SOCS5
| Suppressor of cytokine signaling 5 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | SOCS5 ; CIS6; CISH6; Cish5; KIAA0671; SOCS-5 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 10495 | ||||||||||
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| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Suppressor of cytokine signaling 5, also known as SOCS5, is a human gene.[1]
The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported.[1]
References
Further reading
- Kile BT, Schulman BA, Alexander WS; et al. (2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem. Sci. 27 (5): 235–41. PMID 12076535.
- Wang J, Campbell IL (2002). "Cytokine signaling in the brain: putting a SOCS in it?". J. Neurosci. Res. 67 (4): 423–7. PMID 11835308.
- Krebs DL, Hilton DJ (2001). "SOCS proteins: negative regulators of cytokine signaling". Stem Cells. 19 (5): 378–87. PMID 11553846.
- Ozaki A, Seki Y, Fukushima A, Kubo M (2005). "The control of allergic conjunctivitis by suppressor of cytokine signaling (SOCS)3 and SOCS5 in a murine model". J. Immunol. 175 (8): 5489–97. PMID 16210657.
- Kario E, Marmor MD, Adamsky K; et al. (2005). "Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling". J. Biol. Chem. 280 (8): 7038–48. doi:10.1074/jbc.M408575200. PMID 15590694.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Bayle J, Letard S, Frank R; et al. (2004). "Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling". J. Biol. Chem. 279 (13): 12249–59. doi:10.1074/jbc.M313381200. PMID 14707129.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Seki Y, Hayashi K, Matsumoto A; et al. (2002). "Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation". Proc. Natl. Acad. Sci. U.S.A. 99 (20): 13003–8. doi:10.1073/pnas.202477099. PMID 12242343.
- Wiemann S, Weil B, Wellenreuther R; et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
- Magrangeas F, Apiou F, Denis S; et al. (2000). "Cloning and expression of CIS6, chromosome assignment to 3p22 and 2p21 by in situ hybridization". Cytogenet. Cell Genet. 88 (1–2): 78–81. PMID 10773671.
- Ishikawa K, Nagase T, Suyama M; et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. PMID 9734811.
- Hilton DJ, Richardson RT, Alexander WS; et al. (1998). "Twenty proteins containing a C-terminal SOCS box form five structural classes". Proc. Natl. Acad. Sci. U.S.A. 95 (1): 114–9. PMID 9419338.
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