Demeclocycline hydrochloride
| Demeclocycline hydrochloride |
|---|
| DEMECLOCYCLINE HYDROCHLORIDE® FDA Package Insert |
| Description |
| Clinical Pharmacology |
| Microbiology |
| Indications and Usage |
| Contraindications |
| Warnings and Precautions |
| Adverse Reactions |
| Drug Interactions |
| Overdosage |
| Dosage and Administration |
| How Supplied |
| Labels and Packages |
For patient information, click here.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Demeclocycline is a tetracycline antibiotic derived from a strain of Streptomyces aureofaciens.[1]
It is officially indicated for the treatment of various types of bacterial infections.[2] It is used as an antibiotic in the treatment of Lyme disease, acne, and bronchitis.[citation needed] Resistance, though, is gradually becoming more common, and demeclocycline is now rarely used for infections.
Category
US Brand Names
DEMECLOCYCLINE HYDROCHLORIDE®
FDA Package Insert
Description | Clinical Pharmacology | Microbiology | Indications and Usage | Contraindications | Warnings and Precautions | Adverse Reactions | Drug Interactions | Overdosage | Clinical Studies | Dosage and Administration | How Supplied | Labels and Packages
Mechanism of Action
As with related tetracycline antibiotics, demeclocycline acts by binding to the 30S and 50S ribosomal subunits, which impairs protein synthesis by bacteria. It is bacteriostatic (it impairs bacterial growth, but does not kill bacteria directly).
It is not completely understood why demeclocycline impairs the action of antidiuretic hormone, but is thought to block the binding of the hormone from its receptor.[3]
References
- ↑ Template:DorlandsDict
- ↑ "DailyMed: About DailyMed". Retrieved 2008-12-20.
- ↑ De Troyer A, Demanet JC (1975). "Correction of antidiuresis by demeclocycline". N Engl J Med. 293 (18): 915–8. doi:10.1056/NEJM197510302931809. PMID 170519.