SLC22A2

Solute carrier family 22 (organic cation transporter), member 2
Identifiers
Symbols	SLC22A2 ; OCT2; MGC32628
External IDs	Template:OMIM5 Template:MGI HomoloGene: 68293
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SLC22A2 207429 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Solute carrier family 22 (organic cation transporter), member 2, also known as SLC22A2, is a human gene.

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption.

See also

• Solute carrier family

Further reading

• Berkhout B, Jeang KT (1992). "Functional roles for the TATA promoter and enhancers in basal and Tat-induced expression of the human immunodeficiency virus type 1 long terminal repeat". J. Virol. 66 (1): 139–49. PMID 1727476.
• Jeang KT, Chun R, Lin NH; et al. (1993). "In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor". J. Virol. 67 (10): 6224–33. PMID 7690421.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu YZ, Lania L, Latchman DS (1997). "Functional interaction between the HIV-1 Tat transactivator and the inhibitory domain of the Oct-2 cellular transcription factor". AIDS. 10 (12): 1323–9. PMID 8902060.CS1 maint: Multiple names: authors list (link)
• Liu YZ, Latchman DS (1997). "The octamer-binding proteins Oct-1 and Oct-2 repress the HIV long terminal repeat promoter and its transactivation by Tat". Biochem. J. 322 ( Pt 1): 155–8. PMID 9078256.
• Gorboulev V, Ulzheimer JC, Akhoundova A; et al. (1997). "Cloning and characterization of two human polyspecific organic cation transporters". DNA Cell Biol. 16 (7): 871–81. PMID 9260930.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Koehler MR, Wissinger B, Gorboulev V; et al. (1998). "The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26". Cytogenet. Cell Genet. 79 (3–4): 198–200. PMID 9605850.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Busch AE, Karbach U, Miska D; et al. (1998). "Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine". Mol. Pharmacol. 54 (2): 342–52. PMID 9687576.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Verhaagh S, Schweifer N, Barlow DP, Zwart R (1999). "Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27". Genomics. 55 (2): 209–18. doi:10.1006/geno.1998.5639. PMID 9933568.CS1 maint: Multiple names: authors list (link)
• Gründemann D, Schömig E (2000). "Gene structures of the human non-neuronal monoamine transporters EMT and OCT2". Hum. Genet. 106 (6): 627–35. PMID 10942111.
• Pietig G, Mehrens T, Hirsch JR; et al. (2001). "Properties and regulation of organic cation transport in freshly isolated human proximal tubules". J. Biol. Chem. 276 (36): 33741–6. doi:10.1074/jbc.M104617200. PMID 11447227.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Boehm J, He Y, Greiner A; et al. (2001). "Regulation of BOB.1/OBF.1 stability by SIAH". EMBO J. 20 (15): 4153–62. doi:10.1093/emboj/20.15.4153. PMID 11483518.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Barendt WM, Wright SH (2002). "The human organic cation transporter (hOCT2) recognizes the degree of substrate ionization". J. Biol. Chem. 277 (25): 22491–6. doi:10.1074/jbc.M203114200. PMID 11953440.
• Urakami Y, Akazawa M, Saito H; et al. (2002). "cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney". J. Am. Soc. Nephrol. 13 (7): 1703–10. PMID 12089365.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Leabman MK, Huang CC, Kawamoto M; et al. (2003). "Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function". Pharmacogenetics. 12 (5): 395–405. PMID 12142729.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cetinkaya I, Ciarimboli G, Yalçinkaya G; et al. (2003). "Regulation of human organic cation transporter hOCT2 by PKA, PI3K, and calmodulin-dependent kinases". Am. J. Physiol. Renal Physiol. 284 (2): F293–302. doi:10.1152/ajprenal.00251.2002. PMID 12388397.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gründemann D, Hahne C, Berkels R, Schömig E (2003). "Agmatine is efficiently transported by non-neuronal monoamine transporters extraneuronal monoamine transporter (EMT) and organic cation transporter 2 (OCT2)". J. Pharmacol. Exp. Ther. 304 (2): 810–7. doi:10.1124/jpet.102.044404. PMID 12538837.CS1 maint: Multiple names: authors list (link)
• Bottalico B, Larsson I, Brodszki J; et al. (2004). "Norepinephrine transporter (NET), serotonin transporter (SERT), vesicular monoamine transporter (VMAT2) and organic cation transporters (OCT1, 2 and EMT) in human placenta from pre-eclamptic and normotensive pregnancies". Placenta. 25 (6): 518–29. doi:10.1016/j.placenta.2003.10.017. PMID 15135235.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lips KS, Volk C, Schmitt BM; et al. (2005). "Polyspecific cation transporters mediate luminal release of acetylcholine from bronchial epithelium". Am. J. Respir. Cell Mol. Biol. 33 (1): 79–88. doi:10.1165/rcmb.2004-0363OC. PMID 15817714.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jiang W, Prokopenko O, Wong L; et al. (2005). "IRIP, a new ischemia/reperfusion-inducible protein that participates in the regulation of transporter activity". Mol. Cell. Biol. 25 (15): 6496–508. doi:10.1128/MCB.25.15.6496-6508.2005. PMID 16024787.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.