Baculoviral IAP repeat-containing protein 3

Baculoviral IAP repeat-containing 3
PDB rendering based on 2uvl.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2uvl​
Identifiers
Symbols	BIRC3 ; AIP1; API2; CIAP2; HAIP1; HIAP1; MALT2; MIHC; RNF49
External IDs	Template:OMIM5 Template:MGI HomoloGene: 899
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Baculoviral IAP repeat-containing 3, also known as BIRC3, is a human gene.

The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. The amino acid sequence predicts three baculovirus IAP repeat domains and a ring finger domain. Transcript variants encoding the same isoform have been identified.

Further reading

• Bertoni F, Cavalli F, Cotter FE, Zucca E (2003). "Genetic alterations underlying the pathogenesis of MALT lymphoma". Hematol. J. 3 (1): 10–3. doi:10.1038/sj/thj/6200146. PMID 11960389.CS1 maint: Multiple names: authors list (link)
• Rothe M, Pan MG, Henzel WJ; et al. (1996). "The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins". Cell. 83 (7): 1243–52. PMID 8548810.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liston P, Roy N, Tamai K; et al. (1996). "Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes". Nature. 379 (6563): 349–53. doi:10.1038/379349a0. PMID 8552191.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Uren AG, Pakusch M, Hawkins CJ; et al. (1996). "Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors". Proc. Natl. Acad. Sci. U.S.A. 93 (10): 4974–8. PMID 8643514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rajcan-Separovic E, Liston P, Lefebvre C, Korneluk RG (1997). "Assignment of human inhibitor of apoptosis protein (IAP) genes xiap, hiap-1, and hiap-2 to chromosomes Xq25 and 11q22-q23 by fluorescence in situ hybridization". Genomics. 37 (3): 404–6. doi:10.1006/geno.1996.0579. PMID 8938457.CS1 maint: Multiple names: authors list (link)
• Roy N, Deveraux QL, Takahashi R; et al. (1998). "The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases". EMBO J. 16 (23): 6914–25. doi:10.1093/emboj/16.23.6914. PMID 9384571.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Deveraux QL, Roy N, Stennicke HR; et al. (1998). "IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases". EMBO J. 17 (8): 2215–23. doi:10.1093/emboj/17.8.2215. PMID 9545235.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Young SS, Liston P, Xuan JY; et al. (1999). "Genomic organization and physical map of the human inhibitors of apoptosis: HIAP1 and HIAP2". Mamm. Genome. 10 (1): 44–8. PMID 9892732.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Horrevoets AJ, Fontijn RD, van Zonneveld AJ; et al. (1999). "Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes". Blood. 93 (10): 3418–31. PMID 10233894.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki H, Motegi M, Akagi T; et al. (1999). "API1-MALT1-MLT is involved in mucosa-associated lymphoid tissue lymphoma with t(11;18)(q21;q21)". Blood. 94 (9): 3270–1. PMID 10610122.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Huang H, Joazeiro CA, Bonfoco E; et al. (2000). "The inhibitor of apoptosis, cIAP2, functions as a ubiquitin-protein ligase and promotes in vitro monoubiquitination of caspases 3 and 7". J. Biol. Chem. 275 (35): 26661–4. doi:10.1074/jbc.C000199200. PMID 10862606.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Verhagen AM, Ekert PG, Pakusch M; et al. (2000). "Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins". Cell. 102 (1): 43–53. PMID 10929712.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Baens M, Steyls A, Dierlamm J; et al. (2001). "Structure of the MLT gene and molecular characterization of the genomic breakpoint junctions in the t(11;18)(q21;q21) of marginal zone B-cell lymphomas of MALT type". Genes Chromosomes Cancer. 29 (4): 281–91. PMID 11066071.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Werneburg BG, Zoog SJ, Dang TT; et al. (2001). "Molecular characterization of CD40 signaling intermediates". J. Biol. Chem. 276 (46): 43334–42. doi:10.1074/jbc.M104994200. PMID 11562359.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Imai Y, Nakayama H; et al. (2001). "A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death". Mol. Cell. 8 (3): 613–21. PMID 11583623.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li X, Yang Y, Ashwell JD (2002). "TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2". Nature. 416 (6878): 345–7. doi:10.1038/416345a. PMID 11907583.CS1 maint: Multiple names: authors list (link)
• Gordon GJ, Appasani K, Parcells JP; et al. (2002). "Inhibitor of apoptosis protein-1 promotes tumor cell survival in mesothelioma". Carcinogenesis. 23 (6): 1017–24. PMID 12082024.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sharief MK, Noori MA, Zoukos Y (2002). "Reduced expression of the inhibitor of apoptosis proteins in T cells from patients with multiple sclerosis following interferon-beta therapy". J. Neuroimmunol. 129 (1–2): 224–31. PMID 12161039.CS1 maint: Multiple names: authors list (link)
• Ekedahl J, Joseph B, Grigoriev MY; et al. (2002). "Expression of inhibitor of apoptosis proteins in small- and non-small-cell lung carcinoma cells". Exp. Cell Res. 279 (2): 277–90. PMID 12243753.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)