Antihypertensive and lipid-lowering treatment to prevent heart attack trial

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) trial compared major outcomes in high risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic.

Design

Randomized, double-blind, multi-center clinical trial

Interventions

Control arm:

• Chlorthalidone

Comparators:

• Calcium channel blocker
• ACE inhibitors
• Alpha blocker

Endpoint

Determine whether occurrence of fatal CHD or nonfatal MI is lower for high-risk hypertensive patients treated with newer agents (CCB, ACEI, alpha-blocker) compared with a diuretic

Population

42,418 high-risk hypertensive patients ≥ 55 years

Results

The alpha blocker arm (doxazosin) was dropped early due to futility.