Differentiating Diabetes mellitus type 1 from other diseases: Difference between revisions
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[[Image:Home_logo1.png|right|250px|link=https://www.wikidoc.org/index.php/Diabetes_mellitus_type_1]] | |||
{{Diabetes mellitus}} | {{Diabetes mellitus}} | ||
{{CMG}} | {{CMG}} | ||
==Overview== | ==Overview== | ||
[[Type 1 | [[Type 1 diabetes mellitus]] must be differentiated from [[type 2 diabetes mellitus]], [[maturity onset diabetes of the young]] ([[Maturity onset diabetes of the young|MODY-DM]]), [[psychogenic polydipsia]], [[diabetes insipidus]], transient [[hyperglycemia]], [[steroid]] [[therapy]], [[Renal tubular acidosis|renal tubular acidosis type-1]], [[glucagonoma]], [[cushing's syndrome]], and [[hypothyroidism]]. | ||
== Differentiating Diabetes mellitus type 1 from other Diseases== | == Differentiating Diabetes mellitus type 1 from other Diseases== | ||
Differential diagnosis of type 1 | * [[Differential diagnosis]] of [[type 1 diabetes mellitus]], include: <ref name="pmid17727381">{{cite journal| author=Barrett TG| title=Differential diagnosis of type 1 diabetes: which genetic syndromes need to be considered? | journal=Pediatr Diabetes | year= 2007 | volume= 8 Suppl 6 | issue= | pages= 15-23 | pmid=17727381 | doi=10.1111/j.1399-5448.2007.00278.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17727381 }}</ref><ref>Type 1 Diabetes mellitus "Dennis Kasper, Anthony Fauci, Stephen Hauser, Dan Longo, J. Larry Jameson, Joseph Loscalzo"Harrison's Principles of Internal Medicine, 19e Accessed on December 27th,2016</ref><ref>{{Cite web|url=http://www.namrata.co/diabetes-mellitus-differential-diagnosis-and-management/|title=namrata|last=|first=|date=|website=|publisher=|access-date=}}</ref> | ||
* [[Type 2 diabetes mellitus|Type 2 DM]] | ** [[Type 2 diabetes mellitus|Type 2 DM]] | ||
* [[Maturity onset diabetes of the young|MODY-DM]] | ** [[Maturity onset diabetes of the young|MODY-DM]] | ||
* [[Psychogenic polydipsia]] | ** [[Psychogenic polydipsia]] | ||
* [[Diabetes insipidus]] | ** [[Diabetes insipidus]] | ||
* Transient hyperglycemia | ** Transient [[hyperglycemia]] | ||
* Steroid therapy | ** [[Steroid]] [[therapy]] | ||
* [[Renal tubular acidosis|Renal tubular acidosis type-1]] | ** [[Renal tubular acidosis|Renal tubular acidosis type-1]] | ||
* [[Glucagonoma]] | ** [[Glucagonoma]] | ||
* [[Cushing's syndrome]] | ** [[Cushing's syndrome]] | ||
* [[Hypothyroidism]] | ** [[Hypothyroidism]] | ||
* [[Wolfram syndrome]] | ** [[Wolfram syndrome]] | ||
* [[Alstrom syndrome]] | ** [[Alstrom syndrome]] | ||
{| style="border: 0px; font-size: 90%; margin: 3px;" align=center | {| style="border: 0px; font-size: 90%; margin: 3px;" align=center | ||
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!align="center" style="background:#4479BA; color: #FFFFFF;"|Serum glucagon | !align="center" style="background:#4479BA; color: #FFFFFF;"|Serum glucagon | ||
|- | |- | ||
|style="padding: 5px 5px; background: #DCDCDC;" align="center" |Type 1 Diabetes mellitus | |style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Diabetes mellitus type 1|Type 1 Diabetes mellitus]] | ||
|style="padding: 5px 5px; background: #F5F5F5;" align="center" |✔ | |style="padding: 5px 5px; background: #F5F5F5;" align="center" |✔ | ||
|style="padding: 5px 5px; background: #F5F5F5;" align="center" |✔ | |style="padding: 5px 5px; background: #F5F5F5;" align="center" |✔ | ||
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|style="padding: 5px 5px; background: #F5F5F5;" align="center" |'''↓''' | |style="padding: 5px 5px; background: #F5F5F5;" align="center" |'''↓''' | ||
|style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal | |style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal | ||
|style="padding: 5px 5px; background: #F5F5F5;" align="center" | | |style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[autoantibody|Autoantibodies]] present ([[GAD65|Anti GAD-65]] and anti [[insulin]] [[autoantibody|autoantibodies]]) | ||
|- | |- | ||
