SOCS2

Suppressor of cytokine signaling 2
File:PBB Protein SOCS2 image.jpg PDB rendering based on 2c9w.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2c9w​
Identifiers
Symbols	SOCS2 ; CIS2; Cish2; SOCS-2; SSI-2; SSI2; STATI2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2880
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SOCS2 203373 at tn.png
File:PBB GE SOCS2 203372 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Suppressor of cytokine signaling 2, also known as SOCS2, is a human gene.

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon (IFN)-gamma. The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling. Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control.

Further reading

• Lopaczynski W (1999). "Differential regulation of signaling pathways for insulin and insulin-like growth factor I.". Acta Biochim. Pol. 46 (1): 51–60. PMID 10453981.
• Wang J, Campbell IL (2002). "Cytokine signaling in the brain: putting a SOCS in it?". J. Neurosci. Res. 67 (4): 423–7. PMID 11835308.
• Kile BT, Schulman BA, Alexander WS; et al. (2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem. Sci. 27 (5): 235–41. PMID 12076535.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pezet A, Buteau H, Kelly PA, Edery M (1997). "The last proline of Box 1 is essential for association with JAK2 and functional activation of the prolactin receptor". Mol. Cell. Endocrinol. 129 (2): 199–208. PMID 9202403.CS1 maint: Multiple names: authors list (link)
• Minamoto S, Ikegame K, Ueno K; et al. (1997). "Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3". Biochem. Biophys. Res. Commun. 237 (1): 79–83. doi:10.1006/bbrc.1997.7080. PMID 9266833.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Masuhara M, Sakamoto H, Matsumoto A; et al. (1997). "Cloning and characterization of novel CIS family genes". Biochem. Biophys. Res. Commun. 239 (2): 439–46. doi:10.1006/bbrc.1997.7484. PMID 9344848.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dey BR, Spence SL, Nissley P, Furlanetto RW (1998). "Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor". J. Biol. Chem. 273 (37): 24095–101. PMID 9727029.CS1 maint: Multiple names: authors list (link)
• Pezet A, Favre H, Kelly PA, Edery M (1999). "Inhibition and restoration of prolactin signal transduction by suppressors of cytokine signaling". J. Biol. Chem. 274 (35): 24497–502. PMID 10455112.CS1 maint: Multiple names: authors list (link)
• Yandava CN, Pillari A, Drazen JM (1999). "Radiation hybrid and cytogenetic mapping of SOCS1 and SOCS2 to chromosomes 16p13 and 12q, respectively". Genomics. 61 (1): 108–11. doi:10.1006/geno.1999.5937. PMID 10512686.CS1 maint: Multiple names: authors list (link)
• Ram PA, Waxman DJ (2000). "SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms". J. Biol. Chem. 274 (50): 35553–61. PMID 10585430.
• Metcalf D, Greenhalgh CJ, Viney E; et al. (2000). "Gigantism in mice lacking suppressor of cytokine signalling-2". Nature. 405 (6790): 1069–73. doi:10.1038/35016611. PMID 10890450.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shen X, Hong F, Nguyen VA, Gao B (2000). "IL-10 attenuates IFN-alpha-activated STAT1 in the liver: involvement of SOCS2 and SOCS3". FEBS Lett. 480 (2–3): 132–6. PMID 11034314.CS1 maint: Multiple names: authors list (link)
• Eyckerman S, Verhee A, der Heyden JV; et al. (2002). "Design and application of a cytokine-receptor-based interaction trap". Nat. Cell Biol. 3 (12): 1114–9. doi:10.1038/ncb1201-1114. PMID 11781573.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schultheis B, Carapeti-Marootian M, Hochhaus A; et al. (2002). "Overexpression of SOCS-2 in advanced stages of chronic myeloid leukemia: possible inadequacy of a negative feedback mechanism". Blood. 99 (5): 1766–75. PMID 11861294.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Blumenstein M, Bowen-Shauver JM, Keelan JA, Mitchell MD (2002). "Identification of suppressors of cytokine signaling (SOCS) proteins in human gestational tissues: differential regulation is associated with the onset of labor". J. Clin. Endocrinol. Metab. 87 (3): 1094–7. PMID 11889171.CS1 maint: Multiple names: authors list (link)
• Biener E, Maurice S, Sandowski Y; et al. (2003). "Recombinant human CIS2 (SOCS2) protein: subcloning, expression, purification, and characterization". Protein Expr. Purif. 25 (2): 305–12. PMID 12135564.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)