DGKZ

Diacylglycerol kinase, zeta 104kDa
Identifiers
Symbols	DGKZ ; DAGK5; DAGK6; DGK-ZETA; hDGKzeta
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37831
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Diacylglycerol kinase, zeta 104kDa, also known as DGKZ, is a human gene.

The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Bunting M, Tang W, Zimmerman GA; et al. (1996). "Molecular cloning and characterization of a novel human diacylglycerol kinase zeta". J. Biol. Chem. 271 (17): 10230–6. PMID 8626588.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ding L, Bunting M, Topham MK; et al. (1997). "Alternative splicing of the human diacylglycerol kinase zeta gene in muscle". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5519–24. PMID 9159104.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Topham MK, Bunting M, Zimmerman GA; et al. (1998). "Protein kinase C regulates the nuclear localization of diacylglycerol kinase-zeta". Nature. 394 (6694): 697–700. doi:10.1038/29337. PMID 9716136.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu Z, Chang GQ, Leibowitz SF (2001). "Diacylglycerol kinase zeta in hypothalamus interacts with long form leptin receptor. Relation to dietary fat and body weight regulation". J. Biol. Chem. 276 (8): 5900–7. doi:10.1074/jbc.M007311200. PMID 11078732.CS1 maint: Multiple names: authors list (link)
• Topham MK, Prescott SM (2001). "Diacylglycerol kinase zeta regulates Ras activation by a novel mechanism". J. Cell Biol. 152 (6): 1135–43. PMID 11257115.
• Hogan A, Shepherd L, Chabot J; et al. (2001). "Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions". J. Biol. Chem. 276 (28): 26526–33. doi:10.1074/jbc.M104156200. PMID 11352924.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Santos T, Carrasco S, Jones DR; et al. (2002). "Dynamics of diacylglycerol kinase zeta translocation in living T-cells. Study of the structural domain requirements for translocation and activity". J. Biol. Chem. 277 (33): 30300–9. doi:10.1074/jbc.M200999200. PMID 12015310.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhong XP, Hainey EA, Olenchock BA; et al. (2002). "Regulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase zeta". J. Biol. Chem. 277 (34): 31089–98. doi:10.1074/jbc.M203818200. PMID 12070163.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhong XP, Hainey EA, Olenchock BA; et al. (2003). "Enhanced T cell responses due to diacylglycerol kinase zeta deficiency". Nat. Immunol. 4 (9): 882–90. doi:10.1038/ni958. PMID 12883552.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Luo B, Prescott SM, Topham MK (2003). "Protein kinase C alpha phosphorylates and negatively regulates diacylglycerol kinase zeta". J. Biol. Chem. 278 (41): 39542–7. doi:10.1074/jbc.M307153200. PMID 12890670.CS1 maint: Multiple names: authors list (link)
• Abramovici H, Hogan AB, Obagi C; et al. (2004). "Diacylglycerol kinase-zeta localization in skeletal muscle is regulated by phosphorylation and interaction with syntrophins". Mol. Biol. Cell. 14 (11): 4499–511. doi:10.1091/mbc.E03-03-0190. PMID 14551255.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Davidson L, Pawson AJ, López de Maturana R; et al. (2004). "Gonadotropin-releasing hormone-induced activation of diacylglycerol kinase-zeta and its association with active c-src". J. Biol. Chem. 279 (12): 11906–16. doi:10.1074/jbc.M310784200. PMID 14707140.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Luo B, Prescott SM, Topham MK (2005). "Diacylglycerol kinase zeta regulates phosphatidylinositol 4-phosphate 5-kinase Ialpha by a novel mechanism". Cell. Signal. 16 (8): 891–7. doi:10.1016/j.cellsig.2004.01.010. PMID 15157668.CS1 maint: Multiple names: authors list (link)
• Avila-Flores A, Santos T, Rincón E, Mérida I (2005). "Modulation of the mammalian target of rapamycin pathway by diacylglycerol kinase-produced phosphatidic acid". J. Biol. Chem. 280 (11): 10091–9. doi:10.1074/jbc.M412296200. PMID 15632115.CS1 maint: Multiple names: authors list (link)
• Los AP, Vinke FP, de Widt J; et al. (2006). "The retinoblastoma family proteins bind to and activate diacylglycerol kinase zeta". J. Biol. Chem. 281 (2): 858–66. doi:10.1074/jbc.M502693200. PMID 16286473.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)