Amyloidosis history and symptoms: Difference between revisions

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{{Amyloidosis}}
{{Amyloidosis}}
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== Overview==
== Overview==
Symptoms depend on the organs affected by the deposits.  These organs can include the tongue, intestines, skeletal and smooth muscles, nerves, skin, ligaments, heart, liver, spleen, and kidneys.
Common [[symptoms]] of amyloidosis include [[abdominal pain]], [[edema]] and [[enlarged tongue]]. Less common [[symptoms]] of amyloidosis include [[Gastrointestinal bleeding|gastrointestinal bleeding, gross]] [[hematuria]], [[hoarseness]] and [[paresthesias]].  
==History==
 
==Common Symptoms==
==History and Symptoms==
Symptoms depend on the organs affected by the deposits.  These organs can include the tongue, intestines, skeletal and smooth muscles, nerves, skin, ligaments, heart, liver, spleen, and kidneys.
 
=== History ===
Patients with amyloidosis may have a positive history of:<ref name="pmid24497558">{{cite journal |vauthors=Mahmood S, Palladini G, Sanchorawala V, Wechalekar A |title=Update on treatment of light chain amyloidosis |journal=Haematologica |volume=99 |issue=2 |pages=209–21 |date=February 2014 |pmid=24497558 |pmc=3912950 |doi=10.3324/haematol.2013.087619 |url=}}</ref>
*[[Dyspnea]]
*[[Lethargy]]
*[[Weight loss]]
*[[Chest discomfort]]
*[[Fevers]] or [[chills]]
*[[Night sweats]]
 
===Common Symptoms===
Common [[symptoms]] of primary amyloidosis include:<ref name="pmid26161016">{{cite journal |vauthors=Lim AY, Lee JH, Jung KS, Gwag HB, Kim DH, Kim SJ, Lee GY, Kim JS, Kim HJ, Lee SY, Lee JE, Jeon ES, Kim K |title=Clinical features and outcomes of systemic amyloidosis with gastrointestinal involvement: a single-center experience |journal=Korean J. Intern. Med. |volume=30 |issue=4 |pages=496–505 |date=July 2015 |pmid=26161016 |pmc=4497337 |doi=10.3904/kjim.2015.30.4.496 |url=}}</ref><ref name="pmid23227278">{{cite journal |vauthors=Baker KR, Rice L |title=The amyloidoses: clinical features, diagnosis and treatment |journal=Methodist Debakey Cardiovasc J |volume=8 |issue=3 |pages=3–7 |date=2012 |pmid=23227278 |pmc=3487569 |doi= |url=}}</ref>


Symptoms include:
* Palpitations
* [[Hemoptysis]]
* [[Cough]]
* [[Lightheadedness]]
* [[Fatigue]]
* [[Fatigue]]
* [[Numbness]] of hands and feet
* [[Shortness of breath]]
* Skin changes
* Swallowing problems
* Swelling in the arms and legs
* Weak hand grip
* [[Weight loss]]
* [[Weight loss]]
* [[Edema]]
*[[Abdominal pain]]
*[[Enlarged tongue]]
===Less Common Symptoms===
Less common [[symptoms]] of amyloidosis include:<ref name="pmid10228037">{{cite journal |vauthors=Hamidi Asl K, Liepnieks JJ, Nakamura M, Benson MD |title=Organ-specific (localized) synthesis of Ig light chain amyloid |journal=J. Immunol. |volume=162 |issue=9 |pages=5556–60 |date=May 1999 |pmid=10228037 |doi= |url=}}</ref>


==Less Common Symptoms==
*[[Hoarseness]]
* [[Decreased urine output]]
*[[Gastrointestinal bleeding]]
* [[Diarrhea]]
*[[Diarrhea]]
* [[Hoarseness]] or changing voice
*Paresthesias
* [[Joint pain]]
*Gross [[hematuria]]
* [[Weakness]]
*Irritative [[urinary symptoms]]


== References ==
== References ==
{{reflist|2}}
{{reflist|2}}


{{WH}}
{{WS}}
[[Category:Disease]]
[[Category:Disease]]
[[Category:Rheumatology]]
[[Category:Rheumatology]]
[[Category:Cardiology]]
[[Category:Cardiology]]
[[Category:Mature chapter]]
[[Category:Metabolic disorders]]
[[Category:Inborn errors of metabolism]]
[[Category:Endocrinology]]
[[Category:Endocrinology]]
{{WH}}
{{WS}}

Latest revision as of 15:32, 30 October 2019

Amyloidosis Microchapters

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Overview

Historical Perspective

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Primary amyloidosis
Secondary amyloidosis
Familial amyloidosis
Wild-type (senile) amyloidosis
Cardiac amyloidosis
Beta-2 microglobulin related amyloidosis
Gelsolin related amyloidosis
Lysozyme amyloid related amyloidosis
Leucocyte cell-derived chemotaxin 2 related amyloidosis
Fibrinogen A alpha-chain associated amyloidosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]; Associate Editor(s)-in-Chief: Shaghayegh Habibi, M.D.[3]

Overview

Common symptoms of amyloidosis include abdominal pain, edema and enlarged tongue. Less common symptoms of amyloidosis include gastrointestinal bleeding, gross hematuria, hoarseness and paresthesias.

History and Symptoms

History

Patients with amyloidosis may have a positive history of:[1]

Common Symptoms

Common symptoms of primary amyloidosis include:[2][3]

Less Common Symptoms

Less common symptoms of amyloidosis include:[4]

References

  1. Mahmood S, Palladini G, Sanchorawala V, Wechalekar A (February 2014). "Update on treatment of light chain amyloidosis". Haematologica. 99 (2): 209–21. doi:10.3324/haematol.2013.087619. PMC 3912950. PMID 24497558.
  2. Lim AY, Lee JH, Jung KS, Gwag HB, Kim DH, Kim SJ, Lee GY, Kim JS, Kim HJ, Lee SY, Lee JE, Jeon ES, Kim K (July 2015). "Clinical features and outcomes of systemic amyloidosis with gastrointestinal involvement: a single-center experience". Korean J. Intern. Med. 30 (4): 496–505. doi:10.3904/kjim.2015.30.4.496. PMC 4497337. PMID 26161016.
  3. Baker KR, Rice L (2012). "The amyloidoses: clinical features, diagnosis and treatment". Methodist Debakey Cardiovasc J. 8 (3): 3–7. PMC 3487569. PMID 23227278.
  4. Hamidi Asl K, Liepnieks JJ, Nakamura M, Benson MD (May 1999). "Organ-specific (localized) synthesis of Ig light chain amyloid". J. Immunol. 162 (9): 5556–60. PMID 10228037.

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