ATP2B4

ATPase, Ca++ transporting, plasma membrane 4
Identifiers
Symbols	ATP2B4 ; ATP2B2; DKFZp686G08106; DKFZp686M088; MXRA1; PMCA4
External IDs	Template:OMIM5 Template:MGI HomoloGene: 48034
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

ATPase, Ca++ transporting, plasma membrane 4, also known as ATP2B4, is a human gene.

The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified.

Further reading

• Møller JV, Juul B, le Maire M (1996). "Structural organization, ion transport, and energy transduction of P-type ATPases". Biochim. Biophys. Acta. 1286 (1): 1–51. PMID 8634322.CS1 maint: Multiple names: authors list (link)
• Strehler EE, Zacharias DA (2001). "Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps". Physiol. Rev. 81 (1): 21–50. PMID 11152753.
• Strehler EE, Treiman M (2004). "Calcium pumps of plasma membrane and cell interior". Curr. Mol. Med. 4 (3): 323–35. PMID 15101689.
• Heim R, Hug M, Iwata T; et al. (1992). "Microdiversity of human-plasma-membrane calcium-pump isoform 2 generated by alternative RNA splicing in the N-terminal coding region". Eur. J. Biochem. 205 (1): 333–40. PMID 1313367.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brandt P, Neve RL, Kammesheidt A; et al. (1992). "Analysis of the tissue-specific distribution of mRNAs encoding the plasma membrane calcium-pumping ATPases and characterization of an alternately spliced form of PMCA4 at the cDNA and genomic levels". J. Biol. Chem. 267 (7): 4376–85. PMID 1531651.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Olson S, Wang MG, Carafoli E; et al. (1991). "Localization of two genes encoding plasma membrane Ca2(+)-transporting ATPases to human chromosomes 1q25-32 and 12q21-23". Genomics. 9 (4): 629–41. PMID 1674727.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strehler EE, James P, Fischer R; et al. (1990). "Peptide sequence analysis and molecular cloning reveal two calcium pump isoforms in the human erythrocyte membrane". J. Biol. Chem. 265 (5): 2835–42. PMID 2137451.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• James P, Maeda M, Fischer R; et al. (1988). "Identification and primary structure of a calmodulin binding domain of the Ca2+ pump of human erythrocytes". J. Biol. Chem. 263 (6): 2905–10. PMID 2963820.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brandt P, Zurini M, Neve RL; et al. (1988). "A C-terminal, calmodulin-like regulatory domain from the plasma membrane Ca2+-pumping ATPase". Proc. Natl. Acad. Sci. U.S.A. 85 (9): 2914–8. PMID 2966397.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Howard A, Barley NF, Legon S, Walters JR (1994). "Plasma-membrane calcium-pump isoforms in human and rat liver". Biochem. J. 303 ( Pt 1): 275–9. PMID 7945253.CS1 maint: Multiple names: authors list (link)
• Stauffer TP, Hilfiker H, Carafoli E, Strehler EE (1995). "Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes". J. Biol. Chem. 269 (50): 32022. PMID 7989379.CS1 maint: Multiple names: authors list (link)
• Stauffer TP, Hilfiker H, Carafoli E, Strehler EE (1994). "Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes". J. Biol. Chem. 268 (34): 25993–6003. PMID 8245032.CS1 maint: Multiple names: authors list (link)
• Váradi A, Molnár E, Ashcroft SJ (1996). "A unique combination of plasma membrane Ca2+-ATPase isoforms is expressed in islets of Langerhans and pancreatic beta-cell lines". Biochem. J. 314 ( Pt 2): 663–9. PMID 8670083.CS1 maint: Multiple names: authors list (link)
• Santiago-García J, Mas-Oliva J, Saavedra D, Zarain-Herzberg A (1996). "Analysis of mRNA expression and cloning of a novel plasma membrane Ca(2+)-ATPase splice variant in human heart". Mol. Cell. Biochem. 155 (2): 173–82. PMID 8700162.CS1 maint: Multiple names: authors list (link)
• Zacharias DA, DeMarco SJ, Strehler EE (1997). "mRNA expression of the four isoforms of the human plasma membrane Ca(2+)-ATPase in the human hippocampus". Brain Res. Mol. Brain Res. 45 (1): 173–6. PMID 9105688.CS1 maint: Multiple names: authors list (link)
• Dean WL, Chen D, Brandt PC, Vanaman TC (1997). "Regulation of platelet plasma membrane Ca2+-ATPase by cAMP-dependent and tyrosine phosphorylation". J. Biol. Chem. 272 (24): 15113–9. PMID 9182531.CS1 maint: Multiple names: authors list (link)
• Kim E, DeMarco SJ, Marfatia SM; et al. (1998). "Plasma membrane Ca2+ ATPase isoform 4b binds to membrane-associated guanylate kinase (MAGUK) proteins via their PDZ (PSD-95/Dlg/ZO-1) domains". J. Biol. Chem. 273 (3): 1591–5. PMID 9430700.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Guerini D, García-Martin E, Gerber A; et al. (1999). "The expression of plasma membrane Ca2+ pump isoforms in cerebellar granule neurons is modulated by Ca2+". J. Biol. Chem. 274 (3): 1667–76. PMID 9880546.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rosado JA, Sage SO (2000). "Regulation of plasma membrane Ca2+-ATPase by small GTPases and phosphoinositides in human platelets". J. Biol. Chem. 275 (26): 19529–35. doi:10.1074/jbc.M001319200. PMID 10748016.