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Latest revision as of 15:27, 18 August 2022

Capillary leak syndrome Microchapters

Home

Patient Information

Overview

Historical Perspective

Pathophysiology

Causes

Differentiating Capillary leak syndrome from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

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Case #1

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: M. Hassan, M.B.B.S

Overview

Patients with capillary leak syndrome present with generalized edema, weight gain, fatigue, and body aches. Physical examination is remarkable from hypotension, rash, pruritus, flushing, jaw claudication. Lung examination may reveal wheezing and prolonged expiratory phase. Cardiac examination may reveal tachycardia, weak peripheral pulses, muffled heart sounds on auscultation due to underlying pericardial effusion, pulsus paradoxus, and pericardial friction rub. The patient may also present with abdominal distention, tenderness, and fluid thrill.

Physical Examination

Patient with capillary leak syndrome usually presents with generalized edema fatigued, and body aches[1]. Physical examination is usually remarkable for hypotension, pleural and pericardial effusion.[1]

Appearence of the Patient

  • Partial or generalized edema may be seen.
  • Weight gain

Vitals

Skin

HEENT

  • Jaw claudication

Neck

  • Unremarkable

Lungs

  • Wheezing may be present
  • Prolonged expiratory phase

Heart

  • Tachycardia
  • Weak peripheral pulses
  • Muffled heart sounds on auscultation due to underlying pericardial effusion
  • Pulsus Paradoxus
  • Pericardial friction rub

Abdomen

  • Abdominal tenderness
  • Abdominal distention
  • Fluid thrill

Extremities

  • Generalized edema

References

  1. 1.0 1.1 Kapoor P, Greipp PT, Schaefer EW, Mandrekar SJ, Kamal AH, Gonzalez-Paz NC; et al. (2010). "Idiopathic systemic capillary leak syndrome (Clarkson's disease): the Mayo clinic experience". Mayo Clin Proc. 85 (10): 905–12. doi:10.4065/mcp.2010.0159. PMC 2947962. PMID 20634497.

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