ALOX12B
| Arachidonate 12-lipoxygenase, 12R type | |||||||||
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| Identifiers | |||||||||
| Symbols | ALOX12B ; 12R-LOX | ||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 884 | ||||||||
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| Orthologs | |||||||||
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| Species | Human | Mouse | |||||||
| Entrez | n/a | n/a | |||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||
| RefSeq (protein) | n/a | n/a | |||||||
| Location (UCSC) | n/a | n/a | |||||||
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Arachidonate 12-lipoxygenase, 12R type, also known as ALOX12B, is a human gene.[1]
This gene encodes an enzyme involved in the conversion of arachidonic acid to 12R-hydroxyeicosatetraenoic acid. Mutations in this gene are associated with nonbullous congenital ichthyosiform erythroderma.[1]
References
Further reading
- Yu Z, Schneider C, Boeglin WE, Brash AR (2007). "Epidermal lipoxygenase products of the hepoxilin pathway selectively activate the nuclear receptor PPARalpha". Lipids. 42 (6): 491–7. doi:10.1007/s11745-007-3054-4. PMID 17436029.
- Lesueur F, Bouadjar B, Lefèvre C; et al. (2007). "Novel mutations in ALOX12B in patients with autosomal recessive congenital ichthyosis and evidence for genetic heterogeneity on chromosome 17p13". J. Invest. Dermatol. 127 (4): 829–34. doi:10.1038/sj.jid.5700640. PMID 17139268.
- Yu Z, Schneider C, Boeglin WE, Brash AR (2005). "Mutations associated with a congenital form of ichthyosis (NCIE) inactivate the epidermal lipoxygenases 12R-LOX and eLOX3". Biochim. Biophys. Acta. 1686 3: 238–47. doi:10.1016/j.bbalip.2004.10.007. PMID 15629692.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- McDonnell M, Li H, Funk CD (2003). "Characterization of epidermal 12(S) and 12(R) lipoxygenases". Adv. Exp. Med. Biol. 507: 147–53. PMID 12664578.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Jobard F, Lefèvre C, Karaduman A; et al. (2002). "Lipoxygenase-3 (ALOXE3) and 12(R)-lipoxygenase (ALOX12B) are mutated in non-bullous congenital ichthyosiform erythroderma (NCIE) linked to chromosome 17p13.1". Hum. Mol. Genet. 11 (1): 107–13. PMID 11773004.
- Schneider C, Keeney DS, Boeglin WE, Brash AR (2001). "Detection and cellular localization of 12R-lipoxygenase in human tonsils". Arch. Biochem. Biophys. 386 (2): 268–74. doi:10.1006/abbi.2000.2217. PMID 11368351.
- Krieg P, Marks F, Fürstenberger G (2001). "A gene cluster encoding human epidermis-type lipoxygenases at chromosome 17p13.1: cloning, physical mapping, and expression". Genomics. 73 (3): 323–30. doi:10.1006/geno.2001.6519. PMID 11350124.
- Tang K, Finley RL, Nie D, Honn KV (2000). "Identification of 12-lipoxygenase interaction with cellular proteins by yeast two-hybrid screening". Biochemistry. 39 (12): 3185–91. PMID 10727209.
- Sun D, McDonnell M, Chen XS; et al. (1999). "Human 12(R)-lipoxygenase and the mouse ortholog. Molecular cloning, expression, and gene chromosomal assignment". J. Biol. Chem. 273 (50): 33540–7. PMID 9837935.
- Boeglin WE, Kim RB, Brash AR (1998). "A 12R-lipoxygenase in human skin: mechanistic evidence, molecular cloning, and expression". Proc. Natl. Acad. Sci. U.S.A. 95 (12): 6744–9. PMID 9618483.
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