Differentiating Ewing's sarcoma from other diseases

Ewing's sarcoma Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Assistant Editor(s)-In-Chief: Michael Maddaleni, B.S.

Differentiating Ewing's Sarcoma from other Diseases

• Osteosarcoma

• ALP is not elevated in Ewing sarcoma.

• Ewing's sarcoma tends to arise from the diaphysis whereas in osteosarcoma it tends to arise from the metaphysis.

• Osteomyelitis
• Hematological malignancy
• Eosinophilic granuloma
• Malignant fibrous histiocytoma that erode into adjacent bone may also have a similar appearance.