WBR0141
| Author | [[PageAuthor::Rim Halaby, M.D. [1]]] |
|---|---|
| Exam Type | ExamType:: |
| Main Category | |
| Sub Category | |
| Prompt | [[Prompt::Neutrophils are critically involved in the inflammation process. The process of leukocyte movement from the blood to the tissues through the blood vessels is known as extravasation, and can be divided up into a number of broad steps. Which of the signaling mediators is involved in the migration of the neutrophils across the endothelial cells?]] |
| Answer A | AnswerA::E selectin and P selectin |
| Answer A Explanation | [[AnswerAExp::E selectin and P selectin are involved in the rolling phase.]] |
| Answer B | AnswerB::ICAM 1 |
| Answer B Explanation | [[AnswerBExp::ICAM 1 is involved in the tight binding of neutrophils to the endothelium.]] |
| Answer C | AnswerC::PECAM 1 |
| Answer C Explanation | [[AnswerCExp::PECAM 1 is involved in diapedesis, which is the migration of the leukocytes across the endothelial cells.]] |
| Answer D | AnswerD::C5a |
| Answer D Explanation | [[AnswerDExp::C5 a is involved in the migration of leykocytes through the interstitum towards the site of inflammation.]] |
| Answer E | AnswerE::Interleukin 8 |
| Answer E Explanation | [[AnswerEExp::Interleukin 8 is involved in the migration of leukocytes through the interstitium towards the site of inflammation.]] |
| Right Answer | RightAnswer::C |
| Explanation | [[Explanation::Education objective: Inflammation involves several steps including the rolling phase of the neutrophils, their binding to the endothelium, diapedesis and migration to the site of inflammation. PECAM 1 is involved in diapedesis, which is the migration of the leukocytes across the endothelial cells. Educational Objective: |
| Approved | Approved::No |
| Keyword | |
| Linked Question | Linked:: |
| Order in Linked Questions | LinkedOrder:: |