|style="padding: 5px 5px; background: #DCDCDC;" align="center" |Type 2 Diabetes mellitus | |style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Diabetes mellitus type 2|Type 2 Diabetes mellitus]] | ||
|style="padding: 5px 5px; background: #F5F5F5;" align="center" |✔ | |style="padding: 5px 5px; background: #F5F5F5;" align="center" |✔ | ||
|style="padding: 5px 5px; background: #F5F5F5;" align="center" |✔ | |style="padding: 5px 5px; background: #F5F5F5;" align="center" |✔ | ||
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|style="padding: 5px 5px; background: #F5F5F5;" align="center" |In hospitalized patients especially in [[ICU]] and [[CCU]] | |style="padding: 5px 5px; background: #F5F5F5;" align="center" |In hospitalized patients especially in [[ICU]] and [[CCU]] | ||
|- | |- | ||
|style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Steroid]] therapy | |style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Steroid]] [[therapy]] | ||
|style="padding: 5px 5px; background: #F5F5F5;" align="center" |✔ | |style="padding: 5px 5px; background: #F5F5F5;" align="center" |✔ | ||
|style="padding: 5px 5px; background: #F5F5F5;" align="center" | - | |style="padding: 5px 5px; background: #F5F5F5;" align="center" | - | ||
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==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
{{WH}} | |||
{{WS}} | |||
[[Category:Needs content]] | [[Category:Needs content]] | ||
[[Category:Endocrinology]] | [[Category:Endocrinology]] | ||
[[Category:Emergency medicine]] | [[Category:Emergency medicine]] | ||
Latest revision as of 16:51, 1 September 2020
Diabetes mellitus Main page |
Patient Information |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Type 1 diabetes mellitus must be differentiated from type 2 diabetes mellitus, maturity onset diabetes of the young (MODY-DM), psychogenic polydipsia, diabetes insipidus, transient hyperglycemia, steroid therapy, renal tubular acidosis type-1, glucagonoma, cushing's syndrome, and hypothyroidism.
Differentiating Diabetes mellitus type 1 from other Diseases
- Differential diagnosis of type 1 diabetes mellitus, include: [1][2][3]
Disease | History and symptoms | Laboratory findings | Additional findings | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Polyuria | Polydipsia | Polyphagia | Weight loss | Weight gain | Serum glucose | Urinary Glucose | Urine PH | Serum Sodium | Urinary Glucose | 24 hrs cortisol level | C-peptide level | Serum glucagon | ||
Type 1 Diabetes mellitus | ✔ | ✔ | ✔ | ✔ | - | ↑ | ↑ | Normal | Normal | N/↑ | Normal | ↓ | Normal | Autoantibodies present (Anti GAD-65 and anti insulin autoantibodies) |
Type 2 Diabetes mellitus | ✔ | ✔ | ✔ | ✔ | - | ↑ | ↑ | Normal | Normal | ↑ | Normal | Normal | ↑ | Acanthosis nigricans |
MODY | ✔ | ✔ | ✔ | - | ✔ | ↑ | ↑ | Normal | Normal | ↑ | Normal | Normal | N | - |
Psychogenic polydipsia | ✔ | ✔ | - | - | - | Normal | Normal | Normal | ↓ | Normal | Normal | Normal | Normal | - |
Diabetes insipidus | ✔ | ✔ | - | - | - | Normal | Normal | Normal | ↑ | Normal | Normal | Normal | Normal | - |
Transient hyperglycemia | - | - | - | - | - | ↑ | ↑ | Normal | Normal | ↑ | Normal | Normal | N/↑ | In hospitalized patients especially in ICU and CCU |
Steroid therapy | ✔ | - | - | - | ✔ | ↑ | ↑ | Normal | Normal | ↑ | ↑ | N/↑ | N/↑ | Acanthosis nigricans, |
RTA 1 | - | - | - | ✔ | - | Normal | Normal | ↑ | Normal | ↑ | Normal | Normal | Normal | Hypokalemia, nephrolithiasis |
Glucagonoma | - | - | - | - | - | ↑ | Normal | Normal | Normal | - | Normal | Normal | ↑ | Necrolytic migratory erythema |
Cushing syndrome | - | - | - | - | ✔ | ↑ | - | Normal | ↓ | N/↑ | ↑ | Normal | Normal | Moon face, obesity, buffalo hump, easy bruisibility |
References
- ↑ Barrett TG (2007). "Differential diagnosis of type 1 diabetes: which genetic syndromes need to be considered?". Pediatr Diabetes. 8 Suppl 6: 15–23. doi:10.1111/j.1399-5448.2007.00278.x. PMID 17727381.
- ↑ Type 1 Diabetes mellitus "Dennis Kasper, Anthony Fauci, Stephen Hauser, Dan Longo, J. Larry Jameson, Joseph Loscalzo"Harrison's Principles of Internal Medicine, 19e Accessed on December 27th,2016
- ↑ "namrata".