CBFA2T3: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Protein CBFA2T3''' is a [[protein]] that in humans is encoded by the ''CBFA2T3'' [[gene]].<ref name="pmid9790752">{{cite journal | vauthors = Calabi F, Cilli V | title = CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family | journal = Genomics | volume = 52 | issue = 3 | pages = 332–41 | date = Dec 1998 | pmid = 9790752 | pmc = | doi = 10.1006/geno.1998.5429 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=863| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_CBFA2T3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2h7b.
| PDB = {{PDB2|2h7b}}
| Name = Core-binding factor, runt domain, alpha subunit 2; translocated to, 3
| HGNCid = 1537
| Symbol = CBFA2T3
| AltSymbols =; ETO2; MTG16; MTGR2; ZMYND4
| OMIM = 603870
| ECnumber = 
| Homologene = 74543
| MGIid = 1338013
| GeneAtlas_image1 = PBB_GE_CBFA2T3_208056_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 863
    | Hs_Ensembl = ENSG00000129993
    | Hs_RefseqProtein = NP_005178
    | Hs_RefseqmRNA = NM_005187
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 87468768
    | Hs_GenLoc_end = 87570902
    | Hs_Uniprot = 
    | Mm_EntrezGene = 12398
    | Mm_Ensembl = ENSMUSG00000006362
    | Mm_RefseqmRNA = NM_009824
    | Mm_RefseqProtein = NP_033954
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 125515553
    | Mm_GenLoc_end = 125585070
    | Mm_Uniprot = 
  }}
}}
'''Core-binding factor, runt domain, alpha subunit 2; translocated to, 3''', also known as '''CBFA2T3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=863| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The t(16;21)(q24;q22) translocation is a rare but recurrent chromosomal abnormality associated with therapy-related myeloid malignancies. The translocation produces a chimeric gene made up of the 5'-region of the [[AML1]] gene fused to the 3'-region of this gene. In addition, this gene is a putative breast tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene, and a [[brefeldin A]]-sensitive association of RII-alpha protein with one of the isoforms has been demonstrated in the [[Golgi apparatus]].<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The t(16;21)(q24;q22) translocation is a rare but recurrent chromosomal abnormality associated with therapy-related myeloid malignancies. The translocation produces a chimeric gene made up of the 5'-region of the AML1 gene fused to the 3'-region of this gene. In addition, this gene is a putative breast tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene, and a brefeldin A-sensitive association of RII-alpha protein with one of the isoforms has been demonstrated in the Golgi apparatus.<ref name="entrez">{{cite web | title = Entrez Gene: CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=863| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
CBFA2T3 has been shown to [[Protein-protein interaction|interact]] with:
==Further reading==
{{div col|colwidth=20em}}
* [[HDAC1]],<ref name = pmid12242670>{{cite journal | vauthors = Hoogeveen AT, Rossetti S, Stoyanova V, Schonkeren J, Fenaroli A, Schiaffonati L, van Unen L, Sacchi N | title = The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t (16; 21)-positive myeloid malignancies | journal = Oncogene | volume = 21 | issue = 43 | pages = 6703–12 | date = Sep 2002 | pmid = 12242670 | doi = 10.1038/sj.onc.1205882 }}</ref><ref name = pmid11533236>{{cite journal | vauthors = Amann JM, Nip J, Strom DK, Lutterbach B, Harada H, Lenny N, Downing JR, Meyers S, Hiebert SW | title = ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain | journal = Mol. Cell. Biol. | volume = 21 | issue = 19 | pages = 6470–83 | date = Oct 2001 | pmid = 11533236 | pmc = 99794 | doi =  10.1128/mcb.21.19.6470-6483.2001}}</ref>
* [[HDAC3]],<ref name = pmid12242670/><ref name = pmid11533236/>
* [[LDB1]],<ref name = pmid16407974/>
* [[PRKAR2A]],<ref name = pmid11823486>{{cite journal | vauthors = Schillace RV, Andrews SF, Liberty GA, Davey MP, Carr DW | title = Identification and characterization of myeloid translocation gene 16b as a novel a kinase anchoring protein in T lymphocytes | journal = J. Immunol. | volume = 168 | issue = 4 | pages = 1590–9 | date = Feb 2002 | pmid = 11823486 | doi =  10.4049/jimmunol.168.4.1590}}</ref>
