DDX1

DEAD (Asp-Glu-Ala-Asp) box polypeptide 1
Identifiers
Symbols	DDX1 ; DBP-RB; UKVH5d
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3627
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

DEAD (Asp-Glu-Ala-Asp) box polypeptide 1, also known as DDX1, is a human gene.

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein of unknown function. It shows high transcription levels in 2 retinoblastoma cell lines and in tissues of neuroectodermal origin.

Further reading

• Schmid SR, Linder P (1992). "D-E-A-D protein family of putative RNA helicases". Mol. Microbiol. 6 (3): 283–91. PMID 1552844.
• Li L, Li HS, Pauza CD; et al. (2006). "Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions". Cell Res. 15 (11–12): 923–34. doi:10.1038/sj.cr.7290370. PMID 16354571.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Godbout R, Squire J (1993). "Amplification of a DEAD box protein gene in retinoblastoma cell lines". Proc. Natl. Acad. Sci. U.S.A. 90 (16): 7578–82. PMID 7689221.
• Kitajima Y, Yatsuki H, Zhang R; et al. (1994). "A novel human homologue of a dead-box RNA helicase family". Biochem. Biophys. Res. Commun. 199 (2): 748–54. PMID 8135819.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Akiyama K, Akao Y, Yokoyama M; et al. (1999). "Expression of two dead box genes (DDX1 and DDX6) is independent of that of MYCN in human neuroblastoma cell lines". Biochem. Mol. Biol. Int. 47 (4): 563–8. PMID 10319407.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Golembowski S, Gellrich S, von Zimmermann M; et al. (2000). "Clonal evolution in a primary cutaneous follicle center B cell lymphoma revealed by single cell analysis in sequential biopsies". Immunobiology. 201 (5): 631–44. PMID 10834319.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bléoo S, Sun X, Hendzel MJ; et al. (2002). "Association of human DEAD box protein DDX1 with a cleavage stimulation factor involved in 3'-end processing of pre-MRNA". Mol. Biol. Cell. 12 (10): 3046–59. PMID 11598190.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Andersen JS, Lyon CE, Fox AH; et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. PMID 11790298.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen HC, Lin WC, Tsay YG; et al. (2002). "An RNA helicase, DDX1, interacting with poly(A) RNA and heterogeneous nuclear ribonucleoprotein K.". J. Biol. Chem. 277 (43): 40403–9. doi:10.1074/jbc.M206981200. PMID 12183465.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fang J, Kubota S, Yang B; et al. (2005). "A DEAD box protein facilitates HIV-1 replication as a cellular co-factor of Rev". Virology. 330 (2): 471–80. doi:10.1016/j.virol.2004.09.039. PMID 15567440.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Krishnan V, Zeichner SL (2006). "Alterations in the expression of DEAD-box and other RNA binding proteins during HIV-1 replication". Retrovirology. 1: 42. doi:10.1186/1742-4690-1-42. PMID 15588285.
• Andersen JS, Lam YW, Leung AK; et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fang J, Acheampong E, Dave R; et al. (2005). "The RNA helicase DDX1 is involved in restricted HIV-1 Rev function in human astrocytes". Virology. 336 (2): 299–307. doi:10.1016/j.virol.2005.03.017. PMID 15892970.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kaneko S, Ohira M, Nakamura Y; et al. (2007). "Relationship of DDX1 and NAG gene amplification/overexpression to the prognosis of patients with MYCN-amplified neuroblastoma". J. Cancer Res. Clin. Oncol. 133 (3): 185–92. doi:10.1007/s00432-006-0156-y. PMID 17028906.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tu LC, Yan X, Hood L, Lin B (2007). "Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells". Mol. Cell Proteomics. 6 (4): 575–88. doi:10.1074/mcp.M600249-MCP200. PMID 17220478.CS1 maint: Multiple names: authors list (link)