CLUAP1: Difference between revisions
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*{{cite journal |vauthors=Ishikawa K, Nagase T, Suyama M |title=Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro |journal=DNA Research |volume=5 |issue= 3 |pages= 169–76 |year= 1998 |pmid= 9734811 |doi= 10.1093/dnares/5.3.169}} | *{{cite journal |vauthors=Ishikawa K, Nagase T, Suyama M |title=Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro |journal=DNA Research |volume=5 |issue= 3 |pages= 169–76 |year= 1998 |pmid= 9734811 |doi= 10.1093/dnares/5.3.169}} | ||
*{{cite journal |vauthors=Takahashi M, Lin YM, Nakamura Y, Furukawa Y |title=Isolation and characterization of a novel gene CLUAP1 whose expression is frequently upregulated in colon cancer |journal=Oncogene |volume=23 |issue= 57 |pages= 9289–94 |year= 2004 |pmid= 15480429 |doi= 10.1038/sj.onc.1208100 }} | *{{cite journal |vauthors=Takahashi M, Lin YM, Nakamura Y, Furukawa Y |title=Isolation and characterization of a novel gene CLUAP1 whose expression is frequently upregulated in colon cancer |journal=Oncogene |volume=23 |issue= 57 |pages= 9289–94 |year= 2004 |pmid= 15480429 |doi= 10.1038/sj.onc.1208100 }} | ||
*{{cite journal |vauthors=Ishikura H, Ikeda H, Abe H |title=Identification of CLUAP1 as a human osteosarcoma tumor-associated antigen recognized by the humoral immune system |journal=International Journal of Oncology |volume=30 |issue= 2 |pages= 461–7 |year= 2007 |pmid= 17203229 |doi= | *{{cite journal |vauthors=Ishikura H, Ikeda H, Abe H |title=Identification of CLUAP1 as a human osteosarcoma tumor-associated antigen recognized by the humoral immune system |journal=International Journal of Oncology |volume=30 |issue= 2 |pages= 461–7 |year= 2007 |pmid= 17203229 |doi= 10.3892/ijo.30.2.461 }} | ||
{{refend}} | {{refend}} | ||
[[Category:Genes mutated in mice]] | [[Category:Genes mutated in mice]] | ||
Latest revision as of 09:23, 10 January 2019
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| External IDs | GeneCards: [1] | ||||||
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| Species | Human | Mouse | |||||
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| RefSeq (mRNA) |
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| Location (UCSC) | n/a | n/a | |||||
| PubMed search | n/a | n/a | |||||
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Clusterin associated protein 1, also known as CLUAP1, is a human gene.[1]
Model organisms
| Characteristic | Phenotype |
|---|---|
| Homozygote viability | Abnormal |
| Recessive lethal study | Abnormal |
| Fertility | Normal |
| Body weight | Normal |
| Anxiety | Normal |
| Neurological assessment | Normal |
| Grip strength | Normal |
| Hot plate | Normal |
| Dysmorphology | Normal |
| Indirect calorimetry | Normal |
| Glucose tolerance test | Normal |
| Auditory brainstem response | Normal |
| DEXA | Normal |
| Radiography | Abnormal[2] |
| Body temperature | Normal |
| Eye morphology | Normal |
| Clinical chemistry | Normal |
| Plasma immunoglobulins | Abnormal |
| Haematology | Normal |
| Peripheral blood lymphocytes | Normal |
| Micronucleus test | Normal |
| Heart weight | Normal |
| Skin Histopathology | Normal |
| Eye Histopathology | Normal |
| Salmonella infection | Normal[3] |
| Citrobacter infection | Normal[4] |
| All tests and analysis from[5][6] |
Model organisms have been used in the study of CLUAP1 function. A conditional knockout mouse line, called Cluap1tm1a(KOMP)Wtsi[7][8] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[9][10][11]
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[5][12] Twenty six tests were carried out on mutant mice and four significant abnormalities were observed.[5] No homozygous mutant embryos were identified during gestation, and therefore none survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice; both sexes had decreased IgG1 levels while males also displayed abnormal spine curvature resulting in kyphosis.[5]
References
- ↑ "Entrez Gene: clusterin associated protein 1". Retrieved 2011-08-30.
- ↑ "Radiography data for Cluap1". Wellcome Trust Sanger Institute.
- ↑ "Salmonella infection data for Cluap1". Wellcome Trust Sanger Institute.
- ↑ "Citrobacter infection data for Cluap1". Wellcome Trust Sanger Institute.
- ↑ 5.0 5.1 5.2 5.3 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
- ↑ Mouse Resources Portal, Wellcome Trust Sanger Institute.
- ↑ "International Knockout Mouse Consortium".
- ↑ "Mouse Genome Informatics".
- ↑ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
- ↑ Dolgin E (2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
- ↑ Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
- ↑ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.
External links
- Human CLUAP1 genome location and CLUAP1 gene details page in the UCSC Genome Browser.
Further reading
- Rual JF, Venkatesan K, Hao T (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Follit JA, Xu F, Keady BT, Pazour GJ (2009). "Characterization of mouse IFT complex B". Cell Motility and the Cytoskeleton. 66 (8): 457–68. doi:10.1002/cm.20346. PMC 2753169. PMID 19253336.
- Gerhard DS, Wagner L, Feingold EA (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Research. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nature Genetics. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences USA. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ishikawa K, Nagase T, Suyama M (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
- Takahashi M, Lin YM, Nakamura Y, Furukawa Y (2004). "Isolation and characterization of a novel gene CLUAP1 whose expression is frequently upregulated in colon cancer". Oncogene. 23 (57): 9289–94. doi:10.1038/sj.onc.1208100. PMID 15480429.
- Ishikura H, Ikeda H, Abe H (2007). "Identification of CLUAP1 as a human osteosarcoma tumor-associated antigen recognized by the humoral immune system". International Journal of Oncology. 30 (2): 461–7. doi:10.3892/ijo.30.2.461. PMID 17203229.