* [[RUNX1T1]]<ref name = pmid12242670/><ref name = pmid14703694>{{cite journal | vauthors = Lindberg SR, Olsson A, Persson AM, Olsson I | title = Interactions between the leukaemia-associated ETO homologues of nuclear repressor proteins | journal = Eur. J. Haematol. | volume = 71 | issue = 6 | pages = 439–47 | date = Dec 2003 | pmid = 14703694 | doi =  10.1046/j.0902-4441.2003.00166.x}}</ref> and
* [[TAL1]],<ref name = pmid16407974/>  and
* [[TCF3]].<ref name = pmid16407974>{{cite journal | vauthors = Goardon N, Lambert JA, Rodriguez P, Nissaire P, Herblot S, Thibault P, Dumenil D, Strouboulis J, Romeo PH, Hoang T | title = ETO2 coordinates cellular proliferation and differentiation during erythropoiesis | journal = EMBO J. | volume = 25 | issue = 2 | pages = 357–66 | date = Jan 2006 | pmid = 16407974 | pmc = 1383517 | doi = 10.1038/sj.emboj.7600934 }}</ref>
{{Div col end}}
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Kitabayashi I, Ida K, Morohoshi F, Yokoyama A, Mitsuhashi N, Shimizu K, Nomura N, Hayashi Y, Ohki M | title = The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1. | journal = Mol. Cell. Biol. | volume = 18 | issue = 2 | pages = 846–58 | year = 1998 | pmid = 9447981 | pmc = 108796 | doi =  }}
| citations =
* {{cite journal | vauthors = Gamou T, Kitamura E, Hosoda F, Shimizu K, Shinohara K, Hayashi Y, Nagase T, Yokoyama Y, Ohki M | title = The partner gene of AML1 in t(16;21) myeloid malignancies is a novel member of the MTG8(ETO) family. | journal = Blood | volume = 91 | issue = 11 | pages = 4028–37 | year = 1998 | pmid = 9596646 | doi =  }}
*{{cite journal | author=Kitabayashi I, Ida K, Morohoshi F, ''et al.'' |title=The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1. |journal=Mol. Cell. Biol. |volume=18 |issue= 2 |pages= 846-58 |year= 1998 |pmid= 9447981 |doi=  }}
* {{cite journal | vauthors = Schillace RV, Andrews SF, Liberty GA, Davey MP, Carr DW | title = Identification and characterization of myeloid translocation gene 16b as a novel a kinase anchoring protein in T lymphocytes. | journal = J. Immunol. | volume = 168 | issue = 4 | pages = 1590–9 | year = 2002 | pmid = 11823486 | doi = 10.4049/jimmunol.168.4.1590 }}
*{{cite journal | author=Gamou T, Kitamura E, Hosoda F, ''et al.'' |title=The partner gene of AML1 in t(16;21) myeloid malignancies is a novel member of the MTG8(ETO) family. |journal=Blood |volume=91 |issue= 11 |pages= 4028-37 |year= 1998 |pmid= 9596646 |doi=  }}
* {{cite journal | vauthors = Kondoh K, Nakata Y, Furuta T, Hosoda F, Gamou T, Kurosawa Y, Kinoshita A, Ohki M, Tomita Y, Mori T | title = A pediatric case of secondary leukemia associated with t(16;21)(q24;q22) exhibiting the chimeric AML1-MTG16 gene. | journal = Leuk. Lymphoma | volume = 43 | issue = 2 | pages = 415–20 | year = 2003 | pmid = 11999578 | doi = 10.1080/10428190290006242 }}
*{{cite journal | author=Calabi F, Cilli V |title=CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family. |journal=Genomics |volume=52 |issue= 3 |pages= 332-41 |year= 1998 |pmid= 9790752 |doi= 10.1006/geno.1998.5429 }}
* {{cite journal | vauthors = Kochetkova M, McKenzie OL, Bais AJ, Martin JM, Secker GA, Seshadri R, Powell JA, Hinze SJ, Gardner AE, Spendlove HE, O'Callaghan NJ, Cleton-Jansen AM, Cornelisse C, Whitmore SA, Crawford J, Kremmidiotis G, Sutherland GR, Callen DF | title = CBFA2T3 (MTG16) is a putative breast tumor suppressor gene from the breast cancer loss of heterozygosity region at 16q24.3. | journal = Cancer Res. | volume = 62 | issue = 16 | pages = 4599–604 | year = 2002 | pmid = 12183414 | doi =  }}
*{{cite journal  | author=Schillace RV, Andrews SF, Liberty GA, ''et al.'' |title=Identification and characterization of myeloid translocation gene 16b as a novel a kinase anchoring protein in T lymphocytes. |journal=J. Immunol. |volume=168 |issue= 4 |pages= 1590-9 |year= 2002 |pmid= 11823486 |doi= }}
