Creutzfeldt-Jakob disease overview

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Creutzfeldt-Jakob disease is a very rare and incurable degenerative neurological disorder (brain disease) that is ultimately fatal. Among the types of transmissible spongiform encephalopathy found in humans, it is the most common.[1]

Historical Perspective

Creutzfeldt Jakob disease was first coined by Spielmeyer in 1922 to describe cases of rapidly progressive dementia reported by Creutzfeldt in 1920 and Jakob in 1921.[2]

Classification

Creutzfeldt-Jakob disease is a rare fatal neurodegenerative disorder, it can occur in sporadic, familial and iatrogenic forms. Variant forms of CJD (vCJD) have also been recognized.

Diagnosis

Laboratory Findings

The diagnosis of CJD is suspected when there are typical clinical symptoms and signs such as rapidly progressing dementia with myoclonus. Analysis of CSF for 14-3-3 protein is done to establish diagnosis.[3]

References

  1. "http://www.cdc.gov/ncidod/dvrd/cjd/". Retrieved 14 February 2014. External link in |title= (help)
  2. McKintosh, E.; Tabrizi, SJ.; Collinge, J. (2003). "Prion diseases". J Neurovirol. 9 (2): 183–93. doi:10.1080/13550280390194082. PMID 12707849. Unknown parameter |month= ignored (help)
  3. "https://www.aan.com/Guidelines/home/GetGuidelineContent/567". Retrieved 14 February 2014. External link in |title= (help)


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