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Other diagnostic studies for chronic myelogenous leukemia include [[bone marrow aspiration]] and [[biopsy]], [[lumbar puncture]], and [[lymph node biopsy]].
Other diagnostic studies for chronic myelogenous leukemia include [[bone marrow aspiration]] and [[biopsy]], [[lumbar puncture]], and [[lymph node biopsy]].
==Other diagnostic studies==
==Other diagnostic studies==
Other diagnostic studies for chronic myelogenous leukemia include:
Other diagnostic studies for chronic myelogenous leukemia include:<ref name="cancer.ca">Canadian Cancer Society.2015.http://www.cancer.ca/en/cancer-information/cancer-type/leukemia-chronic-myelogenous-cml/diagnosis/?region=ab</ref>
*[[Bone marrow aspiration]] and [[biopsy]]
*[[Bone marrow aspiration]] and [[biopsy]]
:*Used to detect and/or determine the type of leukemic cells
:*Used to detect and/or determine the type of leukemic cells
Line 12: Line 12:
*[[Lymph node biopsy]]
*[[Lymph node biopsy]]
:*Used to detect and/or determine the type of leukemic cells  
:*Used to detect and/or determine the type of leukemic cells  
[[Image:CDR533336-571.jpg|thumb|left|200px|[[Philadelphia chromosome]]. A piece of chromosome 9 and a piece of chromosome 22 break off and trade places. The bcr-abl gene is formed on chromosome 22 where the piece of chromosome 9 attaches. The changed chromosome 22 is called the [[Philadelphia chromosome]]{{-}}
[http://www.cancer.gov/cancertopics/pdq/treatment/CML/patient/ Source].]] {{-}}
Controversy exists over so-called ''Ph-negative'' CML, or cases of suspected CML in which the Philadelphia chromosome cannot be detected. Many such patients in fact have complex chromosomal abnormalities which mask the (9;22) translocation, or have evidence of the translocation by [[fluorescent in situ hybridization|FISH]] or [[RT-PCR]] in spite of normal routine karyotyping.<ref>{{cite journal|title=Clinical features at diagnosis in 430 patients with chronic myeloid leukaemia seen at a referral centre over a 16-year period|author=Savage DG; Szydlo RM; Goldman JM|journal=Br J Haematol|date=1997|volume=96|issue=1|pages=111-116|pmid=9012696}}</ref> The small subset of patients without detectable molecular evidence of bcr-abl fusion may be better classified as having an undifferentiated myelodysplastic/myeloproliferative disorder, as their clinical course tends to be different from patients with CML.<ref name="WHO">{{cite journal|title=Proposals and rationale for revision of the World Health Organization diagnostic criteria for polycythemia vera, essential thrombocythemia, and primary myelofibrosis: recommendations from an ad hoc international expert pane|author=Tefferi A, Thiele J, Orazi A, Kvasnicka HM, Barbui T, Hanson CA, Barosi G, Verstovsek S, Birgegard G, Mesa R, Reilly JT, Gisslinger H, Vannucchi AM, Cervantes F, Finazzi G, Hoffman R, Gilliland DG, Bloomfield CD, Vardiman JW|date=2007|journal=Blood|volume=110|issue=4|pages=1092-1097|pmid=17488875}}</ref>
<div align="left">
<gallery heights="175" widths="175">
Image:CML 0001.jpg|Chronic myelogenous leukemia
Image:CML 0002.jpg|Chronic myelogenous leukemia
Image:CMMoL 0001.jpg|Chronic myelomonocytic leukemia ( CMMoL)
</gallery>
</div>
==Gallery==
==Gallery==
 
<gallery widths=400px class="center">
<gallery>
CDR554337-274.jpg| Bone marrow aspiration and biopsy. After a small area of skin is numbed, a Jamshidi needle (a long, hollow needle) is inserted into the patient’s hip bone. Samples of blood, bone, and bone marrow are removed for examination under a microscope.
 
Image: Human herpesvirus03.jpeg| Blast crisis of chronic myelogenous leukemia (CML). <SMALL><SMALL>''[http://phil.cdc.gov/phil/home.asp From Public Health Image Library (PHIL).] ''<ref name=PHIL> {{Cite web | title = Public Health Image Library (PHIL) | url = http://phil.cdc.gov/phil/home.asp}}</ref></SMALL></SMALL>
</gallery>
</gallery>


Revision as of 15:43, 9 October 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]

Overview

Other diagnostic studies for chronic myelogenous leukemia include bone marrow aspiration and biopsy, lumbar puncture, and lymph node biopsy.

Other diagnostic studies

Other diagnostic studies for chronic myelogenous leukemia include:[1]

  • Used to detect and/or determine the type of leukemic cells
  • Used to detect and/or determine the type of leukemic cells

Gallery

  • Bone marrow aspiration and biopsy. After a small area of skin is numbed, a Jamshidi needle (a long, hollow needle) is inserted into the patient’s hip bone. Samples of blood, bone, and bone marrow are removed for examination under a microscope.

    Bone marrow aspiration and biopsy. After a small area of skin is numbed, a Jamshidi needle (a long, hollow needle) is inserted into the patient’s hip bone. Samples of blood, bone, and bone marrow are removed for examination under a microscope.

References

  1. ↑ Canadian Cancer Society.2015.http://www.cancer.ca/en/cancer-information/cancer-type/leukemia-chronic-myelogenous-cml/diagnosis/?region=ab


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