UCN2

Urocortin 2
Identifiers
Symbols	UCN2 ; URP; SRP; UCN-II; UCNI
External IDs	Template:OMIM5 HomoloGene: 50048
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Urocortin 2, also known as UCN2, is a human gene.

This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II.

Further reading

• Hauger RL, Grigoriadis DE, Dallman MF; et al. (2003). "International Union of Pharmacology. XXXVI. Current status of the nomenclature for receptors for corticotropin-releasing factor and their ligands". Pharmacol. Rev. 55 (1): 21–6. doi:10.1124/pr.55.1.3. PMID 12615952.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Florio P, Torres PB, Torricelli M; et al. (2006). "Human endometrium expresses urocortin II and III messenger RNA and peptides". Fertil. Steril. 86 (6): 1766–70. doi:10.1016/j.fertnstert.2006.05.041. PMID 17074339.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Imperatore A, Florio P, Torres PB; et al. (2006). "Urocortin 2 and urocortin 3 are expressed by the human placenta, deciduas, and fetal membranes". Am. J. Obstet. Gynecol. 195 (1): 288–95. doi:10.1016/j.ajog.2005.12.048. PMID 16626608.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Isfort RJ, Wang F, Tscheiner M; et al. (2006). "Modifications of the human urocortin 2 peptide that improve pharmacological properties". Peptides. 27 (7): 1806–13. doi:10.1016/j.peptides.2006.01.003. PMID 16476507.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Czimmer J, Million M, Taché Y (2006). "Urocortin 2 acts centrally to delay gastric emptying through sympathetic pathways while CRF and urocortin 1 inhibitory actions are vagal dependent in rats". Am. J. Physiol. Gastrointest. Liver Physiol. 290 (3): G511–8. doi:10.1152/ajpgi.00289.2005. PMID 16223946.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chang CL, Hsu SY (2005). "Ancient evolution of stress-regulating peptides in vertebrates". Peptides. 25 (10): 1681–8. doi:10.1016/j.peptides.2004.05.022. PMID 15476935.
• Karteris E, Hillhouse EW, Grammatopoulos D (2004). "Urocortin II is expressed in human pregnant myometrial cells and regulates myosin light chain phosphorylation: potential role of the type-2 corticotropin-releasing hormone receptor in the control of myometrial contractility". Endocrinology. 145 (2): 890–900. doi:10.1210/en.2003-1210. PMID 14592950.CS1 maint: Multiple names: authors list (link)
• Chanalaris A, Lawrence KM, Stephanou A; et al. (2004). "Protective effects of the urocortin homologues stresscopin (SCP) and stresscopin-related peptide (SRP) against hypoxia/reoxygenation injury in rat neonatal cardiomyocytes". J. Mol. Cell. Cardiol. 35 (10): 1295–305. PMID 14519439.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lewis K, Li C, Perrin MH; et al. (2001). "Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7570–5. doi:10.1073/pnas.121165198. PMID 11416224.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hsu SY, Hsueh AJ (2001). "Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor". Nat. Med. 7 (5): 605–11. doi:10.1038/87936. PMID 11329063.
• Reyes TM, Lewis K, Perrin MH; et al. (2001). "Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors". Proc. Natl. Acad. Sci. U.S.A. 98 (5): 2843–8. doi:10.1073/pnas.051626398. PMID 11226328.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)