Chloride potassium symporter 4: Difference between revisions

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Revision as of 13:29, 30 August 2017

Potassium-chloride transporter, member 4 is a chloride potassium symporter. It is encoded by the gene SLC12A4.^[1]

References

↑ "Entrez Gene: SLC12A4 solute carrier family 12 (potassium/chloride transporters), member 4".

Larsen F, Solheim J, Kristensen T, et al. (1994). "A tight cluster of five unrelated human genes on chromosome 16q22.1". Hum. Mol. Genet. 2 (10): 1589–95. doi:10.1093/hmg/2.10.1589. PMID 8268911.
Gillen CM, Brill S, Payne JA, Forbush B (1996). "Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family". J. Biol. Chem. 271 (27): 16237–44. doi:10.1074/jbc.271.27.16237. PMID 8663127.
Pellegrino CM, Rybicki AC, Musto S, et al. (1998). "Molecular identification and expression of erythroid K:Cl cotransporter in human and mouse erythroleukemic cells". Blood Cells Mol. Dis. 24 (1): 31–40. doi:10.1006/bcmd.1998.0168. PMID 9516379.
Su W, Shmukler BE, Chernova MN, et al. (1999). "Mouse K-Cl cotransporter KCC1: cloning, mapping, pathological expression, and functional regulation". Am. J. Physiol. 277 (5 Pt 1): C899–912. PMID 10564083.
Casula S, Shmukler BE, Wilhelm S, et al. (2001). "A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity". J. Biol. Chem. 276 (45): 41870–8. doi:10.1074/jbc.M107155200. PMID 11551954.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Bräuer M, Frei E, Claes L, et al. (2003). "Influence of K-Cl cotransporter activity on activation of volume-sensitive Cl⁻ channels in human osteoblasts". Am. J. Physiol., Cell Physiol. 285 (1): C22–30. doi:10.1152/ajpcell.00289.2002. PMID 12637262.
Shen MR, Chou CY, Hsu KF, et al. (2003). "KCl cotransport is an important modulator of human cervical cancer growth and invasion". J. Biol. Chem. 278 (41): 39941–50. doi:10.1074/jbc.M308232200. PMID 12902337.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Zhou GP, Wong C, Su R, et al. (2004). "Human potassium chloride cotransporter 1 (SLC12A4) promoter is regulated by AP-2 and contains a functional downstream promoter element". Blood. 103 (11): 4302–9. doi:10.1182/blood-2003-01-0107. PMID 14976052.
Khan AI, Drew C, Ball SE, et al. (2005). "Oxygen dependence of K⁺–Cl⁻ cotransport in human red cell ghosts and sickle cells". Bioelectrochemistry (Amsterdam, Netherlands). 62 (2): 141–6. doi:10.1016/j.bioelechem.2003.07.005. PMID 15039017.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Shen MR, Lin AC, Hsu YM, et al. (2004). "Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells". J. Biol. Chem. 279 (38): 40017–25. doi:10.1074/jbc.M406706200. PMID 15262997.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

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[entrez-1] "Entrez Gene: SLC12A4 solute carrier family 12 (potassium/chloride transporters), member 4".

[1]

