Anti-β2 glycoprotein I antibody: Difference between revisions

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{{CMG}}; '''Associate Editor-In-Chief:''' {{MJ}}
{{CMG}}; '''Associate Editor-In-Chief:''' {{MJ}}


== Anti-β2 glycoprotein I antibody ==
Anti-β2 glycoprotein I antibodies along with [[anti-cardiolipin antibodies]] and lupus anticoagulant are involved in thrombosis and sclerosis in the [[antiphospholipid syndrome]] and autoimmune form of [[deep vein thrombosis]]. These antibodies interfere with [[factor X]] of [[Coagulation|coagulation cascade]] factors.  
Anti-β2 glycoprotein I antibodies along with [[anti-cardiolipin antibodies]] and lupus anticoagulant are involved in thrombosis and sclerosis in the [[antiphospholipid syndrome]] and autoimmune form of [[deep vein thrombosis]]. These antibodies interfere with [[factor X]] of [[Coagulation|coagulation cascade]] factors.  
The [[HLA-DR4|HLA-DR4-DQ3]], [[HLA-DR4|DR4-DQ8]], and [[HLA-DR7]] are found to be involved in the pathogenesis of these antibodies.<ref name="pmid137261">{{cite journal |vauthors=Kouttab NM, Fowler AK, Strickland JE, Hellman A |title=Suprresion of in vitro lymphocyte stimulation in mice by uterine and placental extracts |journal=J. Immunol. |volume=117 |issue=5 Pt 1 |pages=1644–50 |date=November 1976 |pmid=137261 |doi= |url=}}</ref><ref name="pmid8485053">{{cite journal |vauthors=Galli M, Bevers EM, Comfurius P, Barbui T, Zwaal RF |title=Effect of antiphospholipid antibodies on procoagulant activity of activated platelets and platelet-derived microvesicles |journal=Br. J. Haematol. |volume=83 |issue=3 |pages=466–72 |date=March 1993 |pmid=8485053 |doi= |url=}}</ref><ref name="pmid8814057">{{cite journal |vauthors=Tsutsumi A, Matsuura E, Ichikawa K, Fujisaku A, Mukai M, Kobayashi S, Koike T |title=Antibodies to beta 2-glycoprotein I and clinical manifestations in patients with systemic lupus erythematosus |journal=Arthritis Rheum. |volume=39 |issue=9 |pages=1466–74 |date=September 1996 |pmid=8814057 |doi= |url=}}</ref><ref name="pmid8236146">{{cite journal |vauthors=Shi W, Chong BH, Hogg PJ, Chesterman CN |title=Anticardiolipin antibodies block the inhibition by beta 2-glycoprotein I of the factor Xa generating activity of platelets |journal=Thromb. Haemost. |volume=70 |issue=2 |pages=342–5 |date=August 1993 |pmid=8236146 |doi= |url=}}</ref><ref name="pmid12974796">{{cite journal |vauthors=Klitz W, Maiers M, Spellman S, Baxter-Lowe LA, Schmeckpeper B, Williams TM, Fernandez-Viña M |title=New HLA haplotype frequency reference standards: high-resolution and large sample typing of HLA DR-DQ haplotypes in a sample of European Americans |journal=Tissue Antigens |volume=62 |issue=4 |pages=296–307 |date=October 2003 |pmid=12974796 |doi= |url=}}</ref>
The [[HLA-DR4|HLA-DR4-DQ3]], [[HLA-DR4|DR4-DQ8]], and [[HLA-DR7]] are found to be involved in the pathogenesis of these antibodies.<ref name="pmid137261">{{cite journal |vauthors=Kouttab NM, Fowler AK, Strickland JE, Hellman A |title=Suprresion of in vitro lymphocyte stimulation in mice by uterine and placental extracts |journal=J. Immunol. |volume=117 |issue=5 Pt 1 |pages=1644–50 |date=November 1976 |pmid=137261 |doi= |url=}}</ref><ref name="pmid8485053">{{cite journal |vauthors=Galli M, Bevers EM, Comfurius P, Barbui T, Zwaal RF |title=Effect of antiphospholipid antibodies on procoagulant activity of activated platelets and platelet-derived microvesicles |journal=Br. J. Haematol. |volume=83 |issue=3 |pages=466–72 |date=March 1993 |pmid=8485053 |doi= |url=}}</ref><ref name="pmid8814057">{{cite journal |vauthors=Tsutsumi A, Matsuura E, Ichikawa K, Fujisaku A, Mukai M, Kobayashi S, Koike T |title=Antibodies to beta 2-glycoprotein I and clinical manifestations in patients with systemic lupus erythematosus |journal=Arthritis Rheum. |volume=39 |issue=9 |pages=1466–74 |date=September 1996 |pmid=8814057 |doi= |url=}}</ref><ref name="pmid8236146">{{cite journal |vauthors=Shi W, Chong BH, Hogg PJ, Chesterman CN |title=Anticardiolipin antibodies block the inhibition by beta 2-glycoprotein I of the factor Xa generating activity of platelets |journal=Thromb. Haemost. |volume=70 |issue=2 |pages=342–5 |date=August 1993 |pmid=8236146 |doi= |url=}}</ref><ref name="pmid12974796">{{cite journal |vauthors=Klitz W, Maiers M, Spellman S, Baxter-Lowe LA, Schmeckpeper B, Williams TM, Fernandez-Viña M |title=New HLA haplotype frequency reference standards: high-resolution and large sample typing of HLA DR-DQ haplotypes in a sample of European Americans |journal=Tissue Antigens |volume=62 |issue=4 |pages=296–307 |date=October 2003 |pmid=12974796 |doi= |url=}}</ref>

