CST7 (gene)

Cystatin F (leukocystatin)
PDB rendering based on 2ch9.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2ch9​
Identifiers
Symbols	CST7 ; CMAP
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37832
Gene ontology Molecular function Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Cystatin F (leukocystatin), also known as CST7, is a human gene.

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. This gene encodes a glycosylated cysteine protease inhibitor with a putative role in immune regulation through inhibition of a unique target in the hematopoietic system. Expression of the protein has been observed in various human cancer cell lines established from malignant tumors.

Further reading

• Brown WM, Dziegielewska KM (1997). "Friends and relations of the cystatin superfamily--new members and their evolution". Protein Sci. 6 (1): 5–12. PMID 9007972.
• Saitoh E, Isemura S, Sanada K; et al. (1989). "Cystatin superfamily. Evidence that family II cystatin genes are evolutionarily related to family III cystatin genes". Biol. Chem. Hoppe-Seyler. 369 Suppl: 191–7. PMID 3202964.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Thiesse M, Millar SJ, Dickinson DP (1994). "The human type 2 cystatin gene family consists of eight to nine members, with at least seven genes clustered at a single locus on human chromosome 20". DNA Cell Biol. 13 (2): 97–116. PMID 8179826.CS1 maint: Multiple names: authors list (link)
• Halfon S, Ford J, Foster J; et al. (1998). "Leukocystatin, a new Class II cystatin expressed selectively by hematopoietic cells". J. Biol. Chem. 273 (26): 16400–8. PMID 9632704.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ni J, Fernandez MA, Danielsson L; et al. (1998). "Cystatin F is a glycosylated human low molecular weight cysteine proteinase inhibitor". J. Biol. Chem. 273 (38): 24797–804. PMID 9733783.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Morita M, Yoshiuchi N, Arakawa H, Nishimura S (1999). "CMAP: a novel cystatin-like gene involved in liver metastasis". Cancer Res. 59 (1): 151–8. PMID 9892200.CS1 maint: Multiple names: authors list (link)
• Morita M, Hara Y, Tamai Y; et al. (2001). "Genomic construct and mapping of the gene for CMAP (leukocystatin/cystatin F, CST7) and identification of a proximal novel gene, BSCv (C20orf3)". Genomics. 67 (1): 87–91. doi:10.1006/geno.2000.6237. PMID 10945474.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Journet A, Chapel A, Kieffer S; et al. (2001). "Towards a human repertoire of monocytic lysosomal proteins". Electrophoresis. 21 (16): 3411–9. doi:10.1002/1522-2683(20001001)21:16<3411::AID-ELPS3411>3.0.CO;2-M. PMID 11079561.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nathanson CM, Wassélius J, Wallin H, Abrahamson M (2003). "Regulated expression and intracellular localization of cystatin F in human U937 cells". Eur. J. Biochem. 269 (22): 5502–11. PMID 12423348.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cappello F, Gatti E, Camossetto V; et al. (2004). "Cystatin F is secreted, but artificial modification of its C-terminus can induce its endocytic targeting". Exp. Cell Res. 297 (2): 607–18. doi:10.1016/j.yexcr.2004.03.048. PMID 15212960.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Langerholc T, Zavasnik-Bergant V, Turk B; et al. (2005). "Inhibitory properties of cystatin F and its localization in U937 promonocyte cells". FEBS J. 272 (6): 1535–45. doi:10.1111/j.1742-4658.2005.04594.x. PMID 15752368.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schüttelkopf AW, Hamilton G, Watts C, van Aalten DM (2006). "Structural basis of reduction-dependent activation of human cystatin F.". J. Biol. Chem. 281 (24): 16570–5. doi:10.1074/jbc.M601033200. PMID 16601115.CS1 maint: Multiple names: authors list (link)