Small nuclear ribonucleoprotein D2

Small nuclear ribonucleoprotein D2 polypeptide 16.5kDa
File:PBB Protein SNRPD2 image.jpg PDB rendering based on 1b34.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1b34​
Identifiers
Symbols	SNRPD2 ; SNRPD1; SMD2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3381
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Small nuclear ribonucleoprotein D2 polypeptide 16.5kDa, also known as SNRPD2, is a human gene.

The protein encoded by this gene belongs to the small nuclear ribonucleoprotein core protein family. It is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.

Further reading

• Lehmeier T, Foulaki K, Lührmann R (1991). "Evidence for three distinct D proteins, which react differentially with anti-Sm autoantibodies, in the cores of the major snRNPs U1, U2, U4/U6 and U5". Nucleic Acids Res. 18 (22): 6475–84. PMID 1701240.CS1 maint: Multiple names: authors list (link)
• Rokeach LA, Haselby JA, Hoch SO (1988). "Molecular cloning of a cDNA encoding the human Sm-D autoantigen". Proc. Natl. Acad. Sci. U.S.A. 85 (13): 4832–6. PMID 3260384.CS1 maint: Multiple names: authors list (link)
• Lehmeier T, Raker V, Hermann H, Lührmann R (1995). "cDNA cloning of the Sm proteins D2 and D3 from human small nuclear ribonucleoproteins: evidence for a direct D1-D2 interaction". Proc. Natl. Acad. Sci. U.S.A. 91 (25): 12317–21. PMID 7527560.CS1 maint: Multiple names: authors list (link)
• Liu Q, Fischer U, Wang F, Dreyfuss G (1997). "The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins". Cell. 90 (6): 1013–21. PMID 9323129.CS1 maint: Multiple names: authors list (link)
• Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (1998). "Multiple protein: protein interactions between the snRNP common core proteins". Exp. Cell Res. 237 (1): 63–9. doi:10.1006/excr.1997.3750. PMID 9417867.CS1 maint: Multiple names: authors list (link)
• Kambach C, Walke S, Young R; et al. (1999). "Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs". Cell. 96 (3): 375–87. PMID 10025403.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Charroux B, Pellizzoni L, Perkinson RA; et al. (2000). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems". J. Cell Biol. 147 (6): 1181–94. PMID 10601333.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Charroux B, Pellizzoni L, Perkinson RA; et al. (2000). "Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli". J. Cell Biol. 148 (6): 1177–86. PMID 10725331.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Meister G, Bühler D, Laggerbauer B; et al. (2000). "Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins". Hum. Mol. Genet. 9 (13): 1977–86. PMID 10942426.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ajuh P, Kuster B, Panov K; et al. (2001). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMID 11101529.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Selenko P, Sprangers R, Stier G; et al. (2001). "SMN tudor domain structure and its interaction with the Sm proteins". Nat. Struct. Biol. 8 (1): 27–31. doi:10.1038/83014. PMID 11135666.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Urlaub H, Raker VA, Kostka S, Lührmann R (2001). "Sm protein-Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure". EMBO J. 20 (1–2): 187–96. doi:10.1093/emboj/20.1.187. PMID 11226169.CS1 maint: Multiple names: authors list (link)
• Gubitz AK, Mourelatos Z, Abel L; et al. (2002). "Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins". J. Biol. Chem. 277 (7): 5631–6. doi:10.1074/jbc.M109448200. PMID 11714716.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pellizzoni L, Baccon J, Rappsilber J; et al. (2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component". J. Biol. Chem. 277 (9): 7540–5. doi:10.1074/jbc.M110141200. PMID 11748230.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Friesen WJ, Wyce A, Paushkin S; et al. (2002). "A novel WD repeat protein component of the methylosome binds Sm proteins". J. Biol. Chem. 277 (10): 8243–7. doi:10.1074/jbc.M109984200. PMID 11756452.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fong YW, Zhou Q (2002). "Stimulatory effect of splicing factors on transcriptional elongation". Nature. 414 (6866): 929–33. doi:10.1038/414929a. PMID 11780068.
• Jurica MS, Licklider LJ, Gygi SR; et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. PMID 11991638.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Baccon J, Pellizzoni L, Rappsilber J; et al. (2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex". J. Biol. Chem. 277 (35): 31957–62. doi:10.1074/jbc.M203478200. PMID 12065586.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Blagoev B, Kratchmarova I, Ong SE; et al. (2003). "A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling". Nat. Biotechnol. 21 (3): 315–8. doi:10.1038/nbt790. PMID 12577067.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)