Latest revision as of 20:11, 17 May 2018

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Mehrian Jafarizade, M.D [2]

Anti-β2 glycoprotein I antibody

Anti-β2 glycoprotein I antibodies along with anti-cardiolipin antibodies and lupus anticoagulant are involved in thrombosis and sclerosis in the antiphospholipid syndrome and autoimmune form of deep vein thrombosis. These antibodies interfere with factor X of coagulation cascade factors. The HLA-DR4-DQ3, DR4-DQ8, and HLA-DR7 are found to be involved in the pathogenesis of these antibodies.[1][2][3][4][5]

References

  1. ↑ Kouttab NM, Fowler AK, Strickland JE, Hellman A (November 1976). "Suprresion of in vitro lymphocyte stimulation in mice by uterine and placental extracts". J. Immunol. 117 (5 Pt 1): 1644–50. PMID 137261.
  2. ↑ Galli M, Bevers EM, Comfurius P, Barbui T, Zwaal RF (March 1993). "Effect of antiphospholipid antibodies on procoagulant activity of activated platelets and platelet-derived microvesicles". Br. J. Haematol. 83 (3): 466–72. PMID 8485053.
  3. ↑ Tsutsumi A, Matsuura E, Ichikawa K, Fujisaku A, Mukai M, Kobayashi S, Koike T (September 1996). "Antibodies to beta 2-glycoprotein I and clinical manifestations in patients with systemic lupus erythematosus". Arthritis Rheum. 39 (9): 1466–74. PMID 8814057.
  4. ↑ Shi W, Chong BH, Hogg PJ, Chesterman CN (August 1993). "Anticardiolipin antibodies block the inhibition by beta 2-glycoprotein I of the factor Xa generating activity of platelets". Thromb. Haemost. 70 (2): 342–5. PMID 8236146.
  5. ↑ Klitz W, Maiers M, Spellman S, Baxter-Lowe LA, Schmeckpeper B, Williams TM, Fernandez-Viña M (October 2003). "New HLA haplotype frequency reference standards: high-resolution and large sample typing of HLA DR-DQ haplotypes in a sample of European Americans". Tissue Antigens. 62 (4): 296–307. PMID 12974796.

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