* {{cite journal | vauthors = Powell JA, Gardner AE, Bais AJ, Hinze SJ, Baker E, Whitmore S, Crawford J, Kochetkova M, Spendlove HE, Doggett NA, Sutherland GR, Callen DF, Kremmidiotis G | title = Sequencing, transcript identification, and quantitative gene expression profiling in the breast cancer loss of heterozygosity region 16q24.3 reveal three potential tumor-suppressor genes. | journal = Genomics | volume = 80 | issue = 3 | pages = 303–10 | year = 2003 | pmid = 12213200 | doi = 10.1006/geno.2002.6828 }}
*{{cite journal | author=Kondoh K, Nakata Y, Furuta T, ''et al.'' |title=A pediatric case of secondary leukemia associated with t(16;21)(q24;q22) exhibiting the chimeric AML1-MTG16 gene. |journal=Leuk. Lymphoma |volume=43 |issue= 2 |pages= 415-20 |year= 2003 |pmid= 11999578 |doi= }}
* {{cite journal | vauthors = Hoogeveen AT, Rossetti S, Stoyanova V, Schonkeren J, Fenaroli A, Schiaffonati L, van Unen L, Sacchi N | title = The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t (16; 21)-positive myeloid malignancies. | journal = Oncogene | volume = 21 | issue = 43 | pages = 6703–12 | year = 2002 | pmid = 12242670 | doi = 10.1038/sj.onc.1205882 }}
*{{cite journal | author=Kochetkova M, McKenzie OL, Bais AJ, ''et al.'' |title=CBFA2T3 (MTG16) is a putative breast tumor suppressor gene from the breast cancer loss of heterozygosity region at 16q24.3. |journal=Cancer Res. |volume=62 |issue= 16 |pages= 4599-604 |year= 2002 |pmid= 12183414 |doi=  }}
* {{cite journal | vauthors = Lindberg SR, Olsson A, Persson AM, Olsson I | title = Interactions between the leukaemia-associated ETO homologues of nuclear repressor proteins. | journal = Eur. J. Haematol. | volume = 71 | issue = 6 | pages = 439–47 | year = 2004 | pmid = 14703694 | doi = 10.1046/j.0902-4441.2003.00166.x }}
*{{cite journal | author=Powell JA, Gardner AE, Bais AJ, ''et al.'' |title=Sequencing, transcript identification, and quantitative gene expression profiling in the breast cancer loss of heterozygosity region 16q24.3 reveal three potential tumor-suppressor genes. |journal=Genomics |volume=80 |issue= 3 |pages= 303-10 |year= 2003 |pmid= 12213200 |doi= }}
* {{cite journal | vauthors = Ibañez V, Sharma A, Buonamici S, Verma A, Kalakonda S, Wang J, Kadkol S, Saunthararajah Y | title = AML1-ETO decreases ETO-2 (MTG16) interactions with nuclear receptor corepressor, an effect that impairs granulocyte differentiation. | journal = Cancer Res. | volume = 64 | issue = 13 | pages = 4547–54 | year = 2004 | pmid = 15231665 | doi = 10.1158/0008-5472.CAN-03-3689 }}
*{{cite journal | author=Hoogeveen AT, Rossetti S, Stoyanova V, ''et al.'' |title=The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t (16; 21)-positive myeloid malignancies. |journal=Oncogene |volume=21 |issue= 43 |pages= 6703-12 |year= 2002 |pmid= 12242670 |doi= 10.1038/sj.onc.1205882 }}
* {{cite journal | vauthors = Kumar R, Manning J, Spendlove HE, Kremmidiotis G, McKirdy R, Lee J, Millband DN, Cheney KM, Stampfer MR, Dwivedi PP, Morris HA, Callen DF | title = ZNF652, a novel zinc finger protein, interacts with the putative breast tumor suppressor CBFA2T3 to repress transcription. | journal = Mol. Cancer Res. | volume = 4 | issue = 9 | pages = 655–65 | year = 2006 | pmid = 16966434 | doi = 10.1158/1541-7786.MCR-05-0249 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Lindberg SR, Olsson A, Persson AM, Olsson I |title=Interactions between the leukaemia-associated ETO homologues of nuclear repressor proteins. |journal=Eur. J. Haematol. |volume=71 |issue= 6 |pages= 439-47 |year= 2004 |pmid= 14703694 |doi= }}
*{{cite journal | author=Ibañez V, Sharma A, Buonamici S, ''et al.'' |title=AML1-ETO decreases ETO-2 (MTG16) interactions with nuclear receptor corepressor, an effect that impairs granulocyte differentiation. |journal=Cancer Res. |volume=64 |issue= 13 |pages= 4547-54 |year= 2004 |pmid= 15231665 |doi= 10.1158/0008-5472.CAN-03-3689 }}
*{{cite journal | author=Kumar R, Manning J, Spendlove HE, ''et al.'' |title=ZNF652, a novel zinc finger protein, interacts with the putative breast tumor suppressor CBFA2T3 to repress transcription. |journal=Mol. Cancer Res. |volume=4 |issue= 9 |pages= 655-65 |year= 2006 |pmid= 16966434 |doi= 10.1158/1541-7786.MCR-05-0249 }}
}}
{{refend}}
{{refend}}


