Anaplastic large cell lymphoma differential diagnosis: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Anaplastic large cell lymphoma}} | {{Anaplastic large cell lymphoma}} | ||
{{CMG}} | {{CMG}}; {{AE}} {{AS}} | ||
==Overview== | |||
Anaplastic large cell lymphoma must be differentiated from other diseases such as [[metastatic]] [[carcinoma]], [[B cell lymphoma]], primary cutaneous T-cell lymphoma, rhabdomyosarcoma, peripheral T-cell lymphoma-not otherwise specified, classical Hodgkin's lymphoma, and diffuse large B cell lymphoma. | |||
==Differential diagnosis== | ==Differential diagnosis== | ||
*As the appearance of the hallmark cells, pattern of growth (nesting within lymph nodes) and positivity for EMA may mimic [[metastatic]] [[carcinoma]], it is important to include markers for [[cytokeratin]] in any diagnostic panel (these will be negative in the case of anaplastic lymphoma). | * As the appearance of the hallmark cells, pattern of growth (nesting within lymph nodes) and positivity for EMA may mimic [[metastatic]] [[carcinoma]], it is important to include markers for [[cytokeratin]] in any diagnostic panel (these will be negative in the case of anaplastic lymphoma). | ||
*Other mimics include CD30 positive B-cell lymphomas with anaplastic cells (including Hodgkin lymphomas). These are identified by their positivity for markers of B-cell lineage and frequent presence of markers of EBV. | * Other mimics include CD30 positive B-cell lymphomas with anaplastic cells (including Hodgkin lymphomas). These are identified by their positivity for markers of B-cell lineage and frequent presence of markers of EBV. | ||
*Primary cutaneous T-cell lymphomas may also be positive for CD30; these are excluded by their anatomic distribution. ALK positivity may also be seen in some large cell B-cell lymphomas and occasionally in [[rhabdomyosarcoma]]s. | * Primary cutaneous T-cell lymphomas may also be positive for CD30; these are excluded by their anatomic distribution. | ||
* ALK positivity may also be seen in some large cell B-cell lymphomas and occasionally in [[rhabdomyosarcoma]]s. | |||
* | * Peripheral T-cell lymphoma-not otherwise specified (PTCL-NOS)<ref name="pmid22789917">{{cite journal| author=Ferreri AJ, Govi S, Pileri SA, Savage KJ| title=Anaplastic large cell lymphoma, ALK-negative. | journal=Crit Rev Oncol Hematol | year= 2013 | volume= 85 | issue= 2 | pages= 206-15 | pmid=22789917 | doi=10.1016/j.critrevonc.2012.06.004 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22789917 }} </ref><ref name="ALK+/ALK-">{{cite web|url=http://www.bloodjournal.org/content/111/12/5496?sso-checked=true|title=ALK- anaplastic large-cell lymphoma is clinically and immunophenotypically different from both ALK+ ALCL and peripheral T-cell lymphoma, not otherwise specified: report from the International Peripheral T-Cell Lymphoma Project}}</ref> | ||
*Classical [[Hodgkin's lymphoma]]<ref name="pmid22789917">{{cite journal| author=Ferreri AJ, Govi S, Pileri SA, Savage KJ| title=Anaplastic large cell lymphoma, ALK-negative. | journal=Crit Rev Oncol Hematol | year= 2013 | volume= 85 | issue= 2 | pages= 206-15 | pmid=22789917 | doi=10.1016/j.critrevonc.2012.06.004 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22789917 }} </ref> | |||
*Diffuse large B-cell lymphoma | |||
*[[Hodgkin lymphoma]] | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
[[Category:Hematology]] | [[Category:Hematology]] | ||
[[Category:Types of cancer]] | [[Category:Types of cancer]] | ||
Revision as of 14:01, 13 October 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]
Overview
Anaplastic large cell lymphoma must be differentiated from other diseases such as metastatic carcinoma, B cell lymphoma, primary cutaneous T-cell lymphoma, rhabdomyosarcoma, peripheral T-cell lymphoma-not otherwise specified, classical Hodgkin's lymphoma, and diffuse large B cell lymphoma.
Differential diagnosis
- As the appearance of the hallmark cells, pattern of growth (nesting within lymph nodes) and positivity for EMA may mimic metastatic carcinoma, it is important to include markers for cytokeratin in any diagnostic panel (these will be negative in the case of anaplastic lymphoma).
- Other mimics include CD30 positive B-cell lymphomas with anaplastic cells (including Hodgkin lymphomas). These are identified by their positivity for markers of B-cell lineage and frequent presence of markers of EBV.
- Primary cutaneous T-cell lymphomas may also be positive for CD30; these are excluded by their anatomic distribution.
- ALK positivity may also be seen in some large cell B-cell lymphomas and occasionally in rhabdomyosarcomas.
- Peripheral T-cell lymphoma-not otherwise specified (PTCL-NOS)[1][2]
- Classical Hodgkin's lymphoma[1]
- Diffuse large B-cell lymphoma
References
- ↑ 1.0 1.1 Ferreri AJ, Govi S, Pileri SA, Savage KJ (2013). "Anaplastic large cell lymphoma, ALK-negative". Crit Rev Oncol Hematol. 85 (2): 206–15. doi:10.1016/j.critrevonc.2012.06.004. PMID 22789917.
- ↑ "ALK- anaplastic large-cell lymphoma is clinically and immunophenotypically different from both ALK+ ALCL and peripheral T-cell lymphoma, not otherwise specified: report from the International Peripheral T-Cell Lymphoma Project".