CGGBP1: Difference between revisions

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{{Infobox_gene}}
{{GNF_Protein_box
'''CGG triplet repeat-binding protein 1''' is a [[protein]] that in humans is encoded by the ''CGGBP1'' [[gene]].<ref name="pmid9201980">{{cite journal | vauthors = Deissler H, Wilm M, Genc B, Schmitz B, Ternes T, Naumann F, Mann M, Doerfler W | title = Rapid protein sequencing by tandem mass spectrometry and cDNA cloning of p20-CGGBP. A novel protein that binds to the unstable triplet repeat 5'-d(CGG)n-3' in the human FMR1 gene | journal = J Biol Chem | volume = 272 | issue = 27 | pages = 16761–8 |date=Jul 1997 | pmid = 9201980 | pmc = | doi =10.1074/jbc.272.27.16761 }}</ref><ref name="pmid14667814">{{cite journal | vauthors = Naumann F, Remus R, Schmitz B, Doerfler W | title = Gene structure and expression of the 5'-(CGG)(n)-3'-binding protein (CGGBP1) | journal = Genomics | volume = 83 | issue = 1 | pages = 106–18 |date=Dec 2003 | pmid = 14667814 | pmc =  | doi =10.1016/S0888-7543(03)00212-X }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CGGBP1 CGG triplet repeat binding protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8545| accessdate = }}</ref>
| image = 
| image_source = 
| PDB =
| Name = CGG triplet repeat binding protein 1
| HGNCid = 1888
| Symbol = CGGBP1
| AltSymbols =; CGGBP; p20-CGGBP
| OMIM = 603363
| ECnumber =
| Homologene = 2718
| MGIid = 2146370
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003690 |text = double-stranded DNA binding}}
  | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}  
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8545
    | Hs_Ensembl =
    | Hs_RefseqProtein = NP_001008391
    | Hs_RefseqmRNA = NM_001008390
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr =
    | Hs_GenLoc_start =   
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 106143
    | Mm_Ensembl = ENSMUSG00000054604
    | Mm_RefseqmRNA = NM_178647
    | Mm_RefseqProtein = NP_848762
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 64794287
    | Mm_GenLoc_end = 64801699
    | Mm_Uniprot = Q8BHG9
  }}
}}
'''CGG triplet repeat binding protein 1''', also known as '''CGGBP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CGGBP1 CGG triplet repeat binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8545| accessdate = }}</ref>


