Atopic dermatitis differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].

OR

[Disease name] must be differentiated from [[differential dx1], [differential dx2], and [differential dx3].

Differentiating [Disease name] from other Diseases

[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].

OR

[Disease name] must be differentiated from [differential dx1], [differential dx2], and [differential dx3].

OR

As [disease name] manifests in a variety of clinical forms, differentiation must be established in accordance with the particular subtype. [Subtype name 1] must be differentiated from other diseases that cause [clinical feature 1], such as [differential dx1] and [differential dx2]. In contrast, [subtype name 2] must be differentiated from other diseases that cause [clinical feature 2], such as [differential dx3] and [differential dx4].

Differentiating [disease name] from other diseases on the basis of [symptom 1], [symptom 2], and [symptom 3]

On the basis [symptom 1], [symptom 2], and [symptom 3], [disease name] must be differentiated from [disease 1], [disease 2], [disease 3], [disease 4], [disease 5], and [disease 6].

  • Chronic inflammatory skin diseases
    • Contact (allergic, irritant)
    • Seborrhoeic dermatitis
      • onset during the 1st days or weeks of life, absence of pruritus, and presence of greasy scaling on a yellow-red base
      • Involvement of the top of the scalp (cradle cap), axilla, and diaper area makes it more likely the patient has seborrheic dermatitis, vs excoriated dermatitis involving the extensor surfaces, face, and trunk favour AE.
    • Psoriasis
    • Lichen simplex chronicus
  • Infectious agents
    • Candida
    • Dermatophytes
    • Herpes simplex
    • Staphylococcus aureus
    • Sarcoptes scabiei
      • highly pruritic, erythematous papular lesions. In most cases, the typical burrows can be found on the flexor wrists, finger webs and genitalia. Similar symptoms in other family members
    • HIV-associated dermatitis
  • Immunologic disorders
    • Dermatitis herpetiformis
    • Pemphigus foliaceus
    • Graft-versus-host disease
    • Dermatomyositis
  • Malignant Diseases
    • Cutaneous T-cell lymphoma (mycosis fungoides, S´ezary syndrome)
    • Histiocytosis X (Letterer-Siwe disease)
  • Congenital disorders
    • Netherton’s syndrome
    • Dubowitz syndrome
    • Erythrokeratodermia variabilis
  • Immunodeficiencies
    • Wiskott-Aldrich syndrome (immunodeficiency with thrombocytopenia and eczema)
    • Thymic hypoplasia (DiGeorge syndrome)
    • Hyper-IgE syndrome
    • Severe combined immunodeficiency (SCID)
    • Ataxia teleangiectasia
  • Metabolic Diseases
    • Phenylketonuria
    • Tyrosinemia
    • Histidinemia
    • Zinc deficiency
    • Pyridoxine (vitamin B6) and niacin deficiency
    • Multiple carboxylase deficiency
  • Nonallergic reaction to medication
    • Infliximab
Diseases Clinical manifestations Para-clinical findings Gold standard Additional findings
Symptoms Physical examination
Lab Findings Imaging Histopathology
Symptom 1 Symptom 2 Symptom 3 Physical exam 1 Physical exam 2 Physical exam 3 Lab 1 Lab 2 Lab 3 Imaging 1 Imaging 2 Imaging 3
Allergic contact dermatitis
Irritant contact dermatitis
Seborrheic dermatitis
Psoriasis
Scabies
Wiskott-Aldrich syndrome
Autosomal dominant hyperimmunoglobulin E syndrome
Zinc deficiency
Ichthyosis vulgaris
Mycosis fungoides
Nummular Dermatitis
Plaque Psoriasis
  • Chronic inflammatory skin diseases
    • Contact (allergic, irritant)
    • Seborrhoeic dermatitis
      • onset during the 1st days or weeks of life, absence of pruritus, and presence of greasy scaling on a yellow-red base
      • Involvement of the top of the scalp (cradle cap), axilla, and diaper area makes it more likely the patient has seborrheic dermatitis, vs excoriated dermatitis involving the extensor surfaces, face, and trunk favour AE.
    • Psoriasis
    • Lichen simplex chronicus
  • Infectious agents
    • Candida
    • Dermatophytes
    • Herpes simplex
    • Staphylococcus aureus
    • Sarcoptes scabiei
      • highly pruritic, erythematous papular lesions. In most cases, the typical burrows can be found on the flexor wrists, finger webs and genitalia. Similar symptoms in other family members
    • HIV-associated dermatitis
  • Immunologic disorders
    • Dermatitis herpetiformis
    • Pemphigus foliaceus
    • Graft-versus-host disease
    • Dermatomyositis
  • Malignant Diseases
    • Cutaneous T-cell lymphoma (mycosis fungoides, S´ezary syndrome)
    • Histiocytosis X (Letterer-Siwe disease)
  • Congenital disorders
    • Netherton’s syndrome
    • Dubowitz syndrome
    • Erythrokeratodermia variabilis
  • Immunodeficiencies
    • Wiskott-Aldrich syndrome (immunodeficiency with thrombocytopenia and eczema)
    • Thymic hypoplasia (DiGeorge syndrome)
    • Hyper-IgE syndrome
    • Severe combined immunodeficiency (SCID)
    • Ataxia teleangiectasia
  • Metabolic Diseases
    • Phenylketonuria
    • Tyrosinemia
    • Histidinemia
    • Zinc deficiency
    • Pyridoxine (vitamin B6) and niacin deficiency
    • Multiple carboxylase deficiency
  • Nonallergic reaction to medication
    • Infliximab

References


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