SLC22A12

Solute carrier family 22 (organic anion/cation transporter), member 12
Identifiers
Symbols	SLC22A12 ; OAT4L; RST; URAT1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 56442
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Solute carrier family 22 (organic anion/cation transporter), member 12, also known as SLC22A12, is a human gene.

The protein encoded by this gene is a urate transporter and urate-anion exchanger which regulates the level of urate in the blood. This protein is an integral membrane protein primarily found in kidney. Two transcript variants encoding different isoforms have been found for this gene.

See also

• Solute carrier family

Further reading

• Hediger MA, Johnson RJ, Miyazaki H, Endou H (2005). "Molecular physiology of urate transport". Physiology (Bethesda, Md.). 20: 125–33. doi:10.1152/physiol.00039.2004. PMID 15772301.CS1 maint: Multiple names: authors list (link)
• Enomoto A, Kimura H, Chairoungdua A; et al. (2002). "Molecular identification of a renal urate anion exchanger that regulates blood urate levels". Nature. 417 (6887): 447–52. doi:10.1038/nature742. PMID 12024214.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gisler SM, Pribanic S, Bacic D; et al. (2004). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney Int. 64 (5): 1733–45. doi:10.1046/j.1523-1755.2003.00266.x. PMID 14531806.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ichida K, Hosoyamada M, Hisatome I; et al. (2004). "Clinical and molecular analysis of patients with renal hypouricemia in Japan-influence of URAT1 gene on urinary urate excretion". J. Am. Soc. Nephrol. 15 (1): 164–73. PMID 14694169.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Anzai N, Miyazaki H, Noshiro R; et al. (2004). "The multivalent PDZ domain-containing protein PDZK1 regulates transport activity of renal urate-anion exchanger URAT1 via its C terminus". J. Biol. Chem. 279 (44): 45942–50. doi:10.1074/jbc.M406724200. PMID 15304510.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Iwai N, Mino Y, Hosoyamada M; et al. (2004). "A high prevalence of renal hypouricemia caused by inactive SLC22A12 in Japanese". Kidney Int. 66 (3): 935–44. doi:10.1111/j.1523-1755.2004.00839.x. PMID 15327384.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takahashi T, Tsuchida S, Oyamada T; et al. (2005). "Recurrent URAT1 gene mutations and prevalence of renal hypouricemia in Japanese". Pediatr. Nephrol. 20 (5): 576–8. doi:10.1007/s00467-005-1830-z. PMID 15772829.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Taniguchi A, Urano W, Yamanaka M; et al. (2005). "A common mutation in an organic anion transporter gene, SLC22A12, is a suppressing factor for the development of gout". Arthritis Rheum. 52 (8): 2576–7. doi:10.1002/art.21242. PMID 16059895.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shima Y, Teruya K, Ohta H (2006). "Association between intronic SNP in urate-anion exchanger gene, SLC22A12, and serum uric acid levels in Japanese". Life Sci. 79 (23): 2234–7. doi:10.1016/j.lfs.2006.07.030. PMID 16920156.CS1 maint: Multiple names: authors list (link)
• Ohtsuka Y, Zaitsu M, Ichida K; et al. (2007). "Human uric acid transporter 1 gene analysis in familial renal hypo-uricemia associated with exercise-induced acute renal failure". Pediatrics international : official journal of the Japan Pediatric Society. 49 (2): 235–7. doi:10.1111/j.1442-200X.2007.02337.x. PMID 17445045.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.