Long QT Syndrome risk stratification
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Long QT Syndrome Microchapters |
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Long QT Syndrome risk stratification On the Web |
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American Roentgen Ray Society Images of Long QT Syndrome risk stratification |
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Risk calculators and risk factors for Long QT Syndrome risk stratification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]
Overview
The genetic variant (LQT1-8), the gender and the QT interval are associated with the risk of a cardiac event. A history of prior events (syncope, fainting spells, seizures, sudden death) and a family history of cardiac events are associated with an increased risk of subsequent cardiac events.
Risk Factors for Torsade de Pointes and Sudden Cardiac Death
- Persons with a history of repeated fainting, accidents, seizures or a history of cardiac arrest.
- Family members of persons with repeated fainting, accidents, seizures or a history of cardiac arrest.
- Persons who are on certain medications that are known to cause a prolonged QT interval on electrocardiogram.
- Persons who are first degree relatives of people with know long QT syndrome.
- Persons who suffer from anorexia nervosa, or who have low levels of magnesium, calcium or potassium in their blood
Risk stratification
The risk for an untreated LQTS patients sustaining an events (syncope or cardiac arrest) can be predicted from their genotype (LQT1-8), gender and corrected QT interval.[1]
High risk
- Risk of event: >50%
QTc > 500 msec LQT1 & LQT2 & LQT3(males)
Intermediate risk
- Risk of event: 30-50%
QTc > 500 msec LQT3(females)
QTc < 500 msec LQT2(females)& LQT3
Low risk
- Risk of event: <30%)
QTc < 500 msec LQT1 & LQT2 (males)
References
- ↑ Risk Stratification in the Long-QT Syndrome: N Engl J Med 2003; 349:908-909, Aug 28, 2003. PMID 12944579.