STXBP1

Syntaxin binding protein 1
File:PBB Protein STXBP1 image.jpg PDB rendering based on 1dn1.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1dn1​
Identifiers
Symbols	STXBP1 ; MUNC18-1; UNC18; hUNC18; rbSec1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2382
Gene ontology Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE STXBP1 202260 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Syntaxin binding protein 1, also known as STXBP1, is a human gene.

Further reading

• Garcia EP, McPherson PS, Chilcote TJ; et al. (1995). "rbSec1A and B colocalize with syntaxin 1 and SNAP-25 throughout the axon, but are not in a stable complex with syntaxin". J. Cell Biol. 129 (1): 105–20. PMID 7698978.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pevsner J, Hsu SC, Scheller RH (1994). "n-Sec1: a neural-specific syntaxin-binding protein". Proc. Natl. Acad. Sci. U.S.A. 91 (4): 1445–9. PMID 8108429.CS1 maint: Multiple names: authors list (link)
• Fujita Y, Sasaki T, Fukui K; et al. (1996). "Phosphorylation of Munc-18/n-Sec1/rbSec1 by protein kinase C: its implication in regulating the interaction of Munc-18/n-Sec1/rbSec1 with syntaxin". J. Biol. Chem. 271 (13): 7265–8. PMID 8631738.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gengyo-Ando K, Kitayama H, Mukaida M, Ikawa Y (1996). "A murine neural-specific homolog corrects cholinergic defects in Caenorhabditis elegans unc-18 mutants". J. Neurosci. 16 (21): 6695–702. PMID 8824310.CS1 maint: Multiple names: authors list (link)
• Tellam JT, Macaulay SL, McIntosh S; et al. (1997). "Characterization of Munc-18c and syntaxin-4 in 3T3-L1 adipocytes. Putative role in insulin-dependent movement of GLUT-4". J. Biol. Chem. 272 (10): 6179–86. PMID 9045631.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Verhage M, de Vries KJ, Røshol H; et al. (1997). "DOC2 proteins in rat brain: complementary distribution and proposed function as vesicular adapter proteins in early stages of secretion". Neuron. 18 (3): 453–61. PMID 9115738.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Okamoto M, Südhof TC (1998). "Mints, Munc18-interacting proteins in synaptic vesicle exocytosis". J. Biol. Chem. 272 (50): 31459–64. PMID 9395480.
• Swanson DA, Steel JM, Valle D (1998). "Identification and characterization of the human ortholog of rat STXBP1, a protein implicated in vesicle trafficking and neurotransmitter release". Genomics. 48 (3): 373–6. doi:10.1006/geno.1997.5202. PMID 9545644.CS1 maint: Multiple names: authors list (link)
• Fletcher AI, Shuang R, Giovannucci DR; et al. (1999). "Regulation of exocytosis by cyclin-dependent kinase 5 via phosphorylation of Munc18". J. Biol. Chem. 274 (7): 4027–35. PMID 9933594.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Reed GL, Houng AK, Fitzgerald ML (1999). "Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion". Blood. 93 (8): 2617–26. PMID 10194441.CS1 maint: Multiple names: authors list (link)
• Dulubova I, Sugita S, Hill S; et al. (1999). "A conformational switch in syntaxin during exocytosis: role of munc18". EMBO J. 18 (16): 4372–82. doi:10.1093/emboj/18.16.4372. PMID 10449403.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Misura KM, Scheller RH, Weis WI (2000). "Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex". Nature. 404 (6776): 355–62. doi:10.1038/35006120. PMID 10746715.CS1 maint: Multiple names: authors list (link)
• Allan BB, Moyer BD, Balch WE (2000). "Rab1 recruitment of p115 into a cis-SNARE complex: programming budding COPII vesicles for fusion". Science. 289 (5478): 444–8. PMID 10903204.CS1 maint: Multiple names: authors list (link)
• Shorter J, Beard MB, Seemann J; et al. (2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115". J. Cell Biol. 157 (1): 45–62. doi:10.1083/jcb.200112127. PMID 11927603.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ho CS, Marinescu V, Steinhilb ML; et al. (2002). "Synergistic effects of Munc18a and X11 proteins on amyloid precursor protein metabolism". J. Biol. Chem. 277 (30): 27021–8. doi:10.1074/jbc.M201823200. PMID 12016213.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pérez-Brangulí F, Muhaisen A, Blasi J (2002). "Munc 18a binding to syntaxin 1A and 1B isoforms defines its localization at the plasma membrane and blocks SNARE assembly in a three-hybrid system assay". Mol. Cell. Neurosci. 20 (2): 169–80. PMID 12093152.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Barclay JW, Craig TJ, Fisher RJ; et al. (2003). "Phosphorylation of Munc18 by protein kinase C regulates the kinetics of exocytosis". J. Biol. Chem. 278 (12): 10538–45. doi:10.1074/jbc.M211114200. PMID 12519779.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fukuda M (2003). "Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells". J. Biol. Chem. 278 (17): 15390–6. doi:10.1074/jbc.M213090200. PMID 12590134.
• Craig TJ, Evans GJ, Morgan A (2003). "Physiological regulation of Munc18/nSec1 phosphorylation on serine-313". J. Neurochem. 86 (6): 1450–7. PMID 12950453.CS1 maint: Multiple names: authors list (link)