USP11

Ubiquitin specific peptidase 11
Identifiers
Symbols	USP11 ; UHX1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 31252
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Ubiquitin specific peptidase 11, also known as USP11, is a human gene.

Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This gene encodes a deubiquitinating enzyme which lies in a gene cluster on chromosome Xp11.23

Further reading

• D'Andrea A, Pellman D (1999). "Deubiquitinating enzymes: a new class of biological regulators". Crit. Rev. Biochem. Mol. Biol. 33 (5): 337–52. PMID 9827704.
• Puente XS, Sánchez LM, Overall CM, López-Otín C (2003). "Human and mouse proteases: a comparative genomic approach". Nat. Rev. Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346.CS1 maint: Multiple names: authors list (link)
• Swanson DA, Freund CL, Ploder L; et al. (1996). "A ubiquitin C-terminal hydrolase gene on the proximal short arm of the X chromosome: implications for X-linked retinal disorders". Hum. Mol. Genet. 5 (4): 533–8. PMID 8845848.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brandau O, Nyakatura G, Jedele KB; et al. (1999). "UHX1 and PCTK1: precise characterisation and localisation within a gene-rich region in Xp11.23 and evaluation as candidate genes for retinal diseases mapped to Xp21.1-p11.2". Eur. J. Hum. Genet. 6 (5): 459–66. doi:10.1038/sj.ejhg.5200207. PMID 9801870.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stoddart KL, Jermak C, Nagaraja R; et al. (1999). "Physical map covering a 2 Mb region in human xp11.3 distal to DX6849". Gene. 227 (1): 111–6. PMID 9931462.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Thiselton DL, McDowall J, Brandau O; et al. (2002). "An integrated, functionally annotated gene map of the DXS8026-ELK1 interval on human Xp11.3-Xp11.23: potential hotspot for neurogenetic disorders". Genomics. 79 (4): 560–72. doi:10.1006/geno.2002.6733. PMID 11944989.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ideguchi H, Ueda A, Tanaka M; et al. (2003). "Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM". Biochem. J. 367 (Pt 1): 87–95. doi:10.1042/BJ20011851. PMID 12084015.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Angelats C, Wang XW, Jermiin LS; et al. (2003). "Isolation and characterization of the mouse ubiquitin-specific protease Usp15". Mamm. Genome. 14 (1): 31–46. doi:10.1007/s00335-002-3035-0. PMID 12532266.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bouwmeester T, Bauch A, Ruffner H; et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schoenfeld AR, Apgar S, Dolios G; et al. (2004). "BRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damage". Mol. Cell. Biol. 24 (17): 7444–55. doi:10.1128/MCB.24.17.7444-7455.2004. PMID 15314155.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ross MT, Grafham DV, Coffey AJ; et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMID 15772651.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)