== External links ==
== External links ==
* {{MeshName|CBFA2T3+protein,+human}}
* {{MeshName|CBFA2T3+protein,+human}}
* {{UCSC gene info|CBFA2T3}}


{{PDB Gallery|geneid=863}}
{{Transcription factors|g4}}


{{protein-stub}}
{{NLM content}}
{{NLM content}}
{{Transcription factors}}
 
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
[[Category:Oncogenes]]
 
 
{{gene-16-stub}}

Latest revision as of 17:40, 5 December 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Protein CBFA2T3 is a protein that in humans is encoded by the CBFA2T3 gene.[1][2]

Function

The t(16;21)(q24;q22) translocation is a rare but recurrent chromosomal abnormality associated with therapy-related myeloid malignancies. The translocation produces a chimeric gene made up of the 5'-region of the AML1 gene fused to the 3'-region of this gene. In addition, this gene is a putative breast tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene, and a brefeldin A-sensitive association of RII-alpha protein with one of the isoforms has been demonstrated in the Golgi apparatus.[2]

Interactions

CBFA2T3 has been shown to interact with:

References

  1. ↑ Calabi F, Cilli V (Dec 1998). "CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family". Genomics. 52 (3): 332–41. doi:10.1006/geno.1998.5429. PMID 9790752.
  2. ↑ 2.0 2.1 "Entrez Gene: CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3".
  3. ↑ 3.0 3.1 3.2 Hoogeveen AT, Rossetti S, Stoyanova V, Schonkeren J, Fenaroli A, Schiaffonati L, van Unen L, Sacchi N (Sep 2002). "The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t (16; 21)-positive myeloid malignancies". Oncogene. 21 (43): 6703–12. doi:10.1038/sj.onc.1205882. PMID 12242670.
  4. ↑ 4.0 4.1 Amann JM, Nip J, Strom DK, Lutterbach B, Harada H, Lenny N, Downing JR, Meyers S, Hiebert SW (Oct 2001). "ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain". Mol. Cell. Biol. 21 (19): 6470–83. doi:10.1128/mcb.21.19.6470-6483.2001. PMC 99794. PMID 11533236.
  5. ↑ 5.0 5.1 5.2 Goardon N, Lambert JA, Rodriguez P, Nissaire P, Herblot S, Thibault P, Dumenil D, Strouboulis J, Romeo PH, Hoang T (Jan 2006). "ETO2 coordinates cellular proliferation and differentiation during erythropoiesis". EMBO J. 25 (2): 357–66. doi:10.1038/sj.emboj.7600934. PMC 1383517. PMID 16407974.
  6. ↑ Schillace RV, Andrews SF, Liberty GA, Davey MP, Carr DW (Feb 2002). "Identification and characterization of myeloid translocation gene 16b as a novel a kinase anchoring protein in T lymphocytes". J. Immunol. 168 (4): 1590–9. doi:10.4049/jimmunol.168.4.1590. PMID 11823486.
  7. ↑ Lindberg SR, Olsson A, Persson AM, Olsson I (Dec 2003). "Interactions between the leukaemia-associated ETO homologues of nuclear repressor proteins". Eur. J. Haematol. 71 (6): 439–47. doi:10.1046/j.0902-4441.2003.00166.x. PMID 14703694.