@@ Line 1: / Line 1: @@
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+{{Underlinked|date=May 2016}}
-{{PBB_Controls
+{{Infobox_gene}}
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-| update_summary = no
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+'''Potassium-chloride transporter, member 4''' is a [[chloride potassium symporter]]. It is encoded by the gene '''SLC12A4'''.<ref name="entrez">{{cite web | title = Entrez Gene: SLC12A4 solute carrier family 12 (potassium/chloride transporters), member 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6560| accessdate = }}</ref>
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Solute carrier family 12 (potassium/chloride transporters), member 4
- | HGNCid = 10913
- | Symbol = SLC12A4
- | AltSymbols =; FLJ40489; KCC1
- | OMIM = 604119
- | ECnumber =
- | Homologene = 21056
- | MGIid = 1309465
- | Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0015293 |text = symporter activity}} {{GNF_GO|id=GO:0015379 |text = potassium:chloride symporter activity}} {{GNF_GO|id=GO:0030955 |text = potassium ion binding}}
- | Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
- | Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006813 |text = potassium ion transport}} {{GNF_GO|id=GO:0006814 |text = sodium ion transport}} {{GNF_GO|id=GO:0006821 |text = chloride transport}} {{GNF_GO|id=GO:0006873 |text = cell ion homeostasis}} {{GNF_GO|id=GO:0006884 |text = regulation of cell volume}} {{GNF_GO|id=GO:0008217 |text = blood pressure regulation}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 6560
-    | Hs_Ensembl =
-    | Hs_RefseqProtein = NP_005063
-    | Hs_RefseqmRNA = NM_005072
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr =
-    | Hs_GenLoc_start =
-    | Hs_GenLoc_end =
-    | Hs_Uniprot =
-    | Mm_EntrezGene = 20498
-    | Mm_Ensembl = ENSMUSG00000017765
-    | Mm_RefseqmRNA = NM_009195
-    | Mm_RefseqProtein = NP_033221
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 8
-    | Mm_GenLoc_start = 108832721
-    | Mm_GenLoc_end = 108855173
-    | Mm_Uniprot = Q3TJG5
-  }}
-}}
-'''Potassium-chloride transporter, member 4''' is a [[chloride potassium symporter]]. It is encoded by the gene '''SLC12A4'''.<ref name="entrez">{{cite web | title = Entrez Gene: SLC12A4 solute carrier family 12 (potassium/chloride transporters), member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6560| accessdate = }}</ref>
 ==See also==
@@ Line 52: / Line 8: @@
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
-{{PBB_Further_reading
+*{{cite journal  | vauthors=Larsen F, Solheim J, Kristensen T |title=A tight cluster of five unrelated human genes on chromosome 16q22.1. |journal=Hum. Mol. Genet. |volume=2 |issue= 10 |pages= 1589–95 |year= 1994 |pmid= 8268911 |doi=10.1093/hmg/2.10.1589  |display-authors=etal}}
-| citations =
+*{{cite journal  | vauthors=Gillen CM, Brill S, Payne JA, Forbush B |title=Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family. |journal=J. Biol. Chem. |volume=271 |issue= 27 |pages= 16237–44 |year= 1996 |pmid= 8663127 |doi=10.1074/jbc.271.27.16237  }}
-*{{cite journal  | author=Larsen F, Solheim J, Kristensen T, ''et al.'' |title=A tight cluster of five unrelated human genes on chromosome 16q22.1. |journal=Hum. Mol. Genet. |volume=2 |issue= 10 |pages= 1589-95 |year= 1994 |pmid= 8268911 |doi=  }}
+*{{cite journal  | vauthors=Pellegrino CM, Rybicki AC, Musto S |title=Molecular identification and expression of erythroid K:Cl cotransporter in human and mouse erythroleukemic cells. |journal=Blood Cells Mol. Dis. |volume=24 |issue= 1 |pages= 31–40 |year= 1998 |pmid= 9516379 |doi= 10.1006/bcmd.1998.0168 |display-authors=etal}}
-*{{cite journal  | author=Gillen CM, Brill S, Payne JA, Forbush B |title=Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family. |journal=J. Biol. Chem. |volume=271 |issue= 27 |pages= 16237-44 |year= 1996 |pmid= 8663127 |doi=  }}
+*{{cite journal  | vauthors=Su W, Shmukler BE, Chernova MN |title=Mouse K-Cl cotransporter KCC1: cloning, mapping, pathological expression, and functional regulation. |journal=Am. J. Physiol. |volume=277 |issue= 5 Pt 1 |pages= C899–912 |year= 1999 |pmid= 10564083 |doi=  |display-authors=etal}}
-*{{cite journal  | author=Pellegrino CM, Rybicki AC, Musto S, ''et al.'' |title=Molecular identification and expression of erythroid K:Cl cotransporter in human and mouse erythroleukemic cells. |journal=Blood Cells Mol. Dis. |volume=24 |issue= 1 |pages= 31-40 |year= 1998 |pmid= 9516379 |doi= 10.1006/bcmd.1998.0168 }}
+*{{cite journal  | vauthors=Casula S, Shmukler BE, Wilhelm S |title=A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity. |journal=J. Biol. Chem. |volume=276 |issue= 45 |pages= 41870–8 |year= 2001 |pmid= 11551954 |doi= 10.1074/jbc.M107155200 |display-authors=etal}}
