Clonidine: Difference between revisions

Revision as of 19:07, 5 February 2014

Clonidine
CATAPRES^® FDA Package Insert
Indications and Usage
Dosage and Administration
Dosage Forms and Strengths
Contraindications
Warnings and Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Overdosage
Description
Clinical Pharmacology
Nonclinical Toxicology
Clinical Studies
How Supplied/Storage and Handling
Patient Counseling Information
Labels and Packages
CLONIDINE patch ^® FDA Package Insert
Indications and Usage
Dosage and Administration
Dosage Forms and Strengths
Contraindications
Warnings and Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Overdosage
Description
Clinical Pharmacology
Nonclinical Toxicology
Clinical Studies
How Supplied/Storage and Handling
Patient Counseling Information
Labels and Packages
DURACLON (clonidine hydrochloride) injection^® FDA Package Insert
Indications and Usage
Dosage and Administration
Dosage Forms and Strengths
Contraindications
Warnings and Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Overdosage
Description
Clinical Pharmacology
Nonclinical Toxicology
Clinical Studies
How Supplied/Storage and Handling
Patient Counseling Information
Labels and Packages
Clinical Trials on Clonidine
ClinicalTrials.gov

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Pratik Bahekar, MBBS [2]

For patient information about Clonidine, click here

Synonyms / Brand Names:

Overview

Not to be confused with clomifene, clonazepam (Klonopin), or clozapine.

Clonidine (trade names Catapres, Kapvay, Nexiclon and others) is a sympatholytic medication used to treat high blood pressure, ADHD, anxiety/panic disorder, and certain pain conditions. It is classified as a centrally acting α2 adrenergic agonist. An alternative hypothesis that has been proposed is that clonidine acts centrally as an imidazoline receptor agonist.

CATAPRES

CLONIDINE patch

DURACLON

Mechanism of action

Clonidine treats high blood pressure by stimulating α₂-receptors in the brain, which decreases peripheral vascular resistance, lowering blood pressure. It has specificity towards the presynaptic α₂-receptors in the vasomotor center in the brainstem. This binding decreases presynaptic calcium levels, thus inhibiting the release of norepinephrine (NE). The net effect is a decrease in sympathetic tone.

It has also been proposed that the antihypertensive effect of clonidine is due to agonism on the I₁-receptor (imidazoline receptor), which mediates the sympatho-inhibitory actions of imidazolines to lower blood pressure.

Its mechanism of action in the treatment of ADHD is to increase noradrenergic tone in the prefrontal cortex (PFC) directly by binding to postsynaptic α_2A adrenergic receptors and indirectly by increasing norepinephrine input from the locus coeruleus.

Receptor	K_i (nM)
α_1A	316.2278
α_1B	316.2278
α_1D	125.8925
α_2A	42.92
α_2B	106.31
α_2C	233.1

