Ciclopirox: Difference between revisions
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==Overview== | ==Overview== | ||
'''Ciclopirox olamine''' is a synthetic [[Antifungal medication|antifungal]] agent for topical [[dermatology|dermatologic]] treatment of [[Mycosis#Superficial mycoses|superficial mycoses]]. | |||
==Category== | ==Category== | ||
Antifungal | Antifungal | ||
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'''| [[Ciclopirox warnings and precautions|Warnings and Precautions]]''' | '''| [[Ciclopirox warnings and precautions|Warnings and Precautions]]''' | ||
'''| [[Ciclopirox adverse reactions|Adverse Reactions]]''' | '''| [[Ciclopirox adverse reactions|Adverse Reactions]]''' | ||
'''| [[Ciclopirox dosage and administration|Dosage and Administration]]''' | '''| [[Ciclopirox dosage and administration|Dosage and Administration]]''' | ||
'''| [[Ciclopirox how supplied|How Supplied]]''' | '''| [[Ciclopirox how supplied|How Supplied]]''' | ||
'''| [[Ciclopirox labels and packages|Labels and Packages]]''' | '''| [[Ciclopirox labels and packages|Labels and Packages]]''' | ||
==Mechanism of | ==Mechanism of action== | ||
In contrast to the [[azole]]s and other antimycotic drugs, the [[mechanism of action]] of ciclopirox is poorly understood.<ref>{{cite journal | author = Niewerth M, Kunze D, Seibold M, Schaller M, Korting HC, Hube B. | title = Ciclopirox Olamine Treatment Affects the Expression Pattern of Candida albicans Genes Encoding Virulence Factors, Iron Metabolism Proteins, and Drug Resistance Factors | journal = Antimicrobial Agents and Chemotherapy | year = 2003 | month = June | volume = 47 | issue = 6 | pages = 1805–17 | doi = 10.1128/AAC.47.6.1805-1817.2003 | pmid = 12760852 | pmc = 155814}}</ref> However, loss of function of certain [[catalase]] and [[peroxidase]] enzymes has been implicated as the mechanism of action, as well as various other components of cellular metabolism. | |||
==References== | ==References== | ||
Revision as of 01:13, 6 January 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Zaghw, M.D. [2]
Overview
Ciclopirox olamine is a synthetic antifungal agent for topical dermatologic treatment of superficial mycoses.
Category
Antifungal
US Brand Names
Ciclodan®
FDA Package Insert
Description | Clinical Pharmacology | Microbiology | Indications and Usage | Contraindications | Warnings and Precautions | Adverse Reactions | Dosage and Administration | How Supplied | Labels and Packages
Mechanism of action
In contrast to the azoles and other antimycotic drugs, the mechanism of action of ciclopirox is poorly understood.[1] However, loss of function of certain catalase and peroxidase enzymes has been implicated as the mechanism of action, as well as various other components of cellular metabolism.
References
- ↑ Niewerth M, Kunze D, Seibold M, Schaller M, Korting HC, Hube B. (2003). "Ciclopirox Olamine Treatment Affects the Expression Pattern of Candida albicans Genes Encoding Virulence Factors, Iron Metabolism Proteins, and Drug Resistance Factors". Antimicrobial Agents and Chemotherapy. 47 (6): 1805–17. doi:10.1128/AAC.47.6.1805-1817.2003. PMC 155814. PMID 12760852. Unknown parameter
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