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| section_title =  
| section_title =  
| summary_text = CGGBP1 influences expression of the fragile X mental retardation gene, FMR1 (MIM 309550), by specifically interacting with the 5-prime (CGG)n-3-prime repeat in its 5-prime UTR.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: CGGBP1 CGG triplet repeat binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8545| accessdate = }}</ref>
| summary_text = CGGBP1 influences expression of the fragile X mental retardation gene, FMR1 (MIM 309550), by specifically interacting with the 5-prime (CGG)n-3-prime repeat in its 5-prime UTR.[supplied by OMIM]<ref name="entrez"/>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|CGGBP1}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Meijer H, de Graaff E, Merckx DM, ''et al.'' |title=A deletion of 1.6 kb proximal to the CGG repeat of the FMR1 gene causes the clinical phenotype of the fragile X syndrome. |journal=Hum. Mol. Genet. |volume=3 |issue= 4 |pages= 615-20 |year= 1994 |pmid= 8069307 |doi=  }}
*{{cite journal  | vauthors=Meijer H, de Graaff E, Merckx DM |title=A deletion of 1.6 kb proximal to the CGG repeat of the FMR1 gene causes the clinical phenotype of the fragile X syndrome. |journal=Hum. Mol. Genet. |volume=3 |issue= 4 |pages= 615–20 |year= 1994 |pmid= 8069307 |doi=10.1093/hmg/3.4.615 |display-authors=etal}}
*{{cite journal  | author=Hornstra IK, Nelson DL, Warren ST, Yang TP |title=High resolution methylation analysis of the FMR1 gene trinucleotide repeat region in fragile X syndrome. |journal=Hum. Mol. Genet. |volume=2 |issue= 10 |pages= 1659-65 |year= 1994 |pmid= 8268919 |doi=  }}
*{{cite journal  | vauthors=Hornstra IK, Nelson DL, Warren ST, Yang TP |title=High resolution methylation analysis of the FMR1 gene trinucleotide repeat region in fragile X syndrome. |journal=Hum. Mol. Genet. |volume=2 |issue= 10 |pages= 1659–65 |year= 1994 |pmid= 8268919 |doi=10.1093/hmg/2.10.1659 }}
*{{cite journal  | author=Deissler H, Behn-Krappa A, Doerfler W |title=Purification of nuclear proteins from human HeLa cells that bind specifically to the unstable tandem repeat (CGG)n in the human FMR1 gene. |journal=J. Biol. Chem. |volume=271 |issue= 8 |pages= 4327-34 |year= 1996 |pmid= 8626781 |doi= }}
*{{cite journal  | vauthors=Deissler H, Behn-Krappa A, Doerfler W |title=Purification of nuclear proteins from human HeLa cells that bind specifically to the unstable tandem repeat (CGG)n in the human FMR1 gene. |journal=J. Biol. Chem. |volume=271 |issue= 8 |pages= 4327–34 |year= 1996 |pmid= 8626781 |doi=10.1074/jbc.271.8.4327 }}
*{{cite journal  | author=Deissler H, Wilm M, Genç B, ''et al.'' |title=Rapid protein sequencing by tandem mass spectrometry and cDNA cloning of p20-CGGBP. A novel protein that binds to the unstable triplet repeat 5'-d(CGG)n-3' in the human FMR1 gene. |journal=J. Biol. Chem. |volume=272 |issue= 27 |pages= 16761-8 |year= 1997 |pmid= 9201980 |doi= }}
*{{cite journal  | vauthors=Müller-Hartmann H, Deissler H, Naumann F |title=The human 20-kDa 5'-(CGG)(n)-3'-binding protein is targeted to the nucleus and affects the activity of the FMR1 promoter. |journal=J. Biol. Chem. |volume=275 |issue= 9 |pages= 6447–52 |year= 2000 |pmid= 10692448 |doi=10.1074/jbc.275.9.6447 |display-authors=etal}}
*{{cite journal  | author=Müller-Hartmann H, Deissler H, Naumann F, ''et al.'' |title=The human 20-kDa 5'-(CGG)(n)-3'-binding protein is targeted to the nucleus and affects the activity of the FMR1 promoter. |journal=J. Biol. Chem. |volume=275 |issue= 9 |pages= 6447-52 |year= 2000 |pmid= 10692448 |doi=  }}
*{{cite journal  | vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948 }}
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
*{{cite journal  | vauthors=Wiemann S, Weil B, Wellenreuther R |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R  | pmc=311072 |display-authors=etal}}
*{{cite journal  | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
*{{cite journal  | vauthors=Simpson JC, Wellenreuther R, Poustka A |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 | pmc=1083732 |display-authors=etal}}
*{{cite journal  | author=Simpson JC, Wellenreuther R, Poustka A, ''et al.'' |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287-92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Chen LS, Tassone F, Sahota P, Hagerman PJ |title=The (CGG)n repeat element within the 5' untranslated region of the FMR1 message provides both positive and negative cis effects on in vivo translation of a downstream reporter. |journal=Hum. Mol. Genet. |volume=12 |issue= 23 |pages= 3067–74 |year= 2004 |pmid= 14519687 |doi= 10.1093/hmg/ddg331 }}
*{{cite journal  | author=Chen LS, Tassone F, Sahota P, Hagerman PJ |title=The (CGG)n repeat element within the 5' untranslated region of the FMR1 message provides both positive and negative cis effects on in vivo translation of a downstream reporter. |journal=Hum. Mol. Genet. |volume=12 |issue= 23 |pages= 3067-74 |year= 2004 |pmid= 14519687 |doi= 10.1093/hmg/ddg331 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Naumann F, Remus R, Schmitz B, Doerfler W |title=Gene structure and expression of the 5'-(CGG)(n)-3'-binding protein (CGGBP1). |journal=Genomics |volume=83 |issue= 1 |pages= 106-18 |year= 2004 |pmid= 14667814 |doi=  }}
*{{cite journal  | vauthors=Wiemann S, Arlt D, Huber W |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 | pmc=528930 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Mehrle A, Rosenfelder H, Schupp I |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501 |display-authors=etal}}
*{{cite journal  | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal  | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
}}
}}
{{refend}}
{{refend}}
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Revision as of 09:37, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

CGG triplet repeat-binding protein 1 is a protein that in humans is encoded by the CGGBP1 gene.[1][2][3]

CGGBP1 influences expression of the fragile X mental retardation gene, FMR1 (MIM 309550), by specifically interacting with the 5-prime (CGG)n-3-prime repeat in its 5-prime UTR.[supplied by OMIM][3]

References

  1. ↑ Deissler H, Wilm M, Genc B, Schmitz B, Ternes T, Naumann F, Mann M, Doerfler W (Jul 1997). "Rapid protein sequencing by tandem mass spectrometry and cDNA cloning of p20-CGGBP. A novel protein that binds to the unstable triplet repeat 5'-d(CGG)n-3' in the human FMR1 gene". J Biol Chem. 272 (27): 16761–8. doi:10.1074/jbc.272.27.16761. PMID 9201980.
  2. ↑ Naumann F, Remus R, Schmitz B, Doerfler W (Dec 2003). "Gene structure and expression of the 5'-(CGG)(n)-3'-binding protein (CGGBP1)". Genomics. 83 (1): 106–18. doi:10.1016/S0888-7543(03)00212-X. PMID 14667814.
  3. ↑ 3.0 3.1 "Entrez Gene: CGGBP1 CGG triplet repeat binding protein 1".

External links

Further reading



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