Coronary heart disease secondary prevention
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Patients who should be treated with secondary prevention are those with established atherosclerosis including peripheral artery disease; carotid artery disease; atherosclerotic aortic disease; diabetes and those with a Framingham Risk Score of > 20%. There are 10 aspects of secondary prevention: Smoking cessation; blood pressure control; lipid-lowering; increasing physical activity; weight loss; diabetes control; antiplatelet agents/anticoagulants; RAS blockers; beta-blockers and influenza vaccine.
Target Population
Patients who should be treated with secondary prevention are those with established atherosclerosis including peripheral artery disease; carotid artery disease; atherosclerotic aortic disease; diabetes and those with a Framingham Risk Score of > 20%.
Smoking Cessation
AHA/ACC Secondary Prevention for Patients With Coronary and Other Vascular Disease : 2006 Update
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Goal: Complete Cessation. No Exposure to environmental tobacco smoke. Class I1. Ask about tobacco use status at every visit. (Level of Evidence: B) 2. Advise every tobacco user to quit. (Level of Evidence: B) 3. Assess the tobacco user's willingness to quit. Level of Evidence: B) 4. Assist counseling and developing a plan for quitting. Level of Evidence: B) 5. Arrange follow-up, referral to special programs, or pharmacotherapy (including nicotine replacement and bupropion). Level of Evidence: B) 6. Urge avoidance of exposure to environmental tobacco smoke at work and home. Level of Evidence: B)
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Blood Pressure Control
- If blood pressure is > 120/80 mm Hg:
Initiate or maintain lifestyle modification (weight control, EtOH moderation, sodium reduction, increased physical activity, increased fruits, vegetables, low-fat dairy)
- If blood pressure > 140/90 mm Hg: As tolerated, add blood pressure medication (betablockers and/or ACE inhibitors initially).
AHA/ACC Secondary Prevention for Patients With Coronary and Other Vascular Disease : 2006 Update
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Goal: <140/90 mm Hg or <130/80 mm Hg if patient has diabetes or chronic kidney disease. For all Patients: Class I1. Initiate or maintain lifestyle modification—weight control; increased physical activity; alcohol moderation; sodium reduction; and emphasis on increased consumption of fresh fruits, vegetables, and low-fat dairy products. (Level of Evidence: B)
Class I1. As tolerated, add blood pressure medication, treating initially with β-blockers and/or ACE inhibitors, with addition of other drugs such as thiazides as needed to achieve goal blood pressure. Level of Evidence: A)
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Lipid Management
AHA/ACC Secondary Prevention for Patients With Coronary and Other Vascular Disease : 2006 Update
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Goal: LDL-C <100 mg/dL; If triglycerides are ≥200 mg/dL, non-HDL-C should be <130 mg/dL.
For all patients:
Physical Activity Recommendations
- Encourage 30 to 60 minutes of moderate intensity aerobic activity such as brisk walking, on most, preferably all, days of the week.
- Advise medically supervised programs for high-risk patients (e.g. recent acute coronary syndrome or revascularization, heart failure)
Weight Management
- Goal: BMI 18.5 to 24.9 kg/m2
- Waist Circumference:
- Men: < 40 inches
- Women: < 35 inches
- If waist circumference >35 inches in women and >40 inches in men initiate lifestyle changes and consider treatment strategies for metabolic syndrome as indicated.
- The initial goal of weight loss therapy should be to reduce body weight by approximately 5-10 percent from baseline.
ACE Inhibition
- Use in all patients with LVEF < 40%, and those with diabetes or chronic kidney disease indefinitely, unless contraindicated
- Consider for all other patients
Angiotensin Receptor Blockade
- Use in patients who are intolerant of ACE inhibitors with heart failure or post MI with LVEF less than or equal to 40%.
- Consider in other patients who are ACE inhibitor intolerant.
Diabetes Mellitus
- Lifestyle and pharmacotherapy to achieve HbA1C <7% may be considered.
- Less stringent goal for may be considered (severe hypoglycemia, limited life expectancy, extensive comorbidities)
Anti-platelet therapy
A meta-analysis of randomized controlled trials by the international Cochrane Collaboration found "that the use of clopidogrel plus aspirin is associated with a reduction in the risk of cardiovascular events compared with aspirin alone in patients with acute non-ST coronary syndrome. In patients at high risk of cardiovascular disease but not presenting acutely, there is only weak evidence of benefit and hazards of treatment almost match any benefit obtained.".[1]
References
- ↑ Keller T, Squizzato A, Middeldorp S (2007). "Clopidogrel plus aspirin versus aspirin alone for preventing cardiovascular disease". Cochrane database of systematic reviews (Online) (3): CD005158. doi:10.1002/14651858.CD005158.pub2. PMID 17636787.