Chancroid differential diagnosis

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Overview

Chancroid must be differentiated from other diseases that cause genital ulcers and lymphadenopathy including syphilis, herpes simplex, dermatologic aspects of Behçet's disease, dermatologic manifestations of Lymphogranuloma venereum, donovanosis, and fixed drug eruption.

Differential Diagnosis of Chancroid

Chancroid must be differentiated from other diseases that cause genital ulcers and lymphadenopathy:

• Syphilis
• Herpes simplex
• Dermatologic aspects of Behçet's disease
• Dermatologic manifestations of Lymphogranuloma venereum
• Donovanosis
• Fixed drug eruption

Syphilitic chancres most closely resemble and chancroid lesion. A comparison is found below:

Clinical Characteristic	Disease
	Syphilitic Chancre	Chancroid
Mode of Transmission	Mainly sexual	Mainly sexual
Cause	Treponema pallidum	Haemophilus ducreyi
Lesion Type	Pustules that may progress to ulcers	Pustules that may progress to ulcers
Lesion Location	Genitals	Typically genitals; may occur on limbs
Lesion Size	Typically 1-2 cm in diameter	Typically 1-2 cm in diameter
Lesion Number	Multiple	1-4
Lesion Exudate	Typically grey/yellow purulent exudate	Typically non-exudative
Lesion Tenderness	Typically indurated	Typically soft

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