Caveolin-1 is a protein that in humans is encoded by the CAV1gene.[1]
The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene.[2]
↑Fra AM, Mastroianni N, Mancini M, Pasqualetto E, Sitia R (May 1999). "Human caveolin-1 and caveolin-2 are closely linked genes colocalized with WI-5336 in a region of 7q31 frequently deleted in tumors". Genomics. 56 (3): 355–6. doi:10.1006/geno.1998.5723. PMID10087206.
↑Li, Shengwen; Okamoto T; Chun M; Sargiacomo M; Casanova JE; Hansen SH; Nishimoto I; Lisanti MP (1995). "Evidence for a regulated interaction between heterotrimeric G proteins and caveolin". J. Biol. Chem. 270 (26): 15693–701. doi:10.1074/jbc.270.26.15693. PMID7797570.
↑ 4.04.1Li, Shengwen; Couet J; Lisanti MP. (15 Nov 1996). "Src tyrosine kinases, Galpha subunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases". J. Biol. Chem. 271 (46): 29182–90. doi:10.1074/jbc.271.46.29182. PMID8910575.
↑Li, Shengwen; Song KS; Lisanti MP. (5 Jan 1996). "Expression and characterization of recombinant caveolin. Purification by polyhistidine tagging and cholesterol-dependent incorporation into defined lipid membranes". J. Biol. Chem. 271 (1): 568–73. doi:10.1074/jbc.271.1.568. PMID8550621.
↑Razani, B; Zhang X L; Bitzer M; von Gersdorff G; Böttinger E P; Lisanti M P (March 2001). "Caveolin-1 regulates transforming growth factor (TGF)-beta/SMAD signaling through an interaction with the TGF-beta type I receptor". J. Biol. Chem. United States. 276 (9): 6727–38. doi:10.1074/jbc.M008340200. ISSN0021-9258. PMID11102446.
↑García-Cardeña, G; Fan R; Stern D F; Liu J; Sessa W C (November 1996). "Endothelial nitric oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin-1". J. Biol. Chem. UNITED STATES. 271 (44): 27237–40. doi:10.1074/jbc.271.44.27237. ISSN0021-9258. PMID8910295.
↑Lu, M L; Schneider M C; Zheng Y; Zhang X; Richie J P (April 2001). "Caveolin-1 interacts with androgen receptor. A positive modulator of androgen receptor mediated transactivation". J. Biol. Chem. United States. 276 (16): 13442–51. doi:10.1074/jbc.M006598200. ISSN0021-9258. PMID11278309.
↑Ikezu, T; Trapp B D; Song K S; Schlegel A; Lisanti M P; Okamoto T (April 1998). "Caveolae, plasma membrane microdomains for alpha-secretase-mediated processing of the amyloid precursor protein". J. Biol. Chem. UNITED STATES. 273 (17): 10485–95. doi:10.1074/jbc.273.17.10485. ISSN0021-9258. PMID9553108.
↑Schubert, Anne-Lane; Schubert William; Spray David C; Lisanti Michael P (May 2002). "Connexin family members target to lipid raft domains and interact with caveolin-1". Biochemistry. United States. 41 (18): 5754–64. doi:10.1021/bi0121656. ISSN0006-2960. PMID11980479.
↑Couet, J; Sargiacomo M; Lisanti M P (November 1997). "Interaction of a receptor tyrosine kinase, EGF-R, with caveolins. Caveolin binding negatively regulates tyrosine and serine/threonine kinase activities". J. Biol. Chem. UNITED STATES. 272 (48): 30429–38. doi:10.1074/jbc.272.48.30429. ISSN0021-9258. PMID9374534.
↑Yamaguchi, Tomohiro; Murata Yasunobu; Fujiyoshi Yoshinori; Doi Tomoko (April 2003). "Regulated interaction of endothelin B receptor with caveolin-1". Eur. J. Biochem. Germany. 270 (8): 1816–27. doi:10.1046/j.1432-1033.2003.03544.x. ISSN0014-2956. PMID12694195.
↑ 14.014.1Yamamoto, M; Toya Y; Jensen R A; Ishikawa Y (March 1999). "Caveolin is an inhibitor of platelet-derived growth factor receptor signaling". Exp. Cell Res. UNITED STATES. 247 (2): 380–8. doi:10.1006/excr.1998.4379. ISSN0014-4827. PMID10066366.
↑Liou, J Y; Deng W G; Gilroy D W; Shyue S K; Wu K K (September 2001). "Colocalization and interaction of cyclooxygenase-2 with caveolin-1 in human fibroblasts". J. Biol. Chem. United States. 276 (37): 34975–82. doi:10.1074/jbc.M105946200. ISSN0021-9258. PMID11432874.