Further reading

  • Kitabayashi I, Ida K, Morohoshi F, Yokoyama A, Mitsuhashi N, Shimizu K, Nomura N, Hayashi Y, Ohki M (1998). "The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1". Mol. Cell. Biol. 18 (2): 846–58. PMC 108796. PMID 9447981.
  • Gamou T, Kitamura E, Hosoda F, Shimizu K, Shinohara K, Hayashi Y, Nagase T, Yokoyama Y, Ohki M (1998). "The partner gene of AML1 in t(16;21) myeloid malignancies is a novel member of the MTG8(ETO) family". Blood. 91 (11): 4028–37. PMID 9596646.
  • Schillace RV, Andrews SF, Liberty GA, Davey MP, Carr DW (2002). "Identification and characterization of myeloid translocation gene 16b as a novel a kinase anchoring protein in T lymphocytes". J. Immunol. 168 (4): 1590–9. doi:10.4049/jimmunol.168.4.1590. PMID 11823486.
  • Kondoh K, Nakata Y, Furuta T, Hosoda F, Gamou T, Kurosawa Y, Kinoshita A, Ohki M, Tomita Y, Mori T (2003). "A pediatric case of secondary leukemia associated with t(16;21)(q24;q22) exhibiting the chimeric AML1-MTG16 gene". Leuk. Lymphoma. 43 (2): 415–20. doi:10.1080/10428190290006242. PMID 11999578.
  • Kochetkova M, McKenzie OL, Bais AJ, Martin JM, Secker GA, Seshadri R, Powell JA, Hinze SJ, Gardner AE, Spendlove HE, O'Callaghan NJ, Cleton-Jansen AM, Cornelisse C, Whitmore SA, Crawford J, Kremmidiotis G, Sutherland GR, Callen DF (2002). "CBFA2T3 (MTG16) is a putative breast tumor suppressor gene from the breast cancer loss of heterozygosity region at 16q24.3". Cancer Res. 62 (16): 4599–604. PMID 12183414.
  • Powell JA, Gardner AE, Bais AJ, Hinze SJ, Baker E, Whitmore S, Crawford J, Kochetkova M, Spendlove HE, Doggett NA, Sutherland GR, Callen DF, Kremmidiotis G (2003). "Sequencing, transcript identification, and quantitative gene expression profiling in the breast cancer loss of heterozygosity region 16q24.3 reveal three potential tumor-suppressor genes". Genomics. 80 (3): 303–10. doi:10.1006/geno.2002.6828. PMID 12213200.
  • Hoogeveen AT, Rossetti S, Stoyanova V, Schonkeren J, Fenaroli A, Schiaffonati L, van Unen L, Sacchi N (2002). "The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t (16; 21)-positive myeloid malignancies". Oncogene. 21 (43): 6703–12. doi:10.1038/sj.onc.1205882. PMID 12242670.
  • Lindberg SR, Olsson A, Persson AM, Olsson I (2004). "Interactions between the leukaemia-associated ETO homologues of nuclear repressor proteins". Eur. J. Haematol. 71 (6): 439–47. doi:10.1046/j.0902-4441.2003.00166.x. PMID 14703694.
  • Ibañez V, Sharma A, Buonamici S, Verma A, Kalakonda S, Wang J, Kadkol S, Saunthararajah Y (2004). "AML1-ETO decreases ETO-2 (MTG16) interactions with nuclear receptor corepressor, an effect that impairs granulocyte differentiation". Cancer Res. 64 (13): 4547–54. doi:10.1158/0008-5472.CAN-03-3689. PMID 15231665.
  • Kumar R, Manning J, Spendlove HE, Kremmidiotis G, McKirdy R, Lee J, Millband DN, Cheney KM, Stampfer MR, Dwivedi PP, Morris HA, Callen DF (2006). "ZNF652, a novel zinc finger protein, interacts with the putative breast tumor suppressor CBFA2T3 to repress transcription". Mol. Cancer Res. 4 (9): 655–65. doi:10.1158/1541-7786.MCR-05-0249. PMID 16966434.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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