Carcinoid syndrome laboratory tests

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Laboratory Findings

With a certain degree of clinical suspicion, diagnosis is made primarily by measuring plasma levels of the secreted glycoprotein Chromogranin A, supported by measuring the 24 hour urine levels of 5-HIAA (5-hydroxyindoleacetic acid), a breakdown product of serotonin. Patients with carcinoid syndrome usually excrete >25 mg of 5-HIAA per day.

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