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==Classification==
==Classification==
Asplenia may be classified into two groups based on its cause: [[Congenital]]: Isolated asplenia, heterotaxy syndrome, and [[Acquired]]: Functional asplenia.


==Pathophysiology==
==Pathophysiology==

Revision as of 12:10, 19 July 2021

Asplenia Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Anum Dilip, M.B.B.S[2]

Overview

Hippocrates made the first description of the gross anatomy of the spleen in 421 BC. In 1899, Chauffard described that increased splenic activity is linked to hemolysis, and in 1910, Sutherland and Brughard performed the first therapeutic splenectomy in a patient with hereditary spherocytosis. In 1919, Morris and Bullock provided initial experimental evidence of the protective role of the spleen against infections. Asplenia may be classified into two groups based on its cause: Congenital: Isolated asplenia, heterotaxy syndrome, and Acquired: Functional asplenia.

Historical Perspective

Hippocrates made the first description of the gross anatomy of the spleen in 421 BC. In 1899, Chauffard described that increased splenic activity is linked to hemolysis, and in 1910, Sutherland and Brughard performed the first therapeutic splenectomy in a patient with hereditary spherocytosis. In 1919, Morris and Bullock provided initial experimental evidence of the protective role of the spleen against infections.

Classification

Asplenia may be classified into two groups based on its cause: Congenital: Isolated asplenia, heterotaxy syndrome, and Acquired: Functional asplenia.

Pathophysiology

Causes

Differentiating Asplenia overview from Other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications, and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

Echocardiography and Ultrasound

CT scan

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Interventions

Surgery

Primary Prevention

Secondary Prevention

References

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