Chronic lymphocytic leukemia clinical staging: Difference between revisions

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{{CMG}} {{AE}}{{HL}}
{{CMG}} {{AE}}{{HL}}
==Overview==
==Overview==
==Staging System==
==Staging System==
===Rai Staging System===
According to the Rai Staging System, there are five stages of chronic lymphocytic leukemia based on the degree of [[lymphocytosis]], [[hemoglobin]] level, [[platelet]]s level, the presence of [[splenomegaly]], and the presence of [[lymphadenopathy]].<ref name="pmid1139039">{{cite journal| author=Rai KR, Sawitsky A, Cronkite EP, Chanana AD, Levy RN, Pasternack BS| title=Clinical staging of chronic lymphocytic leukemia. | journal=Blood | year= 1975 | volume= 46 | issue= 2 | pages= 219-34 | pmid=1139039 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1139039  }} </ref>
{| style="border: 0px; font-size: 90%; margin: 3px; width: 1000px"
|valign=top|
|+
! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|Stage}}
! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|Hemoglobin Level}}
! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|Platelets Level}}
! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|Lymphocytosis}}
! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|Splenomegaly}}
! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|Lymphadenopathy}}
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center|
Stage 0
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
>11 g/dL
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
>100,000/L
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
Present
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
Absent
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
Absent
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center|
Stage 1
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
>11 g/dL
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
>100,000/L
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
Present
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
Absent
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
Present
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center|
Stage 2
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
>11 g/dL
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
>100,000/L
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
Present
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
Present
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
Present or absent
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center|
Stage 3
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
<11 g/dL
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
>100,000/L
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
Present
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
Present or absent
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
Present or absent
|-


| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center|
Stage 4
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
<11 g/dL or >11g/dL
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
<100,000/L
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
Present
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
Present or absent
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
Present or absent
|}
== References ==
== References ==
{{reflist|2}}
{{reflist|2}}

Revision as of 18:38, 14 October 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]

Overview

Staging System

Rai Staging System

According to the Rai Staging System, there are five stages of chronic lymphocytic leukemia based on the degree of lymphocytosis, hemoglobin level, platelets level, the presence of splenomegaly, and the presence of lymphadenopathy.[1]

Stage Hemoglobin Level Platelets Level Lymphocytosis Splenomegaly Lymphadenopathy

Stage 0

>11 g/dL

>100,000/L

Present

Absent

Absent

Stage 1

>11 g/dL

>100,000/L

Present

Absent

Present

Stage 2

>11 g/dL

>100,000/L

Present

Present

Present or absent

Stage 3

<11 g/dL

>100,000/L

Present

Present or absent

Present or absent

Stage 4

<11 g/dL or >11g/dL

<100,000/L

Present

Present or absent

Present or absent

References

  1. ↑ Rai KR, Sawitsky A, Cronkite EP, Chanana AD, Levy RN, Pasternack BS (1975). "Clinical staging of chronic lymphocytic leukemia". Blood. 46 (2): 219–34. PMID 1139039.

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