Cefixime: Difference between revisions

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{{drugbox
__NOTOC__
| IUPAC_name = (6''R'',7''R'')-7-{[2-(2-amino-1,3-thiazol-4-yl)-2-(carboxy<br>methoxyimino)acetyl]amino}-3-ethenyl-8-oxo-5-thia-<br>1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
{{Cefixime}}
| image = Cefixime.png
{{CMG}}
| CAS_number = 79350-37-1
| ATC_prefix = J01
| ATC_suffix = DD08
| ATC_supplemental =
| PubChem = 54362
| DrugBank = APRD00583
| C = 16 | H = 15 | N = 5 | O = 7 | S = 2
| molecular_weight = 453.452 g/mol
| bioavailability = 40% to 50%
| protein_bound = Approximately 60%
| metabolism =
| elimination_half-life = Variable<br>Average 3 to 4 hours
| excretion = [[Kidney|Renal]] and biliary
| pregnancy_category = B
| legal_status =
| routes_of_administration = Oral
}}
{{SI}}


==Overview==


'''Cefixime''' is an oral third generation [[cephalosporin]] [[antibiotic]].  It was sold under the trade name '''Suprax''' in the USA, until 2003 when it was taken off the market by drug manufacturer [[Wyeth]] after its [[patent]] expired. the oral suspension form of "Suprax" was re-launched by Lupin in the USA.  Cefixime is still available in [[Canada]].  It is used to treat [[gonorrhea]]<ref name="McMillan-2007">{{cite journal | author=McMillan A, Young H. | title=The treatment of pharyngeal gonorrhoea with a single oral dose of cefixime. | journal=Int J STD AIDS | year=2007 | volume=18 | issue=4 | pages=253-4 | id=PMID 17509176}}</ref>, [[tonsilitis]]<ref name="Adam-1995">{{cite journal | author=Adam D, Hostalek U, Tröster K. | title=5-day cefixime therapy for bacterial pharyngitis and/or tonsillitis: comparison with 10-day penicillin V therapy. | journal=Infection | year=1995 | volume=23 | issue=Suppl 2 | pages=S83-6 | id=PMID 8537138}}</ref>, and [[pharyngitis]]<ref name="Adam-1995" />.
==Category==
Antibacterial
==US Brand Names==
Suprax<sup>®</sup>


==References==
==FDA Package Insert==
<div class="references-small">
{{reflist|2}}</div>


==External links==
'''  [[Cefixime description|Description]]'''
*[http://www.rxlist.com/cgi/generic/cefixime.htm Suprax Online] - Information about cefixime.
'''| [[Cefixime clinical pharmacology|Clinical Pharmacology]]'''
*[http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5146a6.htm Notice to Readers: Discontinuation of Cefixime Tablets --- United States] - A FDA report alerting physicians about the discontinuation of cefixime.
'''| [[Cefixime microbiology|Microbiology]]'''
 
'''| [[Cefixime indications and usage|Indications and Usage]]'''
{{CephalosporinAntiBiotics}}
'''| [[Cefixime contraindications|Contraindications]]'''
 
'''| [[Cefixime warnings and precautions|Warnings and Precautions]]'''
[[Category:Cephalosporin antibiotics]]
'''| [[Cefixime adverse reactions|Adverse Reactions]]'''
[[Category:Thiazoles]]
'''| [[Cefixime drug interactions|Drug Interactions]]'''
'''| [[Cefixime overdosage|Overdosage]]'''
'''| [[Cefixime clinical studies|Clinical Studies]]'''
'''| [[Cefixime dosage and administration|Dosage and Administration]]'''
'''| [[Cefixime how supplied|How Supplied]]'''
'''| [[Cefixime labels and packages|Labels and Packages]]'''


==References==


{{Reflist|2}}


[[pl:Cefiksym]]
[[Category:Antibiotics]]
[[pt:Cefixima]]
[[Category:Wikinfect]]
[[th:เซฟิกซิม]]
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{{WS}}

Revision as of 19:57, 5 January 2014