CDH11

Cadherin 11, type 2, OB-cadherin (osteoblast)
PDB rendering based on 2a4c.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2a4c​, 2a4e​
Identifiers
Symbols	CDH11 ; CAD11; CDHOB; OB; OSF-4
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1361
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Cadherin 11, type 2, OB-cadherin (osteoblast), also known as CDH11, is a human gene.

This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance.

Further reading

• Suzuki S, Sano K, Tanihara H (1991). "Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue". Cell Regul. 2 (4): 261–70. PMID 2059658.CS1 maint: Multiple names: authors list (link)
• Tanihara H, Sano K, Heimark RL; et al. (1995). "Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin". Cell Adhes. Commun. 2 (1): 15–26. PMID 7982033.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Okazaki M, Takeshita S, Kawai S; et al. (1994). "Molecular cloning and characterization of OB-cadherin, a new member of cadherin family expressed in osteoblasts". J. Biol. Chem. 269 (16): 12092–8. PMID 8163513.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Getsios S, Chen GT, Stephenson MD; et al. (1998). "Regulated expression of cadherin-6 and cadherin-11 in the glandular epithelial and stromal cells of the human endometrium". Dev. Dyn. 211 (3): 238–47. doi:10.1002/(SICI)1097-0177(199803)211:3<238::AID-AJA5>3.0.CO;2-I. PMID 9520111.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kremmidiotis G, Baker E, Crawford J; et al. (1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity". Genomics. 49 (3): 467–71. doi:10.1006/geno.1998.5281. PMID 9615235.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pishvaian MJ, Feltes CM, Thompson P; et al. (1999). "Cadherin-11 is expressed in invasive breast cancer cell lines". Cancer Res. 59 (4): 947–52. PMID 10029089.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kawaguchi J, Takeshita S, Kashima T; et al. (1999). "Expression and function of the splice variant of the human cadherin-11 gene in subordination to intact cadherin-11". J. Bone Miner. Res. 14 (5): 764–75. PMID 10320525.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Braungart E, Schumacher C, Hartmann E; et al. (2000). "Functional loss of E-cadherin and cadherin-11 alleles on chromosome 16q22 in colonic cancer". J. Pathol. 187 (5): 530–4. doi:10.1002/(SICI)1096-9896(199904)187:5<530::AID-PATH293>3.0.CO;2-C. PMID 10398117.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kashima T, Kawaguchi J, Takeshita S; et al. (1999). "Anomalous cadherin expression in osteosarcoma. Possible relationships to metastasis and morphogenesis". Am. J. Pathol. 155 (5): 1549–55. PMID 10550312.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lecanda F, Cheng SL, Shin CS; et al. (2000). "Differential regulation of cadherins by dexamethasone in human osteoblastic cells". J. Cell. Biochem. 77 (3): 499–506. PMID 10760957.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Braungart E, Hartman E, Bechler K; et al. (2002). "The intracellular domain of cadherin-11 is not required for the induction of cell aggregation, adhesion or gap-junction formation". Cell Commun. Adhes. 8 (1): 15–27. PMID 11775026.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Straub BK, Boda J, Kuhn C; et al. (2004). "A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells". J. Cell. Sci. 116 (Pt 24): 4985–95. doi:10.1242/jcs.00815. PMID 14625392.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Morimoto AM, Tan N, West K; et al. (2004). "Gene expression profiling of human colon xenograft tumors following treatment with SU11248, a multitargeted tyrosine kinase inhibitor". Oncogene. 23 (8): 1618–26. doi:10.1038/sj.onc.1207268. PMID 14985702.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Marchong MN, Chen D, Corson TW; et al. (2005). "Minimal 16q genomic loss implicates cadherin-11 in retinoblastoma". Mol. Cancer Res. 2 (9): 495–503. PMID 15383628.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Oliveira AM, Perez-Atayde AR, Inwards CY; et al. (2004). "USP6 and CDH11 oncogenes identify the neoplastic cell in primary aneurysmal bone cysts and are absent in so-called secondary aneurysmal bone cysts". Am. J. Pathol. 165 (5): 1773–80. PMID 15509545.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kiener HP, Brenner MB (2005). "Building the synovium: cadherin-11 mediates fibroblast-like synoviocyte cell-to-cell adhesion". Arthritis Res. Ther. 7 (2): 49–54. doi:10.1186/ar1495. PMID 15743489.
• Kiener HP, Lee DM, Agarwal SK, Brenner MB (2006). "Cadherin-11 induces rheumatoid arthritis fibroblast-like synoviocytes to form lining layers in vitro". Am. J. Pathol. 168 (5): 1486–99. PMID 16651616.CS1 maint: Multiple names: authors list (link)