Cefalexin

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Cefalexin
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Clinical data
Pregnancy
category
  • AU: A
  • US: B (No risk in non-human studies)
Routes of
administration
Oral
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)
  • UK: POM (Prescription only)
Pharmacokinetic data
BioavailabilityWell absorbed
Metabolism90% excreted unchanged
Elimination half-life0.9 hours
ExcretionRenal
Identifiers
CAS Number
PubChem CID
DrugBank
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC16H17N3O4S
Molar mass347.39 g/mol

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Overview

Cefalexin (INN) (IPA: Template:IPA) or cephalexin (USAN) is a first-generation cephalosporin antibiotic. It is an orally-administered agent with a similar antimicrobial spectrum to the intravenous agents cefalotin and cefazolin. It is commonly marketed under the trade name Keflex (Lilly) or Sporidex (Ranbaxy).

Clinical use

Indications

Cefalexin is used to treat urinary tract infections, respiratory tract infections (including sinusitis, otitis media, pharyngitis, tonsillitis and pneumonia), skin and soft tissue infections.

Although it is not generally considered first-line therapy for any indication, it is a useful alternative to penicillins in patients with penicillin hypersensitivity. There is, however, cross-reactivity in 10% of patients with hypersensitivity to penicillins and carbapenems.

Formulations

Cefalexin is commonly marketed as tablets(250 mg and 500 mg), tablets, and powder for oral suspension (125 mg/5 mL and 250 mg/5 mL).

Cephalexin is being marketed as Keflex® 750 mg as "taken twice per day". The advantage of Keflex 750 is that it provides the same total daily dose most health care professionals prescribe with only two capsules per day. By making Keflex 750 convenient for patients, compliance may be improved with this new dosing option. Keflex 750 is covered by most major insurers with an average copay of between $20 and $25. Retail price is approximately $45 for a 20 capsule supply.

It is marketed by generic pharmaceutical manufacturers under a wide range of brand names, including: Apo-Cephalex, Biocef, Cefanox, Ceporex, Cephabos, Cilex, Ialex, Ibilex, Keflet, Keflex, Keforal, Keftab, Keftal, Lopilexin, Novo-Lexin, Ospexin, Zephalexin, Panixine Disperdose and Sporidex.

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