TNKS

Tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
Identifiers
Symbols	TNKS ; PARPL; PARP-5a; PARP5A; TIN1; TINF1; TNKS1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 18405
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE TNKS 202561 at tn.png
File:PBB GE TNKS 216695 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase, also known as TNKS, is a human gene.

Further reading

• Andersson B, Wentland MA, Ricafrente JY; et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yu W, Andersson B, Worley KC; et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. PMID 9110174.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Smith S, Giriat I, Schmitt A, de Lange T (1998). "Tankyrase, a poly(ADP-ribose) polymerase at human telomeres". Science. 282 (5393): 1484–7. PMID 9822378.CS1 maint: Multiple names: authors list (link)
• Zhu L, Smith S, de Lange T, Seldin MF (1999). "Chromosomal mapping of the tankyrase gene in human and mouse". Genomics. 57 (2): 320–1. doi:10.1006/geno.1999.5771. PMID 10198177.CS1 maint: Multiple names: authors list (link)
• Smith S, de Lange T (1999). "Cell cycle dependent localization of the telomeric PARP, tankyrase, to nuclear pore complexes and centrosomes". J. Cell. Sci. 112 ( Pt 21): 3649–56. PMID 10523501.
• Chi NW, Lodish HF (2001). "Tankyrase is a golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles". J. Biol. Chem. 275 (49): 38437–44. doi:10.1074/jbc.M007635200. PMID 10988299.
• Lyons RJ, Deane R, Lynch DK; et al. (2001). "Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14". J. Biol. Chem. 276 (20): 17172–80. doi:10.1074/jbc.M009756200. PMID 11278563.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kim BY, Krämer H, Yamamoto A; et al. (2001). "Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7". J. Biol. Chem. 276 (31): 29393–402. doi:10.1074/jbc.M101778200. PMID 11382755.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cook BD, Dynek JN, Chang W; et al. (2002). "Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres". Mol. Cell. Biol. 22 (1): 332–42. PMID 11739745.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sbodio JI, Lodish HF, Chi NW (2002). "Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase)". Biochem. J. 361 (Pt 3): 451–9. PMID 11802774.CS1 maint: Multiple names: authors list (link)
• Seimiya H, Smith S (2002). "The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182)". J. Biol. Chem. 277 (16): 14116–26. doi:10.1074/jbc.M112266200. PMID 11854288.
• Sbodio JI, Chi NW (2002). "Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner". J. Biol. Chem. 277 (35): 31887–92. doi:10.1074/jbc.M203916200. PMID 12080061.
• Rippmann JF, Damm K, Schnapp A (2002). "Functional characterization of the poly(ADP-ribose) polymerase activity of tankyrase 1, a potential regulator of telomere length". J. Mol. Biol. 323 (2): 217–24. PMID 12381316.CS1 maint: Multiple names: authors list (link)
• Bae J, Donigian JR, Hsueh AJ (2003). "Tankyrase 1 interacts with Mcl-1 proteins and inhibits their regulation of apoptosis". J. Biol. Chem. 278 (7): 5195–204. doi:10.1074/jbc.M201988200. PMID 12475993.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Loayza D, De Lange T (2003). "POT1 as a terminal transducer of TRF1 telomere length control". Nature. 423 (6943): 1013–8. doi:10.1038/nature01688. PMID 12768206.
• Fuchs U, Rehkamp GF, Slany R; et al. (2003). "The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance". FEBS Lett. 554 (1–2): 10–6. PMID 14596906.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Seimiya H, Muramatsu Y, Smith S, Tsuruo T (2004). "Functional subdomain in the ankyrin domain of tankyrase 1 required for poly(ADP-ribosyl)ation of TRF1 and telomere elongation". Mol. Cell. Biol. 24 (5): 1944–55. PMID 14966275.CS1 maint: Multiple names: authors list (link)
• Dynek JN, Smith S (2004). "Resolution of sister telomere association is required for progression through mitosis". Science. 304 (5667): 97–100. doi:10.1126/science.1094754. PMID 15064417.
• Ye JZ, de Lange T (2004). "TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex". Nat. Genet. 36 (6): 618–23. doi:10.1038/ng1360. PMID 15133513.