation tests	Platelet count (×103/μl)	>120	0 p			>120	0 p
		80 < − ≤ 120	1 p			80 < − ≤ 120	1 p
		50 < − ≤ 80	2 p			50 < − ≤ 80	2 p
		≤50	3 p			≤50	3 p
		≥30% decrease w/in 24 h (*1)	+1 p			≥30% decrease w/in 24 h (*1)	+1 p
	FDP (μg/ml)	<10	0 p	<10	0 p	<10	0 p
		10 ≤ − < 20	1 p	10 ≤ − < 20	1 p	10 ≤ − < 20	1 p
		20 ≤ − < 40	2 p	20 ≤ − < 40	2 p	20 ≤ − < 40	2 p
		≥40	3 p	≥40	3 p	≥40	3 p
	Fibrinogen (mg/dl)	>150	0 p	>150	0 p
		100 < − ≤ 150	1 p	100 < − ≤ 150	1 p
		≤100	2 p	≤100	2 p
	Prothrombin time ratio	<1.25	0 p	<1.25	0 p	<1.25	0 p
		1.25 ≤ − < 1.67	1 p	1.25 ≤ − < 1.67	1 p	1.25 ≤ − < 1.67	1 p
		≥1.67	2 p	≥1.67	2 p	≥1.67	2 p
Hemostatic molecular markers	Antithrombin (%)	>70	0 p	>70	0 p	>70	0 p
		≤70	1 p	≤70	1 p	≤70	1 p
	TAT, SF or F1+2	<2-fold of normal upper limit	0 p	<2-fold of normal upper limit	0 p	<2-fold of normal upper limit	0 p
		≥2-fold of normal upper limit	1 p	≥2-fold of normal upper limit	1 p	≥2-fold of normal upper limit	1 p
Liver failure (*2)		No	0 p	No	0 p	No	0 p
		Yes	−3 p	Yes	−3 p	Yes	−3 p
DIC diagnosis		≥6 p		≥4 p		≥5 p