APOA4

Apolipoprotein A-IV
Identifiers
Symbols	APOA4 ; MGC142154; MGC142156
External IDs	Template:OMIM5 Template:MGI HomoloGene: 47927
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Apolipoprotein A-IV, also known as APOA4, is a human gene.

Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro.

Further reading

• von Eckardstein A, Funke H, Schulte M; et al. (1992). "Nonsynonymous polymorphic sites in the apolipoprotein (apo) A-IV gene are associated with changes in the concentration of apo B- and apo A-I-containing lipoproteins in a normal population". Am. J. Hum. Genet. 50 (5): 1115–28. PMID 1349197.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kamboh MI, Williams ER, Law JC; et al. (1993). "Molecular basis of a unique African variant (A-IV 5) of human apolipoprotein A-IV and its significance in lipid metabolism". Genet. Epidemiol. 9 (6): 379–88. doi:10.1002/gepi.1370090602. PMID 1487136.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lohse P, Kindt MR, Rader DJ, Brewer HB (1991). "Three genetic variants of human plasma apolipoprotein A-IV. apoA-IV-1(Thr347----Ser), apoA-IV-0(Lys167----Glu,Gln360----His), and apoA-IV-3(Glu165----Lys)". J. Biol. Chem. 266 (21): 13513–8. PMID 1677358.CS1 maint: Multiple names: authors list (link)
• Tenkanen H, Koskinen P, Metso J; et al. (1992). "A novel polymorphism of apolipoprotein A-IV is the result of an asparagine to serine substitution at residue 127". Biochim. Biophys. Acta. 1138 (1): 27–33. PMID 1737067.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lohse P, Kindt MR, Rader DJ, Brewer HB (1990). "Human plasma apolipoproteins A-IV-0 and A-IV-3. Molecular basis for two rare variants of apolipoprotein A-IV-1". J. Biol. Chem. 265 (21): 12734–9. PMID 1973689.CS1 maint: Multiple names: authors list (link)
• Tenkanen H, Lukka M, Jauhiainen M; et al. (1991). "The mutation causing the common apolipoprotein A-IV polymorphism is a glutamine to histidine substitution of amino acid 360". Arterioscler. Thromb. 11 (4): 851–6. PMID 2065039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• de Temmerman P, Visvikis S, Boerwinkle E, Siest G (1990). "Study of the sequence tagged site (STS) in the beginning of human apo A4 gene region". Nucleic Acids Res. 18 (18): 5576. PMID 2216752.CS1 maint: Multiple names: authors list (link)
• Wei S, Rocchi M, Archidiacono N; et al. (1990). "Physical mapping of the human chromosome 11q23 region containing the ataxia-telangiectasia locus". Cancer Genet. Cytogenet. 46 (1): 1–8. PMID 2331673.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lohse P, Kindt MR, Rader DJ, Brewer HB (1990). "Genetic polymorphism of human plasma apolipoprotein A-IV is due to nucleotide substitutions in the apolipoprotein A-IV gene". J. Biol. Chem. 265 (17): 10061–4. PMID 2351649.CS1 maint: Multiple names: authors list (link)
• Yang CY, Gu ZW, Chong IS; et al. (1989). "The primary structure of human apolipoprotein A-IV". Biochim. Biophys. Acta. 1002 (2): 231–7. PMID 2930771.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Elshourbagy NA, Walker DW, Paik YK; et al. (1987). "Structure and expression of the human apolipoprotein A-IV gene". J. Biol. Chem. 262 (17): 7973–81. PMID 3036793.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Elshourbagy NA, Walker DW, Boguski MS; et al. (1986). "The nucleotide and derived amino acid sequence of human apolipoprotein A-IV mRNA and the close linkage of its gene to the genes of apolipoproteins A-I and C-III". J. Biol. Chem. 261 (5): 1998–2002. PMID 3080432.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Karathanasis SK, Oettgen P, Haddad IA, Antonarakis SE (1986). "Structure, evolution, and polymorphisms of the human apolipoprotein A4 gene (APOA4)". Proc. Natl. Acad. Sci. U.S.A. 83 (22): 8457–61. PMID 3095836.CS1 maint: Multiple names: authors list (link)
• Bisgaier CL, Sachdev OP, Lee ES; et al. (1987). "Effect of lecithin:cholesterol acyltransferase on distribution of apolipoprotein A-IV among lipoproteins of human plasma". J. Lipid Res. 28 (6): 693–703. PMID 3611972.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Karathanasis SK, Yunis I, Zannis VI (1986). "Structure, evolution, and tissue-specific synthesis of human apolipoprotein AIV". Biochemistry. 25 (13): 3962–70. PMID 3755616.CS1 maint: Multiple names: authors list (link)
• Karathanasis SK (1985). "Apolipoprotein multigene family: tandem organization of human apolipoprotein AI, CIII, and AIV genes". Proc. Natl. Acad. Sci. U.S.A. 82 (19): 6374–8. PMID 3931073.
• Gordon JI, Bisgaier CL, Sims HF; et al. (1984). "Biosynthesis of human preapolipoprotein A-IV". J. Biol. Chem. 259 (1): 468–74. PMID 6706947.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Menzel HJ, Dieplinger H, Sandholzer C; et al. (1995). "Apolipoprotein A-IV polymorphism in the Hungarian population: gene frequencies, effect on lipid levels, and sequence of two new variants". Hum. Mutat. 5 (1): 58–65. doi:10.1002/humu.1380050108. PMID 7728150.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Duverger N, Tremp G, Caillaud JM; et al. (1996). "Protection against atherogenesis in mice mediated by human apolipoprotein A-IV". Science. 273 (5277): 966–8. PMID 8688083.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Deeb SS, Nevin DN, Iwasaki L, Brunzell JD (1997). "Two novel apolipoprotein A-IV variants in individuals with familial combined hyperlipidemia and diminished levels of lipoprotein lipase activity". Hum. Mutat. 8 (4): 319–25. doi:10.1002/(SICI)1098-1004(1996)8:4<319::AID-HUMU4>3.0.CO;2-2. PMID 8956036.CS1 maint: Multiple names: authors list (link)