-*{{cite journal  | author=Su W, Shmukler BE, Chernova MN, ''et al.'' |title=Mouse K-Cl cotransporter KCC1: cloning, mapping, pathological expression, and functional regulation. |journal=Am. J. Physiol. |volume=277 |issue= 5 Pt 1 |pages= C899-912 |year= 1999 |pmid= 10564083 |doi=  }}
+*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
-*{{cite journal  | author=Casula S, Shmukler BE, Wilhelm S, ''et al.'' |title=A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity. |journal=J. Biol. Chem. |volume=276 |issue= 45 |pages= 41870-8 |year= 2001 |pmid= 11551954 |doi= 10.1074/jbc.M107155200 }}
+*{{cite journal  | vauthors=Bräuer M, Frei E, Claes L |title=Influence of K-Cl cotransporter activity on activation of  volume-sensitive Cl<sup>−</sup> channels in human osteoblasts |journal=Am. J. Physiol., Cell Physiol. |volume=285 |issue= 1 |pages= C22–30 |year= 2003 |pmid= 12637262 |doi= 10.1152/ajpcell.00289.2002 |display-authors=etal}}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  | vauthors=Shen MR, Chou CY, Hsu KF |title=KCl cotransport is an important modulator of human cervical cancer growth and invasion |journal=J. Biol. Chem. |volume=278 |issue= 41 |pages= 39941–50 |year= 2003 |pmid= 12902337 |doi= 10.1074/jbc.M308232200 |display-authors=etal}}
-*{{cite journal  | author=Bräuer M, Frei E, Claes L, ''et al.'' |title=Influence of K-Cl cotransporter activity on activation of volume-sensitive Cl- channels in human osteoblasts. |journal=Am. J. Physiol., Cell Physiol. |volume=285 |issue= 1 |pages= C22-30 |year= 2003 |pmid= 12637262 |doi= 10.1152/ajpcell.00289.2002 }}
+*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
-*{{cite journal  | author=Shen MR, Chou CY, Hsu KF, ''et al.'' |title=KCl cotransport is an important modulator of human cervical cancer growth and invasion. |journal=J. Biol. Chem. |volume=278 |issue= 41 |pages= 39941-50 |year= 2003 |pmid= 12902337 |doi= 10.1074/jbc.M308232200 }}
+*{{cite journal  | vauthors=Zhou GP, Wong C, Su R |title=Human potassium chloride cotransporter 1 (SLC12A4) promoter is regulated by AP-2 and contains a functional downstream promoter element |journal=Blood |volume=103 |issue= 11 |pages= 4302–9 |year= 2004 |pmid= 14976052 |doi= 10.1182/blood-2003-01-0107 |display-authors=etal}}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal  | vauthors=Khan AI, Drew C, Ball SE |title=Oxygen dependence of K<sup>+</sup>–Cl<sup>−</sup> cotransport in human red cell ghosts and sickle cells |journal=Bioelectrochemistry (Amsterdam, Netherlands) |volume=62 |issue= 2 |pages= 141–6 |year= 2005 |pmid= 15039017 |doi= 10.1016/j.bioelechem.2003.07.005 |display-authors=etal}}
-*{{cite journal  | author=Zhou GP, Wong C, Su R, ''et al.'' |title=Human potassium chloride cotransporter 1 (SLC12A4) promoter is regulated by AP-2 and contains a functional downstream promoter element. |journal=Blood |volume=103 |issue= 11 |pages= 4302-9 |year= 2004 |pmid= 14976052 |doi= 10.1182/blood-2003-01-0107 }}
+*{{cite journal  | vauthors=Colland F, Jacq X, Trouplin V |title=Functional Proteomics Mapping of a Human Signaling Pathway |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104  | pmc=442148 |display-authors=etal}}
-*{{cite journal  | author=Khan AI, Drew C, Ball SE, ''et al.'' |title=Oxygen dependence of K(+)-Cl- cotransport in human red cell ghosts and sickle cells. |journal=Bioelectrochemistry (Amsterdam, Netherlands) |volume=62 |issue= 2 |pages= 141-6 |year= 2005 |pmid= 15039017 |doi= 10.1016/j.bioelechem.2003.07.005 }}
+*{{cite journal  | vauthors=Shen MR, Lin AC, Hsu YM |title=Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells |journal=J. Biol. Chem. |volume=279 |issue= 38 |pages= 40017–25 |year= 2004 |pmid= 15262997 |doi= 10.1074/jbc.M406706200 |display-authors=etal}}
-*{{cite journal  | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
+*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
-*{{cite journal  | author=Shen MR, Lin AC, Hsu YM, ''et al.'' |title=Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells. |journal=J. Biol. Chem. |volume=279 |issue= 38 |pages= 40017-25 |year= 2004 |pmid= 15262997 |doi= 10.1074/jbc.M406706200 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
-}}
 {{refend}}
+{{ion pumps}}
+{{Membrane transport proteins|g2}}
+[[Category:Solute carrier family]]
 {{membrane-protein-stub}}
-{{{ion pumps}}
-{{Membrane transport proteins}}
-[[Category:Solute carrier family]]

Chloride potassium symporter 4: Difference between revisions

Revision as of 13:29, 30 August 2017

See also

References

Further reading

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