DAPT score
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sadaf Sharfaei M.D.[2]
Synonyms and keywords: Dual Antiplatelet Therapy score; DAPT (Dual Antiplatelet Therapy) score; DAPT score calculator; Dual Antiplatelet Therapy score calculator; DAPT (Dual Antiplatelet Therapy) score calculator
Overview
The DAPT score is a clinical prediction score assessing late ischemic and bleeding risks to inform the duration of dual antiplatelet therapy (DAPT). The score was derived from the DAPT study (ClinicalTrials.gov: NCT00977938) and initially validated in the PROTECT trial (ClinicalTrials.gov: NCT00476957).
DAPT Score
The DAPT score is a simplified clinical prediction score designed to assess the tradeoff between ischemia prevention (myocardial infarction or stent thrombosis) and bleeding increase (moderate or severe hemorrhage) associated with continued thienopyridine plus aspirin versus aspirin alone beyond one year after percutaneous coronary intervention (PCI) based on 11,648 patients enrolled in the DAPT study (derivation cohort) and 8,136 patients enrolled in the PROTECT trial (validation cohort).[1][2][3][4][5][6]
DAPT Score Calculator
Shown below is the calculator for DAPT score (check all the boxes that apply):
Interpretation
- Score <2: Higher risk of bleeding and a smaller reduction in ischemia, associated with an unfavorable benefit-to-risk ratio for prolonged DAPT
- Score ≥2: Smaller risk of bleeding and a greater reduction in ischemia, associated with a favorable benefit-to-risk ratio for prolonged DAPT
See also
References
- ↑ Yeh, Robert W.; Secemsky, Eric A.; Kereiakes, Dean J.; Normand, Sharon-Lise T.; Gershlick, Anthony H.; Cohen, David J.; Spertus, John A.; Steg, Philippe Gabriel; Cutlip, Donald E.; Rinaldi, Michael J.; Camenzind, Edoardo; Wijns, William; Apruzzese, Patricia K.; Song, Yang; Massaro, Joseph M.; Mauri, Laura (2016). "Development and Validation of a Prediction Rule for Benefit and Harm of Dual Antiplatelet Therapy Beyond 1 Year After Percutaneous Coronary Intervention". JAMA. 315 (16): 1735. doi:10.1001/jama.2016.3775. ISSN 0098-7484.
- ↑ Piccolo, Raffaele; Gargiulo, Giuseppe; Franzone, Anna; Santucci, Andrea; Ariotti, Sara; Baldo, Andrea; Tumscitz, Carlo; Moschovitis, Aris; Windecker, Stephan; Valgimigli, Marco (2017). "Use of the Dual-Antiplatelet Therapy Score to Guide Treatment Duration After Percutaneous Coronary Intervention". Annals of Internal Medicine. 167 (1): 17. doi:10.7326/M16-2389. ISSN 0003-4819.
- ↑ Kereiakes, Dean J.; Yeh, Robert W.; Massaro, Joseph M.; Cutlip, Donald E.; Steg, P. Gabriel; Wiviott, Stephen D.; Mauri, Laura (2016). "DAPT Score Utility for Risk Prediction in Patients With or Without Previous Myocardial Infarction". Journal of the American College of Cardiology. 67 (21): 2492–2502. doi:10.1016/j.jacc.2016.03.485. ISSN 0735-1097.
- ↑ Yoshikawa, Yusuke; Shiomi, Hiroki; Watanabe, Hirotoshi; Natsuaki, Masahiro; Kondo, Hirokazu; Tamura, Toshihiro; Nakagawa, Yoshihisa; Morimoto, Takeshi; Kimura, Takeshi (2018). "Validating Utility of Dual Antiplatelet Therapy Score in a Large Pooled Cohort From 3 Japanese Percutaneous Coronary Intervention Studies". Circulation. 137 (6): 551–562. doi:10.1161/CIRCULATIONAHA.117.028924. ISSN 0009-7322.
- ↑ Banerjee, Subhash; Angiolillo, Dominick J.; Boden, William E.; Murphy, Joseph G.; Khalili, Houman; Hasan, Ahmed A.; Harrington, Robert A.; Rao, Sunil V. (2017). "Use of Antiplatelet Therapy/DAPT for Post-PCI Patients Undergoing Noncardiac Surgery". Journal of the American College of Cardiology. 69 (14): 1861–1870. doi:10.1016/j.jacc.2017.02.012. ISSN 0735-1097.
- ↑ "An International Randomized Trial Comparing Four Thrombolytic Strategies for Acute Myocardial Infarction". New England Journal of Medicine. 329 (10): 673–682. 1993. doi:10.1056/NEJM199309023291001. ISSN 0028-4793.