↑Feng, X; Gaeta M L; Madge L A; Yang J H; Bradley J R; Pober J S (March 2001). "Caveolin-1 associates with TRAF2 to form a complex that is recruited to tumor necrosis factor receptors". J. Biol. Chem. United States. 276 (11): 8341–9. doi:10.1074/jbc.M007116200. ISSN0021-9258. PMID11112773.
↑Cao, Haiming; Courchesne William E; Mastick Cynthia Corley (March 2002). "A phosphotyrosine-dependent protein interaction screen reveals a role for phosphorylation of caveolin-1 on tyrosine 14: recruitment of C-terminal Src kinase". J. Biol. Chem. United States. 277 (11): 8771–4. doi:10.1074/jbc.C100661200. ISSN0021-9258. PMID11805080.
↑Breuza, Lionel; Corby Séverine; Arsanto Jean-Pierre; Delgrossi Marie-Hélène; Scheiffele Peter; Le Bivic André (December 2002). "The scaffolding domain of caveolin 2 is responsible for its Golgi localization in Caco-2 cells". J. Cell Sci. England. 115 (Pt 23): 4457–67. doi:10.1242/jcs.00130. ISSN0021-9533. PMID12414992.
↑Scherer, P E; Lewis R Y; Volonte D; Engelman J A; Galbiati F; Couet J; Kohtz D S; van Donselaar E; Peters P; Lisanti M P (November 1997). "Cell-type and tissue-specific expression of caveolin-2. Caveolins 1 and 2 co-localize and form a stable hetero-oligomeric complex in vivo". J. Biol. Chem. UNITED STATES. 272 (46): 29337–46. doi:10.1074/jbc.272.46.29337. ISSN0021-9258. PMID9361015.
↑Zheng, Xiangjian; Bollinger Bollag Wendy (December 2003). "Aquaporin 3 colocates with phospholipase d2 in caveolin-rich membrane microdomains and is downregulated upon keratinocyte differentiation". J. Invest. Dermatol. United States. 121 (6): 1487–95. doi:10.1111/j.1523-1747.2003.12614.x. ISSN0022-202X. PMID14675200.
↑Czarny, M; Fiucci G; Lavie Y; Banno Y; Nozawa Y; Liscovitch M (February 2000). "Phospholipase D2: functional interaction with caveolin in low-density membrane microdomains". FEBS Lett. NETHERLANDS. 467 (2–3): 326–32. doi:10.1016/S0014-5793(00)01174-1. ISSN0014-5793. PMID10675563.
↑Vargas, Leonardo; Nore Beston F; Berglof Anna; Heinonen Juhana E; Mattsson Pekka T; Smith C I Edvard; Mohamed Abdalla J (March 2002). "Functional interaction of caveolin-1 with Bruton's tyrosine kinase and Bmx". J. Biol. Chem. United States. 277 (11): 9351–7. doi:10.1074/jbc.M108537200. ISSN0021-9258. PMID11751885.
↑Zhou, Minglong; Parr Rebecca D; Petrescu Anca D; Payne H Ross; Atshaves Barbara P; Kier Ann B; Ball Judith M; Schroeder Friedhelm (June 2004). "Sterol carrier protein-2 directly interacts with caveolin-1 in vitro and in vivo". Biochemistry. United States. 43 (23): 7288–306. doi:10.1021/bi035914n. ISSN0006-2960. PMID15182174.
↑Couet, Jacque; Li S; Okamoto T; Ikezu T; Lisanti MP. (7 March 1997). "Identification of peptide and protein ligands for the caveolin-scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins". J. Biol. Chem. 272 (10): 6525–33. doi:10.1074/jbc.272.10.6525. PMID9045678.
Razani B, Schlegel A, Liu J, Lisanti MP (2002). "Caveolin-1, a putative tumour suppressor gene". Biochem. Soc. Trans. 29 (Pt 4): 494–9. doi:10.1042/BST0290494. PMID11498016.
Fujimoto T, Kogo H, Nakamura N, Ozeki S (2002). "[Microdomains and caveolin]". Tanpakushitsu Kakusan Koso. 47 (4 Suppl): 326–32. PMID11915322.
Shatz M, Liscovitch M (2004). "Caveolin-1 and cancer multidrug resistance: coordinate regulation of pro-survival proteins?". Leuk. Res. 28 (9): 907–8. doi:10.1016/j.leukres.2004.03.013. PMID15234566.
Frank PG, Lisanti MP (2007). "Caveolin-1 and liver regeneration: role in proliferation and lipogenesis". Cell Cycle. 6 (2): 115–6. doi:10.4161/cc.6.2.3722. PMID17314510.