Chlorothiazide (oral suspension)

{{DrugProjectFormSinglePage |authorTag=Kiran Singh, M.D. [1] |genericName=chlorothiazide |aOrAn=a |indicationType=treatment |hasBlackBoxWarning=Yes |adverseReactions= |blackBoxWarningTitle=ConditionName: |blackBoxWarningBody=ConditionName:

• Content

|fdaLIADAdult=* DIURIL is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy.

• DIURIL has also been found useful in [[edema due to various forms of renal dysfunction such as nephrotic syndrome, acute glomerulonephritis, and chronic renal failure.

DIURIL is indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effectiveness of other antihypertensive drugs in the more severe forms of hypertension.

Use in Pregnancy. Routine use of diuretics during normal pregnancy is inappropriate and exposes mother and fetus to unnecessary hazard. Diuretics do not prevent development of toxemia of pregnancy and there is no satisfactory evidence that they are useful in the treatment of toxemia.

Edema during pregnancy may arise from pathologic causes or from the physiologic and mechanical consequences of pregnancy. Thiazides are indicated in pregnancy when edema is due to pathologic causes, just as they are in the absence of pregnancy (see PRECAUTIONS, PREGNANCY). Dependent edema in pregnancy, resulting from restriction of venous return by the gravid uterus, is properly treated through elevation of the lower extremities and use of support stockings. Use of diuretics to lower intravascular volume in this instance is illogical and unnecessary. During normal pregnancy there is hypervolemia which is not harmful to the fetus or the mother in the absence of cardiovascular disease. However, it may be associated with edema, rarely generalized edema. If such edema causes discomfort, increased recumbency will often provide relief. Rarely this edema may cause extreme discomfort which is not relieved by rest. In these instances, a short course of diuretic therapy may provide relief and be appropriate. |offLabelAdultGuideSupport======Condition1=====

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Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Chlorothiazide (oral suspension) in adult patients.

|offLabelAdultNoGuideSupport======Condition1=====

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Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Chlorothiazide (oral suspension) in adult patients.

|fdaLIADPed======Condition1=====

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There is limited information regarding FDA-Labeled Use of Chlorothiazide (oral suspension) in pediatric patients.

|offLabelPedGuideSupport======Condition1=====

• Developed by:

• Class of Recommendation:

• Strength of Evidence:

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Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Chlorothiazide (oral suspension) in pediatric patients.

|offLabelPedNoGuideSupport======Condition1=====

• Dosing Information

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Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Chlorothiazide (oral suspension) in pediatric patients.

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Precautions

• Description

|clinicalTrials=There is limited information regarding Clinical Trial Experience of Chlorothiazide (oral suspension) in the drug label.

Miscellaneous

|postmarketing=There is limited information regarding Postmarketing Experience of Chlorothiazide (oral suspension) in the drug label.

Miscellaneous

|drugInteractions=* Drug

• Description

|useInPregnancyFDA=* Pregnancy Category |useInPregnancyAUS=* Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Chlorothiazide (oral suspension) in women who are pregnant. |useInLaborDelivery=There is no FDA guidance on use of Chlorothiazide (oral suspension) during labor and delivery. |useInNursing=There is no FDA guidance on the use of Chlorothiazide (oral suspension) with respect to nursing mothers. |useInPed=There is no FDA guidance on the use of Chlorothiazide (oral suspension) with respect to pediatric patients. |useInGeri=There is no FDA guidance on the use of Chlorothiazide (oral suspension) with respect to geriatric patients. |useInGender=There is no FDA guidance on the use of Chlorothiazide (oral suspension) with respect to specific gender populations. |useInRace=There is no FDA guidance on the use of Chlorothiazide (oral suspension) with respect to specific racial populations. |useInRenalImpair=There is no FDA guidance on the use of Chlorothiazide (oral suspension) in patients with renal impairment. |useInHepaticImpair=There is no FDA guidance on the use of Chlorothiazide (oral suspension) in patients with hepatic impairment. |useInReproPotential=There is no FDA guidance on the use of Chlorothiazide (oral suspension) in women of reproductive potentials and males. |useInImmunocomp=There is no FDA guidance one the use of Chlorothiazide (oral suspension) in patients who are immunocompromised.

|administration=* Oral

• Intravenous

|monitoring=There is limited information regarding Monitoring of Chlorothiazide (oral suspension) in the drug label.

• Description

|IVCompat=There is limited information regarding IV Compatibility of Chlorothiazide (oral suspension) in the drug label.

|overdose====Acute Overdose===

Signs and Symptoms

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Management

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Chronic Overdose

There is limited information regarding Chronic Overdose of Chlorothiazide (oral suspension) in the drug label.

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File:Chlorothiazide (oral suspension)01.png

This image is provided by the National Library of Medicine.

|PD=There is limited information regarding Pharmacodynamics of Chlorothiazide (oral suspension) in the drug label.

|PK=There is limited information regarding Pharmacokinetics of Chlorothiazide (oral suspension) in the drug label.

|nonClinToxic=There is limited information regarding Nonclinical Toxicology of Chlorothiazide (oral suspension) in the drug label.

|clinicalStudies=There is limited information regarding Clinical Studies of Chlorothiazide (oral suspension) in the drug label.

|howSupplied=* |packLabel= |fdaPatientInfo=There is limited information regarding Patient Counseling Information of Chlorothiazide (oral suspension) in the drug label.

|alcohol=* Alcohol-Chlorothiazide (oral suspension) interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

|brandNames=* DIURIL ®

|lookAlike=* A® — B®

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