References

@@ Line 18: / Line 18: @@
 Centrally acting α2 adrenergic agonist.
-==FDA Package Insert==
+==CATAPRES==
+'''| [[CATAPRES indications and usage|Indications and Usage]]'''
+'''| [[CATAPRES dosage and administration|Dosage and Administration]]'''
+'''| [[CATAPRES dosage forms and strengths|Dosage Forms and Strengths]]'''
+'''| [[CATAPRES contraindications|Contraindications]]'''
+'''| [[CATAPRES warnings and precautions|Warnings and Precautions]]'''
+'''| [[CATAPRES adverse reactions|Adverse Reactions]]'''
+'''| [[CATAPRES drug interactions|Drug Interactions]]'''
+'''| [[CATAPRES use in specific populations|Use in Specific Populations]]'''
+'''| [[CATAPRES overdosage|Overdosage]]'''
+'''| [[CATAPRES description|Description]]'''
+'''| [[CATAPRES clinical pharmacology|Clinical Pharmacology]]'''
+'''| [[CATAPRES nonclinical toxicology|Nonclinical Toxicology]]'''
+'''| [[CATAPRES clinical studies|Clinical Studies]]'''
+'''| [[CATAPRES how supplied storage and handling|How Supplied/Storage and Handling]]'''
+'''| [[CATAPRES patient counseling information|Patient Counseling Information]]'''
+'''| [[CATAPRES labels and packages|Labels and Packages]]'''
+==CLONIDINE patch==
+'''| [[CLONIDINE patch indications and usage|Indications and Usage]]'''
+'''| [[CLONIDINE patch dosage and administration|Dosage and Administration]]'''
+'''| [[CLONIDINE patch dosage forms and strengths|Dosage Forms and Strengths]]'''
+'''| [[CLONIDINE patch contraindications|Contraindications]]'''
+'''| [[CLONIDINE patch warnings and precautions|Warnings and Precautions]]'''
+'''| [[CLONIDINE patch adverse reactions|Adverse Reactions]]'''
+'''| [[CLONIDINE patch drug interactions|Drug Interactions]]'''
+'''| [[CLONIDINE patch use in specific populations|Use in Specific Populations]]'''
+'''| [[CLONIDINE patch overdosage|Overdosage]]'''
+'''| [[CLONIDINE patch description|Description]]'''
+'''| [[CLONIDINE patch clinical pharmacology|Clinical Pharmacology]]'''
+'''| [[CLONIDINE patch nonclinical toxicology|Nonclinical Toxicology]]'''
+'''| [[CLONIDINE patch clinical studies|Clinical Studies]]'''
+'''| [[CLONIDINE patch how supplied storage and handling|How Supplied/Storage and Handling]]'''
+'''| [[CLONIDINE patch patient counseling information|Patient Counseling Information]]'''
+'''| [[CLONIDINE patch labels and packages|Labels and Packages]]'''
+==DURACLON==
+'''| [[DURACLON indications and usage|Indications and Usage]]'''
+'''| [[DURACLON dosage and administration|Dosage and Administration]]'''
+'''| [[DURACLON dosage forms and strengths|Dosage Forms and Strengths]]'''
+'''| [[DURACLON contraindications|Contraindications]]'''
+'''| [[DURACLON warnings and precautions|Warnings and Precautions]]'''
+'''| [[DURACLON adverse reactions|Adverse Reactions]]'''
+'''| [[DURACLON drug interactions|Drug Interactions]]'''
+'''| [[DURACLON use in specific populations|Use in Specific Populations]]'''
+'''| [[DURACLON overdosage|Overdosage]]'''
+'''| [[DURACLON description|Description]]'''
+'''| [[DURACLON clinical pharmacology|Clinical Pharmacology]]'''
+'''| [[DURACLON nonclinical toxicology|Nonclinical Toxicology]]'''
+'''| [[DURACLON clinical studies|Clinical Studies]]'''
+'''| [[DURACLON how supplied storage and handling|How Supplied/Storage and Handling]]'''
+'''| [[DURACLON patient counseling information|Patient Counseling Information]]'''
+'''| [[DURACLON labels and packages|Labels and Packages]]'''
-'''| [[Clonidine indications and usage|Indications and Usage]]'''
-'''| [[Clonidine dosage and administration|Dosage and Administration]]'''
-'''| [[Clonidine dosage forms and strengths|Dosage Forms and Strengths]]'''
-'''| [[Clonidine contraindications|Contraindications]]'''
-'''| [[Clonidine warnings and precautions|Warnings and Precautions]]'''
-'''| [[Clonidine adverse reactions|Adverse Reactions]]'''
-'''| [[Clonidine drug interactions|Drug Interactions]]'''
-'''| [[Clonidine use in specific populations|Use in Specific Populations]]'''
-'''| [[Clonidine overdosage|Overdosage]]'''
-'''| [[Clonidine description|Description]]'''
-'''| [[Clonidine clinical pharmacology|Clinical Pharmacology]]'''
-'''| [[Clonidine nonclinical toxicology|Nonclinical Toxicology]]'''
-'''| [[Clonidine clinical studies|Clinical Studies]]'''
-'''| [[Clonidine how supplied storage and handling|How Supplied/Storage and Handling]]'''
-'''| [[Clonidine patient counseling information|Patient Counseling Information]]'''
-'''| [[Clonidine labels and packages|Labels and Packages]]'''
 ==Mechanism of action==