Biliary atresia natural history, complications and prognosis

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Biliary atresia Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Natural History, Complications and Prognosis

Complications

If unrecognised, the condition leads to liver failure but not (as one might think) to kernicterus. This is because the liver is still able to conjugate bilirubin, and conjugated bilirubin is unable to cross the blood-brain barrier.

Prognosis

Recent large volume studies from Davenport et al. (Ann Surg, 2008) show that age of the patient is not an absolute clinical factor affecting the prognosis. In the latter study, influence of age differs according to the disease etiology—i.e., whether isolated BA, BASM (BA with splenic malformation ), or CBA(cystic biliary atresia).

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